Journal of Biomolecular Structure and Dynamics,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Фев. 22, 2024
Resistance
to
chemotherapeutics
is
an
eminent
cause
that
leads
search
for
options
help
in
diminution
of
pancreatic
ductal
adenocarcinoma
(PDAC)
by
overcoming
resistance
issues.
Caffeic
acid
(CFA),
a
polyphenol
occurring
many
dietary
foods,
known
show
antidiabetic
and
anticancer
properties
potential.
To
unveil
the
effect
CFA
on
PDAC,
we
carried
out
this
research
PDAC
cells,
following
which
checked
combination
pre-sensitization
effects
CFA.
Multitudinous
web-based
approaches
were
applied
identifying
targets
then
getting
their
interconnections.
Subsequently,
manifested
in-vitro
analysis
showing
IC50
concentrations
37.37
15.06
µM
Panc-1
Mia-PaCa-2,
respectively.
The
index
with
different
drugs
was
explored
showed
antagonistic
treatment
leading
further
investigation
pre-sensitizing
effects.
reduced
concentration
doxorubicin
both
cell
lines
also
triggered
ROS
generation
determined
2′,7′-dichlorofluorescin
diacetate
assay.
differential
gene
expression
after
discrete
genes
affected
i.e.
N-Cad
Cas9
Pi3K/AkT/mTOR
along
p53
Mia-PaCa-2.
Collectively,
study
investigated
role
as
therapeutics
mechanism
mitigating
sensitizing
chemotherapeutics.
Molecules,
Год журнала:
2023,
Номер
28(16), С. 6071 - 6071
Опубликована: Авг. 15, 2023
Yellow
Himalayan
raspberry
(Rubus
ellipticus
Sm.,
Rosaceae)
is
a
native
species
of
the
Indian
subcontinent,
Southern
China,
and
Philippines,
which
has
been
historically
used
as
traditional
medicine
food.
All
parts
this
plant
have
in
to
treat
respiratory
ailments,
diabetes,
gastrointestinal
disorder,
an
anti-infective
agent.
The
scientific
evaluation
revealed
richness
macronutrients,
micronutrients,
minerals
fruits,
indicating
its
potential
use
nutraceutical.
Furthermore,
found
be
rich
various
secondary
metabolites,
including
polyphenols,
flavonoids,
anthocyanins,
tannins,
terpenoids.
Ascorbic
acid,
kaempferol,
gallic
catechin
are
some
compounds
plant,
widely
discussed
for
their
health
benefits.
extracts
obtained
from
R.
shown
antioxidant,
antidiabetic,
anticancer,
anti-inflammatory,
nephroprotective,
antipyretic,
anticonvulsant,
activities
investigated
through
different
study
models.
These
findings
literature
validated
widespread
uses
fruits
folk
medicinal
systems
consumption
nutritious
wild
fruit
by
local
communities.
In
conclusion,
holds
strong
development
It
can
also
improve
nutritional
status
villagers
uplift
economy
if
properly
utilized
marketed.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(16), С. 20551 - 20562
Опубликована: Апрель 13, 2023
Protein-based
coatings
are
of
immense
interest
due
to
their
rich
biological
functions.
Layer-by-layer
(LbL)
assembly,
as
a
powerful
means
transferring
protein
functions
the
material
surface,
has
received
widespread
attention.
However,
assembly
mechanism
protein-based
LbL
is
still
far
from
being
explained,
not
only
because
structure
and
function
diversity
but
also
characterization
limitations.
Herein,
we
monitored
in
situ
process
tannic
acid
(TA)
lysozyme
(Lyz),
classic
pair
polyphenol
protein,
by
combining
quartz
crystal
microbalance
with
dissipation
monitoring
(QCM-D)
spectroscopic
ellipsometry
(SE).
The
water
content,
morphology,
mechanical
properties,
antioxidant
activity,
driving
force
TA-Lyz
coating
engineered
under
different
pH
values
were
analyzed
detail
various
techniques.
key
factor
coatings,
increased
increasing
assembled
values,
which
resulted
porous
inhomogeneous
distribution,
faster
growth,
better
activity
both
acellular
cellular
levels.
In
addition,
high
content
unfavorable
entropy
enthalpy
changes,
thermodynamic
TA
Lyz
mainly
comes
change
brought
noncovalent
interaction
between
Lyz.
These
results
provide
new
insights
into
engineering
structure,
function,
mechanisms
coatings.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(27), С. 9992 - 10008
Опубликована: Июнь 7, 2023
Sinensetin
is
among
the
most
ubiquitous
polyphenols
in
citrus
fruit
and
recently
has
been
extensively
studied
for
its
ability
to
prevent
or
treat
diseases.
The
current
literature
on
bioavailability
of
sinensetin
derivatives
was
reviewed
potential
ameliorative
effects
metabolic
syndrome
humans
were
evaluated.
mainly
aggregated
large
intestine
metabolized
through
gut
microbiota
(GM)
liver.
So
intestinal
microorganisms
had
a
significant
influence
absorption
metabolism
sinensetin.
Interestingly,
not
only
GM
acted
metabolize
them,
but
also
regulated
composition
GM.
Thus,
as
methyl,
glucuronide
sulfate
metabolites
blood
urine.
Furthermore,
reported
have
beneficial
effect
ameliorating
syndromes,
including
disorders
lipid
(obesity,
NAFLD,
atherosclerosis),
glucose
disorder
(insulin
resistant)
inflammation,
terms
improving
flora
modulating
pathway
factors
relevant
tissues.
present
work
strongly
elucidated
mechanism
supported
contribution
health
benefits,
thus
offering
better
perspective
understanding
role
played
by
human
health.
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1552 - 1552
Опубликована: Дек. 18, 2024
Polyphenols,
plant-derived
secondary
metabolites,
play
crucial
roles
in
plant
stress
responses,
growth
regulation,
and
environmental
interactions.
In
humans,
polyphenols
are
associated
with
various
health
benefits,
particularly
cardiometabolic
health.
Despite
growing
evidence
of
polyphenols’
health-promoting
effects,
their
mechanisms
remain
poorly
understood
due
to
high
interindividual
variability
bioavailability
metabolism.
Recent
research
highlights
the
bidirectional
relationship
between
dietary
gut
microbiota,
which
can
influence
polyphenol
metabolism
and,
conversely,
be
modulated
by
intake.
this
concise
review,
we
summarized
recent
advances
area,
a
special
focus
on
isoflavones
ellagitannins
corresponding
metabotypes,
effect
cardiovascular
Human
observational
studies
published
past
10
years
provide
for
consistent
association
metabotypes
better
risk
factors.
However,
interventional
or
isolated
microbial
metabolites
indicate
that
polyphenol–gut
microbiota
interrelationship
is
complex
not
yet
fully
elucidated.
Finally,
highlighted
pending
questions
will
help
identify
effective
targets
intervention
precision
nutrition,
thus
maximizing
individual
responses
lifestyle
interventions
improving
human
Foods,
Год журнала:
2025,
Номер
14(3), С. 409 - 409
Опубликована: Янв. 27, 2025
The
ultrasound-assisted
extraction
process
with
microwave
pretreatment
was
modeled
and
optimized
to
maximize
the
yield
of
antioxidants
from
green
walnut
husks
using
a
response
surface
methodology
Box–Behnken
design.
In
this
design,
time
(10–40
min),
temperature
(40–60
°C),
(20–60
s)
were
selected
as
factors,
while
total
antioxidant
content
defined
response.
solvent
choice
for
extracting
50%
(v/v)
ethanol.
After
optimization
desirability
function,
an
23
min,
60
°C,
s
proposed
optimal
conditions
their
validity
verified.
Under
these
conditions,
experimentally
determined
3.69
g
gallic
acid
equivalent
per
100
dry
matter.
addition
phenolics,
UHPLC–ESI–MS/MS
analysis
indicated
presence
lipids,
quinones,
terpenoids,
organic
acids
in
extract.
extraction,
solid
residue
further
processed
isolate
cellulose
line
concept
sustainable
manufacturing.
structural
characterization
hydration
properties
analyzed
identify
its
key
features
assess
potential
value-added
applications.
results
demonstrate
that
are
valuable
cost-effective
agro-industrial
byproduct
isolating
cellulose.
This
aligns
principles
circular
economy
production
natural
compounds.
Plant Signaling & Behavior,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 7, 2025
The
exploration
of
plant
signaling
pathways
is
transforming
the
way
diabetes
managed,
providing
new,
multi-target
strategies
for
controlling
this
complex
metabolic
disorder.
Medicinal
plants
are
rich
in
bioactive
compounds
like
phytohormones,
flavonoids
and
polyphenols,
which
regulate
key
including
oxidative
stress,
inflammation,
insulin
resistance,
gut
microbiota
modulation.
Research
emerging
on
therapeutic
potential
Momordica
charantia,
Cinnamomum
verum
Trigonella
foenum-graecum,
enhance
secretion,
sensitivity
glucose
homeostasis.
These
derived
compounds,
resveratrol
based
mimetics,
not
only
address
dysfunction
but
also
offer
holistic
treatment
long
term
complications
such
as
neuropathy
retinopathy.
development
precision
medicine
advances
tailoring
therapies
to
individual
responses,
increasing
efficacy
decreasing
reliance
synthetic
drugs
with
adverse
side
effects.
Despite
challenges
standardization,
regulatory
barriers,
limited
clinical
trials,
incorporating
medicinal
into
national
management
guidelines
represents
a
cost
effective
accessible
option,
particularly
resource
settings.
In
review,
we
highlight
importance
collaborative
work
across
disciplines
use
technologies
artificial
intelligence
speed
research
optimize
patient
specific
applications.
power
harnessed
develop
sustainable,
inclusive,
strategies.