Yellow Himalayan Raspberry (Rubus ellipticus Sm.): Ethnomedicinal, Nutraceutical, and Pharmacological Aspects

Molecules, Год журнала: 2023, Номер 28(16), С. 6071 - 6071

Опубликована: Авг. 15, 2023

Yellow Himalayan raspberry (Rubus ellipticus Sm., Rosaceae) is a native species of the Indian subcontinent, Southern China, and Philippines, which has been historically used as traditional medicine food. All parts this plant have in to treat respiratory ailments, diabetes, gastrointestinal disorder, an anti-infective agent. The scientific evaluation revealed richness macronutrients, micronutrients, minerals fruits, indicating its potential use nutraceutical. Furthermore, found be rich various secondary metabolites, including polyphenols, flavonoids, anthocyanins, tannins, terpenoids. Ascorbic acid, kaempferol, gallic catechin are some compounds plant, widely discussed for their health benefits. extracts obtained from R. shown antioxidant, antidiabetic, anticancer, anti-inflammatory, nephroprotective, antipyretic, anticonvulsant, activities investigated through different study models. These findings literature validated widespread uses fruits folk medicinal systems consumption nutritious wild fruit by local communities. In conclusion, holds strong development It can also improve nutritional status villagers uplift economy if properly utilized marketed.

Язык: Английский

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Role of Driving Force on Engineering Layer-by-Layer Protein/Polyphenol Coating with Flexible Structures and Properties

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(16), С. 20551 - 20562

Опубликована: Апрель 13, 2023

Protein-based coatings are of immense interest due to their rich biological functions. Layer-by-layer (LbL) assembly, as a powerful means transferring protein functions the material surface, has received widespread attention. However, assembly mechanism protein-based LbL is still far from being explained, not only because structure and function diversity but also characterization limitations. Herein, we monitored in situ process tannic acid (TA) lysozyme (Lyz), classic pair polyphenol protein, by combining quartz crystal microbalance with dissipation monitoring (QCM-D) spectroscopic ellipsometry (SE). The water content, morphology, mechanical properties, antioxidant activity, driving force TA-Lyz coating engineered under different pH values were analyzed detail various techniques. key factor coatings, increased increasing assembled values, which resulted porous inhomogeneous distribution, faster growth, better activity both acellular cellular levels. In addition, high content unfavorable entropy enthalpy changes, thermodynamic TA Lyz mainly comes change brought noncovalent interaction between Lyz. These results provide new insights into engineering structure, function, mechanisms coatings.

Язык: Английский

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Natural products targeting amyloid-β oligomer neurotoxicity in Alzheimer's disease

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 276, С. 116684 - 116684

Опубликована: Июль 14, 2024

Язык: Английский

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Dietary sinensetin and polymethoxyflavonoids: Bioavailability and potential metabolic syndrome-related bioactivity

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(27), С. 9992 - 10008

Опубликована: Июнь 7, 2023

Sinensetin is among the most ubiquitous polyphenols in citrus fruit and recently has been extensively studied for its ability to prevent or treat diseases. The current literature on bioavailability of sinensetin derivatives was reviewed potential ameliorative effects metabolic syndrome humans were evaluated. mainly aggregated large intestine metabolized through gut microbiota (GM) liver. So intestinal microorganisms had a significant influence absorption metabolism sinensetin. Interestingly, not only GM acted metabolize them, but also regulated composition GM. Thus, as methyl, glucuronide sulfate metabolites blood urine. Furthermore, reported have beneficial effect ameliorating syndromes, including disorders lipid (obesity, NAFLD, atherosclerosis), glucose disorder (insulin resistant) inflammation, terms improving flora modulating pathway factors relevant tissues. present work strongly elucidated mechanism supported contribution health benefits, thus offering better perspective understanding role played by human health.

Язык: Английский

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Wild Edible Flowers of Western Himalayas: Nutritional Characterization, UHPLC-QTOF-IMS-Based Phytochemical Profiling, Antioxidant Properties, and In Vitro Bioaccessibility of Polyphenols

ACS Omega, Год журнала: 2023, Номер 8(43), С. 40212 - 40228

Опубликована: Окт. 16, 2023

Four edible flowers commonly consumed in the Western Himalayan region, namely, Bauhinia variegata (Kachnar), Tropaeolum majus (Nasturtium), Matricaria chamomilla (Chamomile), and Tagetes erecta (Marigold), were characterized for their nutritional phytochemical composition. Through UHPLC-QTOF-IMS-based metabolomics approach, 131 compounds tentatively identified consisting of phenolic acids, flavonoid glycosides, terpenoids, amino fatty acid derivatives. Kaempferol quercetin glycosides Kachnar, apigenin caffeoylquinic derivatives Chamomile, patulin Marigold, cyanidin delphinidin Nasturtium predicted marker metabolites through non-targeted metabolomics. Kachnar Chamomile scored best terms macronutrients essential micronutrients, respectively. contained high concentrations α-linolenic acid, anthocyanins, lutein. highest total acids (63.36 ± 0.38 mg GAE g-1), while Marigold flavonoids (118.90 1.30 QUE g-1). Marigolds possessed excellent free radical scavenging metal chelation activities. exhibited strong α-glucosidase inhibition activity, followed by Nasturtium. The vitro gastrointestinal digestibility flower extracts indicated that bioaccessibility was higher than flavonoids. Polyphenols from showed bioaccessibility. study is an attempt to characterize traditionally promote wider utilization gastronomy nutraceuticals.

Язык: Английский

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Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1552 - 1552

Опубликована: Дек. 18, 2024

Polyphenols, plant-derived secondary metabolites, play crucial roles in plant stress responses, growth regulation, and environmental interactions. In humans, polyphenols are associated with various health benefits, particularly cardiometabolic health. Despite growing evidence of polyphenols’ health-promoting effects, their mechanisms remain poorly understood due to high interindividual variability bioavailability metabolism. Recent research highlights the bidirectional relationship between dietary gut microbiota, which can influence polyphenol metabolism and, conversely, be modulated by intake. this concise review, we summarized recent advances area, a special focus on isoflavones ellagitannins corresponding metabotypes, effect cardiovascular Human observational studies published past 10 years provide for consistent association metabotypes better risk factors. However, interventional or isolated microbial metabolites indicate that polyphenol–gut microbiota interrelationship is complex not yet fully elucidated. Finally, highlighted pending questions will help identify effective targets intervention precision nutrition, thus maximizing individual responses lifestyle interventions improving human

Язык: Английский

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Oral-gastric digestion effect of emulsion-type ingredient of avocado seed and cytotoxic potential in gastric cancer cell

Food Research International, Год журнала: 2025, Номер 202, С. 115705 - 115705

Опубликована: Янв. 7, 2025

Язык: Английский

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Extraction and Characterization of Antioxidants and Cellulose from Green Walnut Husks

Foods, Год журнала: 2025, Номер 14(3), С. 409 - 409

Опубликована: Янв. 27, 2025

The ultrasound-assisted extraction process with microwave pretreatment was modeled and optimized to maximize the yield of antioxidants from green walnut husks using a response surface methodology Box–Behnken design. In this design, time (10–40 min), temperature (40–60 °C), (20–60 s) were selected as factors, while total antioxidant content defined response. solvent choice for extracting 50% (v/v) ethanol. After optimization desirability function, an 23 min, 60 °C, s proposed optimal conditions their validity verified. Under these conditions, experimentally determined 3.69 g gallic acid equivalent per 100 dry matter. addition phenolics, UHPLC–ESI–MS/MS analysis indicated presence lipids, quinones, terpenoids, organic acids in extract. extraction, solid residue further processed isolate cellulose line concept sustainable manufacturing. structural characterization hydration properties analyzed identify its key features assess potential value-added applications. results demonstrate that are valuable cost-effective agro-industrial byproduct isolating cellulose. This aligns principles circular economy production natural compounds.

Язык: Английский

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Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants

Plant Signaling & Behavior, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 7, 2025

The exploration of plant signaling pathways is transforming the way diabetes managed, providing new, multi-target strategies for controlling this complex metabolic disorder. Medicinal plants are rich in bioactive compounds like phytohormones, flavonoids and polyphenols, which regulate key including oxidative stress, inflammation, insulin resistance, gut microbiota modulation. Research emerging on therapeutic potential Momordica charantia, Cinnamomum verum Trigonella foenum-graecum, enhance secretion, sensitivity glucose homeostasis. These derived compounds, resveratrol based mimetics, not only address dysfunction but also offer holistic treatment long term complications such as neuropathy retinopathy. development precision medicine advances tailoring therapies to individual responses, increasing efficacy decreasing reliance synthetic drugs with adverse side effects. Despite challenges standardization, regulatory barriers, limited clinical trials, incorporating medicinal into national management guidelines represents a cost effective accessible option, particularly resource settings. In review, we highlight importance collaborative work across disciplines use technologies artificial intelligence speed research optimize patient specific applications. power harnessed develop sustainable, inclusive, strategies.

Язык: Английский

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Influence of the maturity on the characteristics of orange-derived extracellular vesicles and their delivery performance for curcumin

Food Chemistry, Год журнала: 2025, Номер 485, С. 144518 - 144518

Опубликована: Апрель 25, 2025

Язык: Английский

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