Tiger nut/coconut dietary intervention as antidotal nutritional remediation strategy against neurobehavioural deficits following organophosphate-induced gut-brain axis dysregulation in mice DOI Creative Commons

Linus Anderson Enye,

Edem Ekpenyong Edem,

Lydia Ijeoma Onyeogaziri

et al.

Toxicology Reports, Journal Year: 2023, Volume and Issue: 12, P. 23 - 40

Published: Dec. 9, 2023

Organophosphate poisoning remains a global health crisis without efficacious treatments to prevent neurotoxicity. We examined whether antidotal tiger nut and coconut dietary intervention could ameliorate neurobehavioral deficits from organophosphate dichlorvos-induced gut-brain axis dysregulation in mouse model. Mice were divided into groups given control diet, dichlorvos-contaminated diets, or dichlorvos plus nut-enriched diets. They exposed DDVP-contaminated diet for 4 weeks before exposure the treatment diets another 8 weeks. This was followed by behavioural assessments cognitive, motor, anxiety-, depressive-like behaviours. Faecal samples (pre- post-treatment), as well blood, brain, gut tissues, collected biochemical following euthanasia. Dichlorvos-exposed mice displayed impairments cognition, motor function, mood along with disrupted inflammatory antioxidant responses, neurotrophic factor levels, acetylcholinesterase activity brain intestinal tissues. Weight loss altered short-chain fatty acid levels additionally indicated dysfunction. However, and/or coconut- enriched after attenuated these neurobehavioral, alterations. Our findings demonstrate organophosphate-induced communication disruptions between pathways that manifest neuropsychiatric disturbances. Overall, incorporating fibre-rich nuts may represent an strategy reduce neurotoxicity disorders associated poisoning.

Language: Английский

Yellow Himalayan Raspberry (Rubus ellipticus Sm.): Ethnomedicinal, Nutraceutical, and Pharmacological Aspects DOI Creative Commons
Ananda Lamichhane, Gopal Lamichhane, Hari Prasad Devkota

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6071 - 6071

Published: Aug. 15, 2023

Yellow Himalayan raspberry (Rubus ellipticus Sm., Rosaceae) is a native species of the Indian subcontinent, Southern China, and Philippines, which has been historically used as traditional medicine food. All parts this plant have in to treat respiratory ailments, diabetes, gastrointestinal disorder, an anti-infective agent. The scientific evaluation revealed richness macronutrients, micronutrients, minerals fruits, indicating its potential use nutraceutical. Furthermore, found be rich various secondary metabolites, including polyphenols, flavonoids, anthocyanins, tannins, terpenoids. Ascorbic acid, kaempferol, gallic catechin are some compounds plant, widely discussed for their health benefits. extracts obtained from R. shown antioxidant, antidiabetic, anticancer, anti-inflammatory, nephroprotective, antipyretic, anticonvulsant, activities investigated through different study models. These findings literature validated widespread uses fruits folk medicinal systems consumption nutritious wild fruit by local communities. In conclusion, holds strong development It can also improve nutritional status villagers uplift economy if properly utilized marketed.

Language: Английский

Citations

12
Biochemical Compounds, Antioxidant Capacity, Leaf Color Profile and Yield of Basil (Ocimum sp.) Microgreens in Floating System DOI Creative Commons

Mohammad Reza Fayezizadeh,

Naser Alemzadeh Ansari,

Mohammad Mahmoudi Sourestani

et al.

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2652 - 2652

Published: July 14, 2023

Basil is a great source of phytochemicals such as polyphenols, vitamin C, anthocyanin, and flavonoids. In this work, the biochemical compounds, antioxidant capacity, leaf color profile, yield 21 cultivars genotypes basil microgreen were investigated. Results showed that highest potential composite index (APCI) was measured in Persian Ablagh genotype (70.30). Twenty-one classified into four clusters, including cluster 1 (lowest capacity total phenolic compounds), 2 C APCI index), 3 (highest 4 levels anthocyanin). The principal components analysis (PCA) diversity terms phytochemical components, F1, F2, F3, F4 explained variation at rate 78.12%. average annual temperature origin seeds plays an important role synthesis content. Most with moderate had higher index. genotype, Violeto, Kapoor can be recommended, according to their yield. These used individually or different ratios produce substances concentrations for various purposes.

Language: Английский

Citations

11
Natural products targeting amyloid-β oligomer neurotoxicity in Alzheimer's disease DOI
Priscila Baltazar Gonçalves, Ana Carolina Rennó Sodero, Yraima Cordeiro

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116684 - 116684

Published: July 14, 2024

Language: Английский

Citations

4
Oral-gastric digestion effect of emulsion-type ingredient of avocado seed and cytotoxic potential in gastric cancer cell DOI
Guadalupe Loarca‐Piña, J. Núñez, Minerva Ramos‐Gómez

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 202, P. 115705 - 115705

Published: Jan. 7, 2025

Language: Английский

Citations

0
Extraction and Characterization of Antioxidants and Cellulose from Green Walnut Husks DOI Creative Commons
Ivan Savić, Ivana Savić

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 409 - 409

Published: Jan. 27, 2025

The ultrasound-assisted extraction process with microwave pretreatment was modeled and optimized to maximize the yield of antioxidants from green walnut husks using a response surface methodology Box–Behnken design. In this design, time (10–40 min), temperature (40–60 °C), (20–60 s) were selected as factors, while total antioxidant content defined response. solvent choice for extracting 50% (v/v) ethanol. After optimization desirability function, an 23 min, 60 °C, s proposed optimal conditions their validity verified. Under these conditions, experimentally determined 3.69 g gallic acid equivalent per 100 dry matter. addition phenolics, UHPLC–ESI–MS/MS analysis indicated presence lipids, quinones, terpenoids, organic acids in extract. extraction, solid residue further processed isolate cellulose line concept sustainable manufacturing. structural characterization hydration properties analyzed identify its key features assess potential value-added applications. results demonstrate that are valuable cost-effective agro-industrial byproduct isolating cellulose. This aligns principles circular economy production natural compounds.

Language: Английский

Citations

0
Influence of the maturity on the characteristics of orange-derived extracellular vesicles and their delivery performance for curcumin DOI
Huan Liu, Yang Chen,

Xiaolin Wu

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144518 - 144518

Published: April 1, 2025

Language: Английский

Citations

0
A sustainable technology for enhancing the oxidative stability of edible oils using jackfruit (Artocarpus heterophyllus lam.) peel extract as a natural antioxidant DOI

Rajkesh Koundal,

Anil Kumar Chauhan,

Rahul Das

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 485, P. 144564 - 144564

Published: April 29, 2025

Language: Английский

Citations

0
Wild Edible Flowers of Western Himalayas: Nutritional Characterization, UHPLC-QTOF-IMS-Based Phytochemical Profiling, Antioxidant Properties, and In Vitro Bioaccessibility of Polyphenols DOI Creative Commons
Athrinandan S. Hegde, Smriti Gupta, Poonam Kumari

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(43), P. 40212 - 40228

Published: Oct. 16, 2023

Four edible flowers commonly consumed in the Western Himalayan region, namely, Bauhinia variegata (Kachnar), Tropaeolum majus (Nasturtium), Matricaria chamomilla (Chamomile), and Tagetes erecta (Marigold), were characterized for their nutritional phytochemical composition. Through UHPLC-QTOF-IMS-based metabolomics approach, 131 compounds tentatively identified consisting of phenolic acids, flavonoid glycosides, terpenoids, amino fatty acid derivatives. Kaempferol quercetin glycosides Kachnar, apigenin caffeoylquinic derivatives Chamomile, patulin Marigold, cyanidin delphinidin Nasturtium predicted marker metabolites through non-targeted metabolomics. Kachnar Chamomile scored best terms macronutrients essential micronutrients, respectively. contained high concentrations α-linolenic acid, anthocyanins, lutein. highest total acids (63.36 ± 0.38 mg GAE g-1), while Marigold flavonoids (118.90 1.30 QUE g-1). Marigolds possessed excellent free radical scavenging metal chelation activities. exhibited strong α-glucosidase inhibition activity, followed by Nasturtium. The vitro gastrointestinal digestibility flower extracts indicated that bioaccessibility was higher than flavonoids. Polyphenols from showed bioaccessibility. study is an attempt to characterize traditionally promote wider utilization gastronomy nutraceuticals.

Language: Английский

Citations

10
Polyphenol-Derived Microbiota Metabolites and Cardiovascular Health: A Concise Review of Human Studies DOI Creative Commons
Ana Clara da C. Pinaffi‐Langley, Stefano Tarantini, Norman G. Hord

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1552 - 1552

Published: Dec. 18, 2024

Polyphenols, plant-derived secondary metabolites, play crucial roles in plant stress responses, growth regulation, and environmental interactions. In humans, polyphenols are associated with various health benefits, particularly cardiometabolic health. Despite growing evidence of polyphenols’ health-promoting effects, their mechanisms remain poorly understood due to high interindividual variability bioavailability metabolism. Recent research highlights the bidirectional relationship between dietary gut microbiota, which can influence polyphenol metabolism and, conversely, be modulated by intake. this concise review, we summarized recent advances area, a special focus on isoflavones ellagitannins corresponding metabotypes, effect cardiovascular Human observational studies published past 10 years provide for consistent association metabotypes better risk factors. However, interventional or isolated microbial metabolites indicate that polyphenol–gut microbiota interrelationship is complex not yet fully elucidated. Finally, highlighted pending questions will help identify effective targets intervention precision nutrition, thus maximizing individual responses lifestyle interventions improving human

Language: Английский

Citations

3
Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants DOI Creative Commons
Okechukwu Paul-Chima Ugwu,

Anyanwu Chinyere Nkemjika,

M. N. Ugwu

et al.

Plant Signaling & Behavior, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 7, 2025

The exploration of plant signaling pathways is transforming the way diabetes managed, providing new, multi-target strategies for controlling this complex metabolic disorder. Medicinal plants are rich in bioactive compounds like phytohormones, flavonoids and polyphenols, which regulate key including oxidative stress, inflammation, insulin resistance, gut microbiota modulation. Research emerging on therapeutic potential Momordica charantia, Cinnamomum verum Trigonella foenum-graecum, enhance secretion, sensitivity glucose homeostasis. These derived compounds, resveratrol based mimetics, not only address dysfunction but also offer holistic treatment long term complications such as neuropathy retinopathy. development precision medicine advances tailoring therapies to individual responses, increasing efficacy decreasing reliance synthetic drugs with adverse side effects. Despite challenges standardization, regulatory barriers, limited clinical trials, incorporating medicinal into national management guidelines represents a cost effective accessible option, particularly resource settings. In review, we highlight importance collaborative work across disciplines use technologies artificial intelligence speed research optimize patient specific applications. power harnessed develop sustainable, inclusive, strategies.

Language: Английский

Citations

0