Caffeic acid, a dietary polyphenol, pre-sensitizes pancreatic ductal adenocarcinoma to chemotherapeutic drug DOI
Shruti Gupta, Harshita Tak, Khushhal Rathore

и другие.

Journal of Biomolecular Structure and Dynamics, Год журнала: 2024, Номер unknown, С. 1 - 15

Опубликована: Фев. 22, 2024

Resistance to chemotherapeutics is an eminent cause that leads search for options help in diminution of pancreatic ductal adenocarcinoma (PDAC) by overcoming resistance issues. Caffeic acid (CFA), a polyphenol occurring many dietary foods, known show antidiabetic and anticancer properties potential. To unveil the effect CFA on PDAC, we carried out this research PDAC cells, following which checked combination pre-sensitization effects CFA. Multitudinous web-based approaches were applied identifying targets then getting their interconnections. Subsequently, manifested in-vitro analysis showing IC50 concentrations 37.37 15.06 µM Panc-1 Mia-PaCa-2, respectively. The index with different drugs was explored showed antagonistic treatment leading further investigation pre-sensitizing effects. reduced concentration doxorubicin both cell lines also triggered ROS generation determined 2′,7′-dichlorofluorescin diacetate assay. differential gene expression after discrete genes affected i.e. N-Cad Cas9 Pi3K/AkT/mTOR along p53 Mia-PaCa-2. Collectively, study investigated role as therapeutics mechanism mitigating sensitizing chemotherapeutics.

Язык: Английский

A sustainable technology for enhancing the oxidative stability of edible oils using jackfruit (Artocarpus heterophyllus lam.) peel extract as a natural antioxidant DOI

Rajkesh Koundal,

Anil Kumar Chauhan,

Rahul Das

и другие.

Food Chemistry, Год журнала: 2025, Номер 485, С. 144564 - 144564

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0
Recent advances in microbial synthesis of polyphenols DOI

Yuxiang Hong,

Pornpatsorn Lertphadungkit,

Yongkun Lv

и другие.

Current Opinion in Biotechnology, Год журнала: 2025, Номер 93, С. 103308 - 103308

Опубликована: Май 5, 2025

Язык: Английский

Процитировано

0
Polyphenol intake and risk for dementia and cognitive decline in the elderly population of Greece: A principal component analysis approach DOI

Stelios Chatzispyrellis,

Elizabeth Fragopoulou, Eirini Mamalaki

и другие.

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Development and validation of a LC–MS/MS method for the quantification of phenolic compounds in human saliva after intake of a procyanidin-rich pine bark extract DOI

Jasmin Bayer,

Petra Högger

Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2023, Номер 239, С. 115914 - 115914

Опубликована: Дек. 9, 2023

Язык: Английский

Процитировано

7
Caffeic acid, a dietary polyphenol, pre-sensitizes pancreatic ductal adenocarcinoma to chemotherapeutic drug DOI
Shruti Gupta, Harshita Tak, Khushhal Rathore

и другие.

Journal of Biomolecular Structure and Dynamics, Год журнала: 2024, Номер unknown, С. 1 - 15

Опубликована: Фев. 22, 2024

Resistance to chemotherapeutics is an eminent cause that leads search for options help in diminution of pancreatic ductal adenocarcinoma (PDAC) by overcoming resistance issues. Caffeic acid (CFA), a polyphenol occurring many dietary foods, known show antidiabetic and anticancer properties potential. To unveil the effect CFA on PDAC, we carried out this research PDAC cells, following which checked combination pre-sensitization effects CFA. Multitudinous web-based approaches were applied identifying targets then getting their interconnections. Subsequently, manifested in-vitro analysis showing IC50 concentrations 37.37 15.06 µM Panc-1 Mia-PaCa-2, respectively. The index with different drugs was explored showed antagonistic treatment leading further investigation pre-sensitizing effects. reduced concentration doxorubicin both cell lines also triggered ROS generation determined 2′,7′-dichlorofluorescin diacetate assay. differential gene expression after discrete genes affected i.e. N-Cad Cas9 Pi3K/AkT/mTOR along p53 Mia-PaCa-2. Collectively, study investigated role as therapeutics mechanism mitigating sensitizing chemotherapeutics.

Язык: Английский

Процитировано

2