Aspergillus Mycotoxins: The Major Food Contaminants

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Mycotoxins, a category of fungal secondary metabolites, frequently contaminate food products and pose severe threat to human health. Aspergillus, genus fungi, is capable producing mycotoxins, with aflatoxins (AFs) ochratoxins being its principal types. Aspergillus mycotoxins can wide range crops their derivatives, such as maize, wheat, rice, minor cereals, peanuts, thereby threatening feed safety. In the paper, related biosynthesis genes multifaceted pathways these are first discussed in detail, elucidated several global regulators, including growth conditions, oxidative stress, cell signal. Furthermore, how shifts temperature water availability, driven by climate change (including rising temperatures, increased heavy rainfall frequency, prolonged droughts, elevated carbon dioxide levels), key determinants proliferation mycotoxin production explored. Finally, safeguard animal health from detrimental impacts effective convenient analytical techniques management strategies for detection prevention contamination analyzed. Overall, this review provides promising solutions which great significance ensuring security protecting people's lives

Язык: Английский

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Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection

Toxins, Год журнала: 2025, Номер 17(1), С. 24 - 24

Опубликована: Янв. 6, 2025

Food contamination with mycotoxin-producing fungi increases the risk of many diseases, including neurological diseases closely related to neurotoxicity these toxins. Based on latest literature data, we presented association common Fusarium mycotoxins diseases. Articles from 2001 2024 were analyzed. The mechanisms underlying described presented. They are mainly increase in oxidative stress neuronal cells, which leads higher levels pro-inflammatory cytokines as IL-1β, IL-6 and TNF-α, enzymatic activity GST, GPx, CAT SOD neurotransmitter dysfunction (5-HT, serotonin, dopamine GABA). At end article, based attempted present ways mitigate mycotoxin using natural substances plant origin. data this review focus most frequently found food will be useful comparative information for future studies. It is important conduct further studies neurotoxic effects order reduce development nervous system.

Язык: Английский

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Mycotoxins and bone growth: a review of the literature on associations between xenobiotic exposure and bone growth and development

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Апрель 5, 2024

Abstract Mycotoxins are secondary metabolites of fungi that known to be associated with linear growth faltering because their impact on inflammation, intestinal damage, inhibition protein synthesis, and micronutrient absorption. In this narrative review, we aim extend analysis further explore associations between mycotoxins (aflatoxins, ochratoxins, trichothecenes including deoxynivalenol, T-2 toxin, fumonisins) long-bone growth, particularly during the saltatory periods development. Linear is a direct function skeletal development growth. We therefore explored biological pathways mechanisms these toxins in both animal human studies, addition epidemiology literature (post-2020). Given what effects individual combinations based literature, have identified need for research examination how exposures may studied humans elucidate downstream bone-related biomarkers anthropometric indices used identify predict stunting population-based studies.

Язык: Английский

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Association between anaemia and aflatoxin B1 and fumonisin B1 exposure in HIV-infected and HIV-uninfected pregnant women from Harare, Zimbabwe

Mycotoxin Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 16, 2024

Язык: Английский

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Aflatoxin B ₁ and fumonisin B ₁ exposure and adverse birth outcomes in HIV-infected and HIV-uninfected women from Harare, Zimbabwe

Drug and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Янв. 4, 2025

Aflatoxin B1 (AFB1) and fumonisin (FB1) are toxic secondary products of fungi that frequently contaminate staple crops in resource-limited settings. Antenatal AFB1 FB1 exposure may cause adverse birth outcomes. We conducted a retrospective substudy nested case-control cohort HIV-infected HIV-uninfected women ≥20 weeks gestation from Harare, Zimbabwe. Urinary aflatoxin M1 (AFM1) FB1, biomarkers exposure, respectively, were quantified random antenatal urine via ELISA grouped into tertiles. The outcomes considered low weight, preterm (PTB), small for gestational age, stillbirth, defects, neonatal death, jaundice perinatal death (PD). evaluated any associations between to AFB1, or the AFB1-FB1 combination multivariable logistic regression controlled potential confounders. enrolled 94 81 women. In HIV-infected, AFM1 was detected 46/94 (49%), 86/94 (91%). HIV-uninfected, 48/81 (59%), 74/81 Among all women, tertile 3 associated with PD (OR: 6.95; 95% CI: 1.21-39.78). same population, tertiles 2 13.46; 1.20-150.11) 7.92; 1.08-58.19) PTB. PTB 64.73; 2.37-177.93). Our results revealed an association including those infected HIV. Public health nutrition measures necessary mitigate mycotoxins.

Язык: Английский

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Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 28, 2023

Deoxynivalenol (DON), one of the most prevalent mycotoxins, has been found to cause fetal growth retardation in animals. However, limited evidence exists regarding its effects on pregnant women.Maternal urinary concentration total DON (tDON) and free (fDON) second trimester was measured using liquid chromatography with tandem mass spectrometry. Provisional daily intake (PDI) calculated based tDON concentration. Linear logistic regression models were used evaluate association between exposure levels birth weight, length, risk small for gestational age (SGA).Among 1538 subjects, median concentrations fDON 12.1 ng/mL 5.1 ng/mL, respectively. The PDI values revealed that 0.7 µg/kg bw, 35.9% population exceeded provisional maximum tolerable (PMTDI) 1 bw. Compared lowest tertile, weight decreased by 81.11 g (95% CI: -127.00, -35.23) (P-trend < 0.001) 63.02 -108.72, -17.32) = 0.004) highest tertile. Each unit increase Ln-tDON Ln-fDON also inversely associated weight. Furthermore, compared those who did not exceed PMTDI, women whose PMTDI had lower (β -79.79 g; 95% -119.09, -40.49) length -0.21 cm; -0.34, -0.07), a higher SGA (OR 1.48; 1.02, 2.15) their offspring. Similar associations when comparing tertile (all P-trend 0.05).Maternal is related Our findings implicate during pregnancy may faltering, measures should be taken reduce women.

Язык: Английский

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Maternal serum biomarkers of placental insufficiency at 24–28 weeks of pregnancy in relation to the risk of delivering small-for-gestational-age infant in Sylhet, Bangladesh: a prospective cohort study

BMC Pregnancy and Childbirth, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 10, 2024

Язык: Английский

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Seed Priming with Rhizospheric Bacillus subtilis: A Smart Strategy for Reducing Fumonisin Contamination in Pre-Harvest Maize

Toxins, Год журнала: 2024, Номер 16(8), С. 337 - 337

Опубликована: Июль 31, 2024

Maize, one of the most important cereal crops in Bangladesh, is severely contaminated by fumonisin, a carcinogenic secondary metabolite produced

Язык: Английский

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Integrating a Multiple Isotopologue Reaction-Monitoring Technique and LC-MS/MS for Quantitation of Small Molecules: Ten Mycotoxins in Cereals as an Example

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(12), С. 6638 - 6650

Опубликована: Март 14, 2024

Accurate quantification of mycotoxin in cereals is crucial for ensuring food safety and human health. However, the preparation traditional multisample external calibration curves (MSCCs) labor-intensive error-prone. Here, a multiple isotopologue reaction-monitoring (MIRM)-LC-MS/MS method accurate quantitation ten major mycotoxins was successfully developed validated, where novel one-sample multipoint curve (OSCC) strategy used instead MSCCs. The OSCC can be established by examining correlation between calculated theoretical isotopic abundances measured abundance across various MIRM channels. In comparison to MSCC, exhibits outstanding performance including superior selectivity, accuracy (78.4–108.6%), precision (<12.5%). Furthermore, proposed OSCC-MIRM-LC-MS/MS applied investigate contamination cereal samples China. Considering advantages simplified workflows improved throughput, methodology holds great promise accurately quantifying chemical contaminants foods.

Язык: Английский

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Ochratoxin A status at birth is associated with reduced birth weight and ponderal index in rural Burkina Faso

Journal of Nutrition, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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