Two- and Three-Dimensional Culture Systems: Respiratory In Vitro Tissue Models for Chemical Screening and Risk-Based Decision Making

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 113 - 113

Опубликована: Янв. 16, 2025

Risk of lung damage from inhaled chemicals or substances has long been assessed using animal models. However, New Approach Methodologies (NAMs) that replace, reduce, and/or refine the use animals in safety testing such as 2D and 3D cultures are increasingly being used to understand human-relevant toxicity responses for assessment hazard identification. Here we review models terms their application inhalation assessment. We highlight a key case study Organization Economic Cooperation Development (OECD), which model was assess human replace requirement 90-day rats. Finally, consider regulatory guidelines NAMs potential different aerosol studies depending on requirement/context use.

Язык: Английский

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Uptake, localization and dissolution of barium sulfate nanoparticles in human lung cells explored by the combination of ICP-MS, TEM and NanoSIMS

Journal of Trace Elements in Medicine and Biology, Год журнала: 2025, Номер unknown, С. 127650 - 127650

Опубликована: Апрель 1, 2025

Язык: Английский

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Development of a smoking simulation machine to evaluate the effects of smoking on the color change of dental restorative materials

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 28, 2025

Abstract To develop a smoking simulation machine, the study evaluated effects of conventional and electronic cigarette smoke on color stability resin-based composites. Two types nanohybrid composites were divided into two groups based material subgroups according to kind exposure: cigarettes, control. The exposure was by using newly developed change primary outcome, measured with spectrophotometer calculated ΔEab. results showed significant differences in observed between ( p < 0.001). Specimens exposed cigarettes exhibited more discoloration compared those custom-made machine demonstrated ability simulate conditions their dental materials. provides standard controlled method for evaluating smoke’s restorative materials, while not all materials similar reactions under same conditions. impacts testing accurately simulates oral environment, providing insights performance that helps formulate resist tobacco smoke, improve restoration durability esthetics, enhance patient outcomes, guide selection.

Язык: Английский

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A Novel “Cells-on-Particles” Cytotoxicity Testing Platform In vitro: Design, Characterization, and Validation against Engineered Nanoparticle Aerosol

Toxicology, Год журнала: 2024, Номер 508, С. 153936 - 153936

Опубликована: Авг. 30, 2024

Язык: Английский

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Nanomaterials in the environment and their pragmatic voyage at various trophic levels in an ecosystem

Journal of Environmental Management, Год журнала: 2024, Номер 364, С. 121307 - 121307

Опубликована: Июнь 12, 2024

Язык: Английский

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