Nanomaterials in the environment and their pragmatic voyage at various trophic levels in an ecosystem DOI
Jayshree Annamalai, Barathi Seetharaman,

Iyappan Sellamuthu

et al.

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 364, P. 121307 - 121307

Published: June 12, 2024

Language: Английский

Two- and Three-Dimensional Culture Systems: Respiratory In Vitro Tissue Models for Chemical Screening and Risk-Based Decision Making DOI Creative Commons
Joanne Wallace,

Mary McElroy,

Mitchell Klausner

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 113 - 113

Published: Jan. 16, 2025

Risk of lung damage from inhaled chemicals or substances has long been assessed using animal models. However, New Approach Methodologies (NAMs) that replace, reduce, and/or refine the use animals in safety testing such as 2D and 3D cultures are increasingly being used to understand human-relevant toxicity responses for assessment hazard identification. Here we review models terms their application inhalation assessment. We highlight a key case study Organization Economic Cooperation Development (OECD), which model was assess human replace requirement 90-day rats. Finally, consider regulatory guidelines NAMs potential different aerosol studies depending on requirement/context use.

Language: Английский

Citations

0
Uptake, localization and dissolution of barium sulfate nanoparticles in human lung cells explored by the combination of ICP-MS, TEM and NanoSIMS DOI Creative Commons
Maria Angels Subirana, Sarah Thomas, Gerd Hause

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127650 - 127650

Published: April 1, 2025

Language: Английский

Citations

0
Development of a smoking simulation machine to evaluate the effects of smoking on the color change of dental restorative materials DOI Creative Commons

Ali Nadm Hmood,

Maha M. Ebaya, Abeer Elsayed Elembaby

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 28, 2025

Abstract To develop a smoking simulation machine, the study evaluated effects of conventional and electronic cigarette smoke on color stability resin-based composites. Two types nanohybrid composites were divided into two groups based material subgroups according to kind exposure: cigarettes, control. The exposure was by using newly developed change primary outcome, measured with spectrophotometer calculated ΔEab. results showed significant differences in observed between ( p < 0.001). Specimens exposed cigarettes exhibited more discoloration compared those custom-made machine demonstrated ability simulate conditions their dental materials. provides standard controlled method for evaluating smoke’s restorative materials, while not all materials similar reactions under same conditions. impacts testing accurately simulates oral environment, providing insights performance that helps formulate resist tobacco smoke, improve restoration durability esthetics, enhance patient outcomes, guide selection.

Language: Английский

Citations

0
A Novel “Cells-on-Particles” Cytotoxicity Testing Platform In vitro: Design, Characterization, and Validation against Engineered Nanoparticle Aerosol DOI
Edvinas Krugly, Edvardas Bagdonas,

Jovilė Raudoniūtė

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 508, P. 153936 - 153936

Published: Aug. 30, 2024

Language: Английский

Citations

2
Nanomaterials in the environment and their pragmatic voyage at various trophic levels in an ecosystem DOI
Jayshree Annamalai, Barathi Seetharaman,

Iyappan Sellamuthu

et al.

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 364, P. 121307 - 121307

Published: June 12, 2024

Language: Английский

Citations

1