Revista Eletrônica Acervo Saúde,
Год журнала:
2024,
Номер
24(11), С. e16907 - e16907
Опубликована: Ноя. 30, 2024
Objective:
Summarizes
the
current
knowledge
on
ageusia/dysgeusia
in
post-COVID
patients
focusing
taste
pathway
as
a
possible
gateway
for
central
nervous.
Literature
review:
Observational
studies
have
revealed
that
loss
of
smell
and
may
be
more
predictive
diagnosis
COVID-19
than
other
symptoms
such
fatigue,
fever
or
cough.
Taste
dysfunction
was
associated
with
moderate
infection.
The
duration
is
seven
days
average,
almost
all
recover
within
month.
However,
there
are
reports
whose
has
not
returned
to
normal
prolonged
periods
after
infection
still
alterations
certain
flavors.
Final
considerations:
mechanisms
by
which
these
occur
yet
well
clarified,
but
it
known
neuroinvasive
potential
SARS-CoV-2
play
role
pathophysiology
alterations,
due
hyperinflammatory
state,
viral
invasion
peripheral
nervous
system,
post-infection
immune
reactions.
Biomedicines,
Год журнала:
2023,
Номер
11(8), С. 2287 - 2287
Опубликована: Авг. 17, 2023
The
COVID-19
pandemic
caused
much
illness,
many
deaths,
and
profound
disruption
to
society.
production
of
‘safe
effective’
vaccines
was
a
key
public
health
target.
Sadly,
unprecedented
high
rates
adverse
events
have
overshadowed
the
benefits.
This
two-part
narrative
review
presents
evidence
for
widespread
harms
novel
product
mRNA
adenovectorDNA
is
in
attempting
provide
thorough
overview
arising
from
new
technology
that
relied
on
human
cells
producing
foreign
antigen
has
pathogenicity.
first
paper
explores
peer-reviewed
data
counter
attached
these
technologies.
Spike
protein
pathogenicity,
termed
‘spikeopathy’,
whether
SARS-CoV-2
virus
or
produced
by
vaccine
gene
codes,
akin
‘synthetic
virus’,
increasingly
understood
terms
molecular
biology
pathophysiology.
Pharmacokinetic
transfection
through
body
tissues
distant
injection
site
lipid-nanoparticles
viral-vector
carriers
means
‘spikeopathy’
can
affect
organs.
inflammatory
properties
nanoparticles
used
ferry
mRNA;
N1-methylpseudouridine
employed
prolong
synthetic
function;
biodistribution
DNA
codes
translated
spike
proteins,
autoimmunity
via
contribute
harmful
effects.
reviews
autoimmune,
cardiovascular,
neurological,
potential
oncological
effects,
autopsy
spikeopathy.
With
gene-based
therapeutic
technologies
planned,
re-evaluation
necessary
timely.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 27, 2024
Abstract
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
as
result
of
the
degeneration
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNpc).
The
fundamental
features
PD
are
motor
and
non-motor
symptoms.
symptoms
develop
due
to
disruption
neurotransmitters
other
such
γ-aminobutyric
acid
(GABA).
potential
role
GABA
neuropathology
concerning
was
not
precisely
discussed.
Therefore,
this
review
intended
illustrate
possible
regarding
pathway
essential
regulating
inhibitory
tone
prevent
excessive
stimulation
cerebral
cortex.
Degeneration
linked
with
reducing
GABAergic
neurotransmission.
Decreasing
activity
promotes
mitochondrial
dysfunction
oxidative
stress,
which
highly
related
neuropathology.
Hence,
restoring
by
agonists
may
attenuate
progression
dysregulation
SNpc
contributes
developing
Besides,
also
pathway,
amelioration
reduce
In
conclusion,
deregulation
might
be
intricate
Improving
novel,
beneficial
approach
control
Inflammopharmacology,
Год журнала:
2022,
Номер
31(1), С. 37 - 56
Опубликована: Дек. 29, 2022
Abstract
Silent
information
regulator
(SIRT)
has
distinctive
enzymatic
activities
and
physiological
functions
to
control
cell-cycle
progression,
gene
expression,
DNA
stability
by
targeting
histone
non-histone
proteins.
SIRT1
enhances
synaptic
formation
activity,
therefore,
can
reduce
the
progression
of
various
degenerative
brain
diseases
including
Parkinson’s
disease
(PD).
activity
is
decreased
aging
with
a
subsequent
increased
risk
for
development
diseases.
Inhibition
promotes
inflammatory
reactions
since
inhibits
transcription
nuclear
factor
kappa
B
(NF-κB)
which
also
activation
via
microRNA
miR-34a
NAD
synthesis.
highly
expressed
in
microglia
as
well
neurons,
antioxidant
anti-inflammatory
effects.
Therefore,
this
review
aimed
find
possible
role
PD
neuropathology.
neuroprotective
effects;
downregulation
during
p53
expression
may
increase
vulnerability
neuronal
cell
deaths.
neuropathology
linked
sequence
changes
release
pro-inflammatory
cytokines
due
signaling
pathways.
In
addition,
oxidative
stress,
disorders,
mitochondrial
dysfunction,
apoptosis
contribute
mutually
Thus,
activators
play
crucial
mitigation
through
amelioration
apoptosis,
Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 31, 2023
COVID-19,
caused
by
the
SARS-CoV-2
virus,
is
a
respiratory
infectious
disease.
While
most
patients
recover
after
treatment,
there
growing
evidence
that
COVID-19
may
result
in
cognitive
impairment.
Recent
studies
reveal
some
individuals
experience
deficits,
such
as
diminished
memory
and
attention,
well
sleep
disturbances,
suggesting
could
have
long-term
effects
on
function.
Research
indicates
contribute
to
decline
damaging
crucial
brain
regions,
including
hippocampus
anterior
cingulate
cortex.
Additionally,
identified
active
neuroinflammation,
mitochondrial
dysfunction,
microglial
activation
patients,
implying
these
factors
be
potential
mechanisms
leading
Given
findings,
possibility
of
impairment
following
treatment
warrants
careful
consideration.
Large-scale
follow-up
are
needed
investigate
impact
function
offer
support
clinical
rehabilitation
practices.
In-depth
neuropathological
biological
can
elucidate
precise
provide
theoretical
basis
for
prevention,
intervention
research.
Considering
risks
reinfection,
it
imperative
integrate
basic
research
data
optimize
preservation
patients'
quality
life.
This
integration
will
also
valuable
insights
responding
similar
public
health
events
future.
perspective
article
synthesizes
discussing
outlining
future
directions.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Фев. 9, 2024
Abstract
Multiple
sclerosis
(MS)
is
the
most
frequent
inflammatory
and
demyelinating
disease
of
central
nervous
system
(CNS).
The
underlying
pathophysiology
MS
destruction
myelin
sheath
by
immune
cells.
formation
plaques,
inflammation,
injury
neuronal
characterizes
its
neuropathology.
plaques
are
multiple
focal
regions
demyelination
disseminated
in
brain's
white
matter,
spinal
cords,
deep
grey
cerebral
cortex.
Fenofibrate
a
peroxisome
proliferative
activated
receptor
alpha
(PPAR-α)
that
attenuates
reactions
MS.
inhibits
differentiation
Th17
inhibiting
expression
pro-inflammatory
signaling.
According
to
these
findings,
this
review
intended
illuminate
mechanistic
immunoinflammatory
role
fenofibrate
mitigating
In
conclusion,
can
attenuate
neuropathology
modulating
different
pathways,
including
oxidative
stress,
autophagy,
mitochondrial
dysfunction,
inflammatory-signaling
neuroinflammation.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 15, 2023
Myalgic
Encephalomyelitis/Chronic
Fatigue
Syndrome
(ME/CFS)
and
post-COVID
condition
can
present
similarities
such
as
fatigue,
brain
fog,
autonomic
neuropathic
symptoms.
