Ageusia/Dysgeusia in post-COVID-19 patients DOI Open Access
Márcio Luís Valença Araújo

Revista Eletrônica Acervo Saúde, Год журнала: 2024, Номер 24(11), С. e16907 - e16907

Опубликована: Ноя. 30, 2024

Objective: Summarizes the current knowledge on ageusia/dysgeusia in post-COVID patients focusing taste pathway as a possible gateway for central nervous. Literature review: Observational studies have revealed that loss of smell and may be more predictive diagnosis COVID-19 than other symptoms such fatigue, fever or cough. Taste dysfunction was associated with moderate infection. The duration is seven days average, almost all recover within month. However, there are reports whose has not returned to normal prolonged periods after infection still alterations certain flavors. Final considerations: mechanisms by which these occur yet well clarified, but it known neuroinvasive potential SARS-CoV-2 play role pathophysiology alterations, due hyperinflammatory state, viral invasion peripheral nervous system, post-infection immune reactions.

Язык: Английский

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA DOI Creative Commons
Peter Parry,

Astrid Lefringhausen,

Conny Turni

и другие.

Biomedicines, Год журнала: 2023, Номер 11(8), С. 2287 - 2287

Опубликована: Авг. 17, 2023

The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. production of ‘safe effective’ vaccines was a key public health target. Sadly, unprecedented high rates adverse events have overshadowed the benefits. This two-part narrative review presents evidence for widespread harms novel product mRNA adenovectorDNA is in attempting provide thorough overview arising from new technology that relied on human cells producing foreign antigen has pathogenicity. first paper explores peer-reviewed data counter attached these technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether SARS-CoV-2 virus or produced by vaccine gene codes, akin ‘synthetic virus’, increasingly understood terms molecular biology pathophysiology. Pharmacokinetic transfection through body tissues distant injection site lipid-nanoparticles viral-vector carriers means ‘spikeopathy’ can affect organs. inflammatory properties nanoparticles used ferry mRNA; N1-methylpseudouridine employed prolong synthetic function; biodistribution DNA codes translated spike proteins, autoimmunity via contribute harmful effects. reviews autoimmune, cardiovascular, neurological, potential oncological effects, autopsy spikeopathy. With gene-based therapeutic technologies planned, re-evaluation necessary timely.

Язык: Английский

Процитировано

51

Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle DOI
Hayder M. Al‐kuraishy, Majid S. Jabir,

Ali K. Albuhadily

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102233 - 102233

Опубликована: Фев. 14, 2024

Язык: Английский

Процитировано

17

SIRT1 pathway in Parkinson’s disease: a faraway snapshot but so close DOI Creative Commons
Gaber El‐Saber Batiha, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

Inflammopharmacology, Год журнала: 2022, Номер 31(1), С. 37 - 56

Опубликована: Дек. 29, 2022

Abstract Silent information regulator (SIRT) has distinctive enzymatic activities and physiological functions to control cell-cycle progression, gene expression, DNA stability by targeting histone non-histone proteins. SIRT1 enhances synaptic formation activity, therefore, can reduce the progression of various degenerative brain diseases including Parkinson’s disease (PD). activity is decreased aging with a subsequent increased risk for development diseases. Inhibition promotes inflammatory reactions since inhibits transcription nuclear factor kappa B (NF-κB) which also activation via microRNA miR-34a NAD synthesis. highly expressed in microglia as well neurons, antioxidant anti-inflammatory effects. Therefore, this review aimed find possible role PD neuropathology. neuroprotective effects; downregulation during p53 expression may increase vulnerability neuronal cell deaths. neuropathology linked sequence changes release pro-inflammatory cytokines due signaling pathways. In addition, oxidative stress, disorders, mitochondrial dysfunction, apoptosis contribute mutually Thus, activators play crucial mitigation through amelioration apoptosis,

Язык: Английский

Процитировано

68

Cognitive impairment after long COVID-19: current evidence and perspectives DOI Creative Commons
Zhitao Li, Zhen Zhang, Zhuoya Zhang

и другие.

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Июль 31, 2023

COVID-19, caused by the SARS-CoV-2 virus, is a respiratory infectious disease. While most patients recover after treatment, there growing evidence that COVID-19 may result in cognitive impairment. Recent studies reveal some individuals experience deficits, such as diminished memory and attention, well sleep disturbances, suggesting could have long-term effects on function. Research indicates contribute to decline damaging crucial brain regions, including hippocampus anterior cingulate cortex. Additionally, identified active neuroinflammation, mitochondrial dysfunction, microglial activation patients, implying these factors be potential mechanisms leading Given findings, possibility of impairment following treatment warrants careful consideration. Large-scale follow-up are needed investigate impact function offer support clinical rehabilitation practices. In-depth neuropathological biological can elucidate precise provide theoretical basis for prevention, intervention research. Considering risks reinfection, it imperative integrate basic research data optimize preservation patients' quality life. This integration will also valuable insights responding similar public health events future. perspective article synthesizes discussing outlining future directions.

Язык: Английский

Процитировано

38

DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship DOI
Mohammed Alrouji, Hayder M. Al‐kuraishy,

Ali K. Albuhadily

и другие.

Pharmacological Reports, Год журнала: 2023, Номер 75(4), С. 923 - 936

Опубликована: Июнь 3, 2023

Язык: Английский

Процитировано

22

Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit DOI Creative Commons

Bandar Alharbi,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Март 27, 2024

Abstract Parkinson's disease (PD) is a progressive neurodegenerative as result of the degeneration dopaminergic neurons in substantia nigra pars compacta (SNpc). The fundamental features PD are motor and non-motor symptoms. symptoms develop due to disruption neurotransmitters other such γ-aminobutyric acid (GABA). potential role GABA neuropathology concerning was not precisely discussed. Therefore, this review intended illustrate possible regarding pathway essential regulating inhibitory tone prevent excessive stimulation cerebral cortex. Degeneration linked with reducing GABAergic neurotransmission. Decreasing activity promotes mitochondrial dysfunction oxidative stress, which highly related neuropathology. Hence, restoring by agonists may attenuate progression dysregulation SNpc contributes developing Besides, also pathway, amelioration reduce In conclusion, deregulation might be intricate Improving novel, beneficial approach control

Язык: Английский

Процитировано

14

Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome DOI Creative Commons
Naiara Azcue, Rocío Del Pino, M. Acera

и другие.

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 15, 2023

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID condition can present similarities such as fatigue, brain fog, autonomic neuropathic symptoms.

Язык: Английский

Процитировано

19

Receptor-dependent effects of sphingosine-1-phosphate (S1P) in COVID-19: the black side of the moon DOI Open Access
Hayder M. Al‐kuraishy, Gaber El‐Saber Batiha, Ali I. Al‐Gareeb

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 478(10), С. 2271 - 2279

Опубликована: Янв. 18, 2023

Язык: Английский

Процитировано

14

Role of fenofibrate in multiple sclerosis DOI Creative Commons
Ahmad Abulaban, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Фев. 9, 2024

Abstract Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of central nervous system (CNS). The underlying pathophysiology MS destruction myelin sheath by immune cells. formation plaques, inflammation, injury neuronal characterizes its neuropathology. plaques are multiple focal regions demyelination disseminated in brain's white matter, spinal cords, deep grey cerebral cortex. Fenofibrate a peroxisome proliferative activated receptor alpha (PPAR-α) that attenuates reactions MS. inhibits differentiation Th17 inhibiting expression pro-inflammatory signaling. According to these findings, this review intended illuminate mechanistic immunoinflammatory role fenofibrate mitigating In conclusion, can attenuate neuropathology modulating different pathways, including oxidative stress, autophagy, mitochondrial dysfunction, inflammatory-signaling neuroinflammation.

Язык: Английский

Процитировано

5

Irisin/PGC-1α/FNDC5 pathway in Parkinson’s disease: truth under the throes DOI

Naif H. Ali,

Nourah Alhamdan,

Hayder M. Al‐kuraishy

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(4), С. 1985 - 1995

Опубликована: Окт. 11, 2023

Язык: Английский

Процитировано

12