IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 13, 2024
Quercetin,
a
naturally
occurring
flavonoid,
has
gained
significant
attention
in
recent
years
due
to
its
potential
health
benefits
and
versatile
applications.
This
book
chapter
explores
the
chemistry
of
quercetin,
shedding
light
on
molecular
structure,
biosynthesis,
extraction
methods.
The
delves
into
extensive
research
effects
highlighting
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective,
cardioprotective
properties.
Moreover,
risks
toxicity
associated
with
quercetin
consumption
are
thoroughly
examined,
emphasizing
importance
proper
dosage
drug
interactions.
concludes
by
providing
an
overview
advances
development,
including
nanoformulations,
targeted
delivery
systems,
combination
therapies,
that
hold
promise
for
enhancing
therapeutic
efficacy
bioavailability.
comprehensive
exploration
aims
provide
researchers,
scientists,
healthcare
professionals
valuable
insights
multifaceted
nature
applications
human
health.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 6701 - 6720
Опубликована: Май 1, 2025
Quercetin,
a
prevalent
flavonol
compound,
has
gained
attention
for
its
multifaceted
mechanisms
of
action
against
various
cancers,
highlighting
potential
as
an
adjunctive
therapy
in
cancer
treatments.
This
review
aims
to
systematically
evaluate
the
structural
optimization,
action,
and
clinical
applications
quercetin
nano-derivatives
treatment.
Employing
bibliometric
analysis
6231
articles
from
Web
Science
Core
Collection,
we
observed
notable
increase
annual
publications,
particularly
USA
China,
indicating
growing
interest
quercetin's
therapeutic
potential.
Our
findings
reveal
that
enhances
efficacy
conventional
therapies
by
modulating
critical
signaling
pathways,
thereby
increasing
cell
sensitivity
while
simultaneously
protecting
normal
tissues
therapy-induced
damage.
Structural
modifications,
including
glycosylation,
methylation,
sulfation,
glucuronidation,
alongside
nanoparticle
formulation,
significantly
improve
stability,
solubility,
bioavailability
quercetin,
enabling
targeted
drug
delivery.
Despite
promising
preclinical
outcomes,
translation
remains
nascent,
necessitating
further
rigorous
research
validate
safety
human
subjects.
In
conclusion,
exhibits
substantial
anticancer
properties
potential,
future
studies
should
focus
on
expanding
sample
sizes,
elucidating
metabolic
conducting
comprehensive
trials
inform
application
oncology.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 13, 2024
Quercetin,
a
naturally
occurring
flavonoid,
has
gained
significant
attention
in
recent
years
due
to
its
potential
health
benefits
and
versatile
applications.
This
book
chapter
explores
the
chemistry
of
quercetin,
shedding
light
on
molecular
structure,
biosynthesis,
extraction
methods.
The
delves
into
extensive
research
effects
highlighting
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective,
cardioprotective
properties.
Moreover,
risks
toxicity
associated
with
quercetin
consumption
are
thoroughly
examined,
emphasizing
importance
proper
dosage
drug
interactions.
concludes
by
providing
an
overview
advances
development,
including
nanoformulations,
targeted
delivery
systems,
combination
therapies,
that
hold
promise
for
enhancing
therapeutic
efficacy
bioavailability.
comprehensive
exploration
aims
provide
researchers,
scientists,
healthcare
professionals
valuable
insights
multifaceted
nature
applications
human
health.
