Influence of Vitamin D and Its Analogues in Type-B Lymphomas
Current Oncology,
Год журнала:
2025,
Номер
32(3), С. 135 - 135
Опубликована: Фев. 26, 2025
Lymphomas
represent
a
heterogeneous
group
of
blood
tumors,
generally
divided
into
non-Hodgkin
lymphoma
(NHL)
(90%
all
lymphomas)
and
Hodgkin
(HL).
High-grade
NHL
can
rapidly
progress
so
that
new
strategies
potentially
therapeutical
options
are
needed.
Recently,
it
was
shown
Vitamin
D
(VitD)
inhibits
the
growth
cancer
cells,
controls
their
invasion
metastasis,
strengthens
antitumor
activity
various
types
chemotherapeutic
anticancer
agents.
Therefore,
we
reviewed
recent
literature
about
influence
VitD
its
analogues
(VDAs)
on
treatment
prognosis
B-cell
lymphomas.
As
to
in
vitro
studies
different
cell
lines,
VitD3
VDAs
enhanced
anti-proliferative
efficacy
chemotherapeutics
increased
expression
receptor.
In
vivo
studies,
levels
were
considered:
higher
values
plasma
bioavailable
correlated
with
better
progression-free
survival
(PFS)
overall
(OS),
while
an
unfavorable
PFS
OS
observed
deficient
groups.
No
clinical
trial
made
analogs,
thus
confirming
absence
positive
role
these
synthetic
drugs.
conclusion,
circulating
related
improved
OS,
reduced
cancer-specific
mortality,
disease-free
survival.
analogs
showed
also
effects
only
able
improve
parameters.
Furthermore,
complex
approach
plant-based
diet,
adequate
for
motor
exercise,
and/or
eventual
supplementation
could
be
valuable
strategy
challenge
Язык: Английский
Investigating Vitamin D3’s anticancer mechanisms in MCF-7 cells: a network pharmacology and omics technology approach
Molecular Diversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Язык: Английский
Vitamin D and Ceramide Metabolomic Profile in Acute Myocardial Infarction
Metabolites,
Год журнала:
2024,
Номер
14(4), С. 233 - 233
Опубликована: Апрель 18, 2024
Sphingolipids
(SLs)
influence
several
cellular
pathways,
while
vitamin
D
exerts
many
extraskeletal
effects
in
addition
to
its
traditional
biological
functions,
including
the
modulation
of
calcium
homeostasis
and
bone
health.
Moreover,
Vitamin
SLs
affect
regulation
each
others'
metabolism;
hence,
this
study
aims
evaluate
relationship
between
levels
25(OH)D
ceramides
acute
myocardial
infarction
(AMI).
In
particular,
blood
abundance
eight
was
evaluated
134
AMI
patients
(aged
68.4
±
12.0
years,
72%
males).
A
significant
inverse
correlation
both
Cer(d18:1/16:0)
Cer(d18:1/18:0)
found;
indeed,
with
severe
hypovitaminosis
(<10
ng/mL)
showed
highest
two
investigated
ceramides.
diabetic/dyslipidemic
suboptimal
(<30
had
higher
when
compared
rest
population.
On
other
hand,
remained
an
independent
determinant
for
(STD
Coeff
-0.18,
Язык: Английский