Influence of Vitamin D and Its Analogues in Type-B Lymphomas

Current Oncology, Journal Year: 2025, Volume and Issue: 32(3), P. 135 - 135

Published: Feb. 26, 2025

Lymphomas represent a heterogeneous group of blood tumors, generally divided into non-Hodgkin lymphoma (NHL) (90% all lymphomas) and Hodgkin (HL). High-grade NHL can rapidly progress so that new strategies potentially therapeutical options are needed. Recently, it was shown Vitamin D (VitD) inhibits the growth cancer cells, controls their invasion metastasis, strengthens antitumor activity various types chemotherapeutic anticancer agents. Therefore, we reviewed recent literature about influence VitD its analogues (VDAs) on treatment prognosis B-cell lymphomas. As to in vitro studies different cell lines, VitD3 VDAs enhanced anti-proliferative efficacy chemotherapeutics increased expression receptor. In vivo studies, levels were considered: higher values plasma bioavailable correlated with better progression-free survival (PFS) overall (OS), while an unfavorable PFS OS observed deficient groups. No clinical trial made analogs, thus confirming absence positive role these synthetic drugs. conclusion, circulating related improved OS, reduced cancer-specific mortality, disease-free survival. analogs showed also effects only able improve parameters. Furthermore, complex approach plant-based diet, adequate for motor exercise, and/or eventual supplementation could be valuable strategy challenge

Language: Английский

Investigating Vitamin D3’s anticancer mechanisms in MCF-7 cells: a network pharmacology and omics technology approach

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Vitamin D and Ceramide Metabolomic Profile in Acute Myocardial Infarction

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 233 - 233

Published: April 18, 2024

Sphingolipids (SLs) influence several cellular pathways, while vitamin D exerts many extraskeletal effects in addition to its traditional biological functions, including the modulation of calcium homeostasis and bone health. Moreover, Vitamin SLs affect regulation each others' metabolism; hence, this study aims evaluate relationship between levels 25(OH)D ceramides acute myocardial infarction (AMI). In particular, blood abundance eight was evaluated 134 AMI patients (aged 68.4 ± 12.0 years, 72% males). A significant inverse correlation both Cer(d18:1/16:0) Cer(d18:1/18:0) found; indeed, with severe hypovitaminosis (<10 ng/mL) showed highest two investigated ceramides. diabetic/dyslipidemic suboptimal (<30 had higher when compared rest population. On other hand, remained an independent determinant for (STD Coeff -0.18,

Language: Английский