Experimental Eye Research, Год журнала: 2024, Номер unknown, С. 110096 - 110096
Опубликована: Сен. 1, 2024
Язык: Английский
Critical Care, Год журнала: 2024, Номер 28(1)
Опубликована: Сен. 3, 2024
Sepsis is a severe medical condition characterized by systemic inflammatory response, often culminating in multiple organ dysfunction and high mortality rates. In recent years, there has been growing recognition of the pivotal role played mitochondrial damage driving progression sepsis. Various factors contribute to impairment during sepsis, encompassing mechanisms such as reactive nitrogen/oxygen species generation, mitophagy inhibition, dynamics change, membrane permeabilization. Damaged mitochondria actively participate shaping milieu triggering key signaling pathways, including those mediated Toll-like receptors, NOD-like cyclic GMP-AMP synthase. Consequently, surge interest developing therapeutic strategies targeting mitigate septic pathogenesis. This review aims delve into intricate underpinning sepsis its significant impact on immune dysregulation. Moreover, we spotlight promising mitochondria-targeted interventions that have demonstrated efficacy preclinical models.
Язык: Английский
Процитировано
15
Phytomedicine, Год журнала: 2025, Номер unknown, С. 156664 - 156664
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114671 - 114671
Опубликована: Апрель 19, 2025
Язык: Английский
Процитировано
0
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 29, 2025
Urolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory antioxidative effects. However, the ability metabolize Uros varies among individuals. This Review provides comprehensive insight into synthesis, encapsulation Uros, focusing on biotransformation in vivo. We highlight critical role microbiota urolithins, including primary bacterial species Gordonibacter urolithinfaciens, Enterocloster bolteae Enterococcus faecium. Furthermore, therapeutic potential alleviating neurodegenerative diseases, cancer, Duchenne muscular dystrophy is discussed. Finally, several strategies for enhancing solubility bioavailability are summarized. Future research direction includes identifying key genes involved biotransformation, elucidating bioactive mechanisms improving bioavailability. In conclusion, we synthesized biosynthetic pathways properties better utilization management.
Язык: Английский
Процитировано
0
ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(11), С. 3540 - 3558
Опубликована: Окт. 15, 2024
Urolithin A (UA) has demonstrated the ability to stimulate mitophagy and enhance mitochondrial cellular health in skeletal muscles humans after oral administration. It is hypothesized that targeted delivery of UA as inhaled dry powders lungs will through biogenesis. This study aimed engineer inhalable excipient-free powder inhalers (DPIs) for pulmonary delivery. The particles were designed by particle engineering from dilute organic solutions using state-of-the-art spray drying technology a closed mode. Comprehensive physicochemical characterization advanced microscopy techniques conducted examine phase behavior, molecular properties, which are necessary rational design inhalation aerosols. Molecular fingerprinting was attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy Raman spectroscopy. Chemical imaging mapping confocal (CRM) IR microscopy. spray-dried (SD) successfully produced at different spraying pump feed rates exhibited favorable properties. SD outstanding vitro aerosol dispersion performance with an FDI-approved human DPI device (Neohaler) correlated rate. In
Язык: Английский
Процитировано
2
Experimental Eye Research, Год журнала: 2024, Номер unknown, С. 110096 - 110096
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1