NLRP3 targets HMGB1 to exacerbate the pyroptosis of canine corneal epithelial cells infected with Staphylococcus pseudintermedius DOI
Zhihao Wang, Long Guo, Chengcheng Zhu

et al.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 110096 - 110096

Published: Sept. 1, 2024

Language: Английский

Mitochondrial dysfunction in sepsis: mechanisms and therapeutic perspectives DOI Creative Commons
Dongxue Hu,

Harshini Sheeja Prabhakaran,

Liang Yu

et al.

Critical Care, Journal Year: 2024, Volume and Issue: 28(1)

Published: Sept. 3, 2024

Sepsis is a severe medical condition characterized by systemic inflammatory response, often culminating in multiple organ dysfunction and high mortality rates. In recent years, there has been growing recognition of the pivotal role played mitochondrial damage driving progression sepsis. Various factors contribute to impairment during sepsis, encompassing mechanisms such as reactive nitrogen/oxygen species generation, mitophagy inhibition, dynamics change, membrane permeabilization. Damaged mitochondria actively participate shaping milieu triggering key signaling pathways, including those mediated Toll-like receptors, NOD-like cyclic GMP-AMP synthase. Consequently, surge interest developing therapeutic strategies targeting mitigate septic pathogenesis. This review aims delve into intricate underpinning sepsis its significant impact on immune dysregulation. Moreover, we spotlight promising mitochondria-targeted interventions that have demonstrated efficacy preclinical models.

Language: Английский

Citations

14
Targeting neutrophil dysfunction in acute lung injury: insights from active components of Chinese medicine DOI

Saiya Ye,

Lin Ma, Yayun Chi

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156664 - 156664

Published: March 1, 2025

Language: Английский

Citations

0
Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy DOI
Anqi Zhang,

Shilan Luo,

Jing Li

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114671 - 114671

Published: April 19, 2025

Language: Английский

Citations

0
Appeal of Urolithins from Synthesis to Biological Activities DOI
Hua Xu,

Danyu Lv,

Yongguang Guan

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Urolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory antioxidative effects. However, the ability metabolize Uros varies among individuals. This Review provides comprehensive insight into synthesis, encapsulation Uros, focusing on biotransformation in vivo. We highlight critical role microbiota urolithins, including primary bacterial species Gordonibacter urolithinfaciens, Enterocloster bolteae Enterococcus faecium. Furthermore, therapeutic potential alleviating neurodegenerative diseases, cancer, Duchenne muscular dystrophy is discussed. Finally, several strategies for enhancing solubility bioavailability are summarized. Future research direction includes identifying key genes involved biotransformation, elucidating bioactive mechanisms improving bioavailability. In conclusion, we synthesized biosynthetic pathways properties better utilization management.

Language: Английский

Citations

0
Advanced Spray-Dried Inhalable Microparticles/Nanoparticles of an Innovative Mitophagy Activator for Targeted Lung Delivery: Design, Comprehensive Characterization, Human Lung Cell Culture, and In Vitro Aerosol Dispersion Performance DOI Creative Commons
Hasham S. Sofi,

Andrea J. Lora,

Haley M. Donow

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(11), P. 3540 - 3558

Published: Oct. 15, 2024

Urolithin A (UA) has demonstrated the ability to stimulate mitophagy and enhance mitochondrial cellular health in skeletal muscles humans after oral administration. It is hypothesized that targeted delivery of UA as inhaled dry powders lungs will through biogenesis. This study aimed engineer inhalable excipient-free powder inhalers (DPIs) for pulmonary delivery. The particles were designed by particle engineering from dilute organic solutions using state-of-the-art spray drying technology a closed mode. Comprehensive physicochemical characterization advanced microscopy techniques conducted examine phase behavior, molecular properties, which are necessary rational design inhalation aerosols. Molecular fingerprinting was attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy Raman spectroscopy. Chemical imaging mapping confocal (CRM) IR microscopy. spray-dried (SD) successfully produced at different spraying pump feed rates exhibited favorable properties. SD outstanding vitro aerosol dispersion performance with an FDI-approved human DPI device (Neohaler) correlated rate. In

Language: Английский

Citations

2
NLRP3 targets HMGB1 to exacerbate the pyroptosis of canine corneal epithelial cells infected with Staphylococcus pseudintermedius DOI
Zhihao Wang, Long Guo, Chengcheng Zhu

et al.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 110096 - 110096

Published: Sept. 1, 2024

Language: Английский

Citations

1