Bergapten Ameliorates Psoriatic Skin Lesions and IL‐17A‐Induced Activation of the NF‐κB Signaling Pathway via the Downregulation of CYP1B1 DOI
S. J. Zhu,

Linyan Cheng,

Teng Chen

и другие.

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

ABSTRACT Bergapten (BP) is a plant‐derived furocoumarin that has wide range of pharmacological effects. BP serves as candidate amplifier in phototherapy against skin inflammation, such psoriasis and atopic dermatitis. However, the anti‐inflammatory role remains elusive. We utilized IL‐17A‐stimulated keratinocyte line imiquimod‐challenged BALB/c mice to imitate psoriasis‐like inflammation. Inflammatory phenotypes were determined by expressions inflammatory genes cytokines, histopathological changes activities nuclear factor‐κB (NF‐κB) pathway. An RNA‐seq analysis rodent was performed explore possible mechanism lying behind. SiRNAs antagonist (TMS) cytochrome P450 family 1 subfamily B member (CYP1B1) subsequently used determine CYP1B1 pathogenesis vitro vivo. Overexpression with lentivirus further validate therapeutic effect BP. significantly suppressed activation NF‐κB pathway inhibiting p65 phosphorylation improved phenotype both revealed key regulating signaling Knock‐down siRNAs reduce expression cytokines. intraperitoneal injection TMS partially remediated IMQ‐induced mainly terms thickness. Cyp1b1 led increased protein rescued vitro. This study keratinocytes inhibited blocking p65.

Язык: Английский

Betulinic acid mitigates lipopolysaccharide-induced intestinal injury of weaned piglets through modulation of the mitochondrial quality control DOI

Jiayu He,

Chunlin Huang, Li Kong

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114097 - 114097

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

0
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure DOI Creative Commons
Huan Wu, Long‐Jun Wu, Ligang Luo

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113444 - 113444

Опубликована: Окт. 25, 2024

Язык: Английский

Процитировано

1
Bergapten Ameliorates Psoriatic Skin Lesions and IL‐17A‐Induced Activation of the NF‐κB Signaling Pathway via the Downregulation of CYP1B1 DOI
S. J. Zhu,

Linyan Cheng,

Teng Chen

и другие.

Phytotherapy Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

ABSTRACT Bergapten (BP) is a plant‐derived furocoumarin that has wide range of pharmacological effects. BP serves as candidate amplifier in phototherapy against skin inflammation, such psoriasis and atopic dermatitis. However, the anti‐inflammatory role remains elusive. We utilized IL‐17A‐stimulated keratinocyte line imiquimod‐challenged BALB/c mice to imitate psoriasis‐like inflammation. Inflammatory phenotypes were determined by expressions inflammatory genes cytokines, histopathological changes activities nuclear factor‐κB (NF‐κB) pathway. An RNA‐seq analysis rodent was performed explore possible mechanism lying behind. SiRNAs antagonist (TMS) cytochrome P450 family 1 subfamily B member (CYP1B1) subsequently used determine CYP1B1 pathogenesis vitro vivo. Overexpression with lentivirus further validate therapeutic effect BP. significantly suppressed activation NF‐κB pathway inhibiting p65 phosphorylation improved phenotype both revealed key regulating signaling Knock‐down siRNAs reduce expression cytokines. intraperitoneal injection TMS partially remediated IMQ‐induced mainly terms thickness. Cyp1b1 led increased protein rescued vitro. This study keratinocytes inhibited blocking p65.

Язык: Английский

Процитировано

1