Bergapten Ameliorates Psoriatic Skin Lesions and IL‐17A‐Induced Activation of the NF‐κB Signaling Pathway via the Downregulation of CYP1B1 DOI
S. J. Zhu,

Linyan Cheng,

Teng Chen

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

ABSTRACT Bergapten (BP) is a plant‐derived furocoumarin that has wide range of pharmacological effects. BP serves as candidate amplifier in phototherapy against skin inflammation, such psoriasis and atopic dermatitis. However, the anti‐inflammatory role remains elusive. We utilized IL‐17A‐stimulated keratinocyte line imiquimod‐challenged BALB/c mice to imitate psoriasis‐like inflammation. Inflammatory phenotypes were determined by expressions inflammatory genes cytokines, histopathological changes activities nuclear factor‐κB (NF‐κB) pathway. An RNA‐seq analysis rodent was performed explore possible mechanism lying behind. SiRNAs antagonist (TMS) cytochrome P450 family 1 subfamily B member (CYP1B1) subsequently used determine CYP1B1 pathogenesis vitro vivo. Overexpression with lentivirus further validate therapeutic effect BP. significantly suppressed activation NF‐κB pathway inhibiting p65 phosphorylation improved phenotype both revealed key regulating signaling Knock‐down siRNAs reduce expression cytokines. intraperitoneal injection TMS partially remediated IMQ‐induced mainly terms thickness. Cyp1b1 led increased protein rescued vitro. This study keratinocytes inhibited blocking p65.

Language: Английский

Betulinic acid mitigates lipopolysaccharide-induced intestinal injury of weaned piglets through modulation of the mitochondrial quality control DOI

Jiayu He,

Chunlin Huang, Li Kong

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114097 - 114097

Published: Jan. 18, 2025

Language: Английский

Citations

0
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure DOI Creative Commons
Huan Wu, Long‐Jun Wu, Ligang Luo

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113444 - 113444

Published: Oct. 25, 2024

Language: Английский

Citations

1
Bergapten Ameliorates Psoriatic Skin Lesions and IL‐17A‐Induced Activation of the NF‐κB Signaling Pathway via the Downregulation of CYP1B1 DOI
S. J. Zhu,

Linyan Cheng,

Teng Chen

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

ABSTRACT Bergapten (BP) is a plant‐derived furocoumarin that has wide range of pharmacological effects. BP serves as candidate amplifier in phototherapy against skin inflammation, such psoriasis and atopic dermatitis. However, the anti‐inflammatory role remains elusive. We utilized IL‐17A‐stimulated keratinocyte line imiquimod‐challenged BALB/c mice to imitate psoriasis‐like inflammation. Inflammatory phenotypes were determined by expressions inflammatory genes cytokines, histopathological changes activities nuclear factor‐κB (NF‐κB) pathway. An RNA‐seq analysis rodent was performed explore possible mechanism lying behind. SiRNAs antagonist (TMS) cytochrome P450 family 1 subfamily B member (CYP1B1) subsequently used determine CYP1B1 pathogenesis vitro vivo. Overexpression with lentivirus further validate therapeutic effect BP. significantly suppressed activation NF‐κB pathway inhibiting p65 phosphorylation improved phenotype both revealed key regulating signaling Knock‐down siRNAs reduce expression cytokines. intraperitoneal injection TMS partially remediated IMQ‐induced mainly terms thickness. Cyp1b1 led increased protein rescued vitro. This study keratinocytes inhibited blocking p65.

Language: Английский

Citations

1