Journal of Functional Foods, Год журнала: 2024, Номер 124, С. 106643 - 106643
Опубликована: Дек. 22, 2024
Язык: Английский
Expert Opinion on Drug Delivery, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, antiviral properties, particularly in vitro or silico; however, their vivo applications are hindered by inadequate absorption distribution the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) nanostructured carriers (NLC) has significant advancements represents a viable approach to improve bioavailability through different administration routes.
Язык: Английский
Процитировано
3
Journal of Herbal Medicine, Год журнала: 2025, Номер unknown, С. 100998 - 100998
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
IOP Conference Series Earth and Environmental Science, Год журнала: 2025, Номер 1449(1), С. 012159 - 012159
Опубликована: Фев. 1, 2025
Abstract The objective of the current investigation was to investigate effects two natural substances, omega-3 and Silymarin, on body-weight glucose levels in diabetic rats. This attempted examine benefits silymarin blood sugar rats, as well ability each therapy enhance medical condition patients. Study results indicated that rats did not get lost considerable weight owing insulin lacking causing their bodies use both muscle fat substitutes for energy. whereas, supplied with gained weight, since encouraged development, whereas enabled strengthening plasma membranes thereby avoiding depletion. substances significantly reduced levels, confirming significance enhancing glycemic control, reducing inflammation, regulating metabolic processes. Silymarin is demonstrated be better lowering than Omega-3.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2025, Номер unknown, С. 156717 - 156717
Опубликована: Апрель 1, 2025
Diabetes mellitus (DM) is a chronic metabolic disease with high global prevalence. Lignans, class of plant natural compounds found in commonly consumed foods, are well-tolerated by humans and have demonstrated promising potential the management DM. Consumption lignan-rich foods has been associated improved overall health quality life. The clinical preclinical evidence on role lignans managing DM critically examined. A thorough literature search was conducted across major scientific databases, focusing studies that reported effects individual key diabetes indicators, such as glucose utilisation insulin sensitivity, both human animal models, well cell-based studies. total 180 were included review. Out these, only three investigated randomised trials 31 models. reviewed suggests some beneficial preventing development obesity-related diabetes. Their therapeutic benefits diabetes-related complications, particularly diabetic nephropathy, type 1 2 diabetes, also supported. Metabolites various lignans, produced microbial metabolism gut serum enzymes, appear to be bioactive forms, highlighting need for detailed pharmacodynamic studies, optimised dosage designs, use appropriate lignan molecules screening. Lignans their metabolites show promise mitigating complications though further needed optimize potential.
Язык: Английский
Процитировано
0
Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер 769, С. 110433 - 110433
Опубликована: Апрель 21, 2025
Язык: Английский
Процитировано
0
Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111913 - 111913
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Medicina, Год журнала: 2024, Номер 60(6), С. 999 - 999
Опубликована: Июнь 18, 2024
Background and Objectives: Coadministration of natural products to enhance the potency conventional antirheumatic treatment is high interest. This study aimed assess impact administration silymarin (a nutritional supplement) in patients with active rheumatoid arthritis under disease-modifying drugs. Materials Methods: One-hundred twenty-two diagnosed treated drugs were randomly assigned either control or intervention groups; latter was supplemented (300 mg/day) for 8 weeks. Indicators disease activity, inflammatory markers, activity disability indices, European League Against Rheumatism responses, fatigue, depression, anxiety scores determined at baseline week 8. Results: Silymarin supplementation significantly reduced number tender swollen joints, duration morning stiffness, severity pain, levels anxiety. According our results, substantially improved patients’ general condition. Conclusions: Our provides evidence benefits arthritis.
Язык: Английский
Процитировано
2
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(12), С. 9345 - 9366
Опубликована: Июль 9, 2024
Язык: Английский
Процитировано
2
Cells, Год журнала: 2024, Номер 13(14), С. 1186 - 1186
Опубликована: Июль 12, 2024
Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance cytoplasmic quality control, addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes deaths globally shows resistance several anticancer drugs. Despite rising incidence poor prognosis malignant HCC, underlying molecular mechanisms driving this aggressive remain unclear. Several natural compounds, phytochemicals dietary non-dietary origin, affect hepatocarcinogenesis signaling pathways vitro vivo, which may help prevent treat HCC cells. Current cells treatments include chemotherapy, radiation, surgery. However, these standard therapies have substantial side effects, combination therapy enhances effects for acceptable therapeutic benefit. Therefore, there need develop treatment strategies are more efficacious fewer adverse effects. Multiple genetic epigenetic factors responsible become resistant treatment. Autophagy contributes maintain homeostasis, activates autophagy biosynthesis mitochondrial regulation recycling. modifying autophagic would present promising opportunity identify novel current treatments. This comprehensive review illustrates how compounds demonstrate their anti-hepatocellular through autophagy.
Язык: Английский
Процитировано
2
Journal of Functional Foods, Год журнала: 2024, Номер 124, С. 106643 - 106643
Опубликована: Дек. 22, 2024
Язык: Английский
Процитировано
1