
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106643 - 106643
Published: Dec. 22, 2024
Language: Английский
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106643 - 106643
Published: Dec. 22, 2024
Language: Английский
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 769, P. 110433 - 110433
Published: April 21, 2025
Language: Английский
Citations
0Journal of Herbal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100998 - 100998
Published: Feb. 1, 2025
Language: Английский
Citations
0IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1449(1), P. 012159 - 012159
Published: Feb. 1, 2025
Abstract The objective of the current investigation was to investigate effects two natural substances, omega-3 and Silymarin, on body-weight glucose levels in diabetic rats. This attempted examine benefits silymarin blood sugar rats, as well ability each therapy enhance medical condition patients. Study results indicated that rats did not get lost considerable weight owing insulin lacking causing their bodies use both muscle fat substitutes for energy. whereas, supplied with gained weight, since encouraged development, whereas enabled strengthening plasma membranes thereby avoiding depletion. substances significantly reduced levels, confirming significance enhancing glycemic control, reducing inflammation, regulating metabolic processes. Silymarin is demonstrated be better lowering than Omega-3.
Language: Английский
Citations
0Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156717 - 156717
Published: April 1, 2025
Diabetes mellitus (DM) is a chronic metabolic disease with high global prevalence. Lignans, class of plant natural compounds found in commonly consumed foods, are well-tolerated by humans and have demonstrated promising potential the management DM. Consumption lignan-rich foods has been associated improved overall health quality life. The clinical preclinical evidence on role lignans managing DM critically examined. A thorough literature search was conducted across major scientific databases, focusing studies that reported effects individual key diabetes indicators, such as glucose utilisation insulin sensitivity, both human animal models, well cell-based studies. total 180 were included review. Out these, only three investigated randomised trials 31 models. reviewed suggests some beneficial preventing development obesity-related diabetes. Their therapeutic benefits diabetes-related complications, particularly diabetic nephropathy, type 1 2 diabetes, also supported. Metabolites various lignans, produced microbial metabolism gut serum enzymes, appear to be bioactive forms, highlighting need for detailed pharmacodynamic studies, optimised dosage designs, use appropriate lignan molecules screening. Lignans their metabolites show promise mitigating complications though further needed optimize potential.
Language: Английский
Citations
0Medicina, Journal Year: 2024, Volume and Issue: 60(6), P. 999 - 999
Published: June 18, 2024
Background and Objectives: Coadministration of natural products to enhance the potency conventional antirheumatic treatment is high interest. This study aimed assess impact administration silymarin (a nutritional supplement) in patients with active rheumatoid arthritis under disease-modifying drugs. Materials Methods: One-hundred twenty-two diagnosed treated drugs were randomly assigned either control or intervention groups; latter was supplemented (300 mg/day) for 8 weeks. Indicators disease activity, inflammatory markers, activity disability indices, European League Against Rheumatism responses, fatigue, depression, anxiety scores determined at baseline week 8. Results: Silymarin supplementation significantly reduced number tender swollen joints, duration morning stiffness, severity pain, levels anxiety. According our results, substantially improved patients’ general condition. Conclusions: Our provides evidence benefits arthritis.
Language: Английский
Citations
2Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9345 - 9366
Published: July 9, 2024
Language: Английский
Citations
2Cells, Journal Year: 2024, Volume and Issue: 13(14), P. 1186 - 1186
Published: July 12, 2024
Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance cytoplasmic quality control, addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes deaths globally shows resistance several anticancer drugs. Despite rising incidence poor prognosis malignant HCC, underlying molecular mechanisms driving this aggressive remain unclear. Several natural compounds, phytochemicals dietary non-dietary origin, affect hepatocarcinogenesis signaling pathways vitro vivo, which may help prevent treat HCC cells. Current cells treatments include chemotherapy, radiation, surgery. However, these standard therapies have substantial side effects, combination therapy enhances effects for acceptable therapeutic benefit. Therefore, there need develop treatment strategies are more efficacious fewer adverse effects. Multiple genetic epigenetic factors responsible become resistant treatment. Autophagy contributes maintain homeostasis, activates autophagy biosynthesis mitochondrial regulation recycling. modifying autophagic would present promising opportunity identify novel current treatments. This comprehensive review illustrates how compounds demonstrate their anti-hepatocellular through autophagy.
Language: Английский
Citations
2Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, antiviral properties, particularly in vitro or silico; however, their vivo applications are hindered by inadequate absorption distribution the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) nanostructured carriers (NLC) has significant advancements represents a viable approach to improve bioavailability through different administration routes.
Language: Английский
Citations
1Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106643 - 106643
Published: Dec. 22, 2024
Language: Английский
Citations
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