Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications DOI Creative Commons

Soroush Fotouhi,

Aida Yavari,

Amir Bagheri

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106643 - 106643

Published: Dec. 22, 2024

Language: Английский

AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions DOI

Xianshi Wang,

Xueying Sun, Xiaodi Zhang

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 769, P. 110433 - 110433

Published: April 21, 2025

Language: Английский

Citations

0

Efficacy of Traditional Chinese Medicine combined with Conventional Western Medicine on Metabolic Syndrome: A Bayesian Network Meta-Analysis DOI
Yanmin Zhang, Yixuan Fang, Nannan Xing

et al.

Journal of Herbal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100998 - 100998

Published: Feb. 1, 2025

Language: Английский

Citations

0

The Effectiveness of Therapeutic Feeding with Omega-3 and Silymarin on Male Rats with Induced Diabetes DOI Open Access

Manaa Jamel,

Adnan Mustafa

IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1449(1), P. 012159 - 012159

Published: Feb. 1, 2025

Abstract The objective of the current investigation was to investigate effects two natural substances, omega-3 and Silymarin, on body-weight glucose levels in diabetic rats. This attempted examine benefits silymarin blood sugar rats, as well ability each therapy enhance medical condition patients. Study results indicated that rats did not get lost considerable weight owing insulin lacking causing their bodies use both muscle fat substitutes for energy. whereas, supplied with gained weight, since encouraged development, whereas enabled strengthening plasma membranes thereby avoiding depletion. substances significantly reduced levels, confirming significance enhancing glycemic control, reducing inflammation, regulating metabolic processes. Silymarin is demonstrated be better lowering than Omega-3.

Language: Английский

Citations

0

The antidiabetic properties of lignans: a comprehensive review DOI Creative Commons
Murtala Bindawa Isah, Nasir Tajuddeen, Anas Yusuf

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156717 - 156717

Published: April 1, 2025

Diabetes mellitus (DM) is a chronic metabolic disease with high global prevalence. Lignans, class of plant natural compounds found in commonly consumed foods, are well-tolerated by humans and have demonstrated promising potential the management DM. Consumption lignan-rich foods has been associated improved overall health quality life. The clinical preclinical evidence on role lignans managing DM critically examined. A thorough literature search was conducted across major scientific databases, focusing studies that reported effects individual key diabetes indicators, such as glucose utilisation insulin sensitivity, both human animal models, well cell-based studies. total 180 were included review. Out these, only three investigated randomised trials 31 models. reviewed suggests some beneficial preventing development obesity-related diabetes. Their therapeutic benefits diabetes-related complications, particularly diabetic nephropathy, type 1 2 diabetes, also supported. Metabolites various lignans, produced microbial metabolism gut serum enzymes, appear to be bioactive forms, highlighting need for detailed pharmacodynamic studies, optimised dosage designs, use appropriate lignan molecules screening. Lignans their metabolites show promise mitigating complications though further needed optimize potential.

Language: Английский

Citations

0

Silymarin Supplementation in Active Rheumatoid Arthritis: Outcomes of a Pilot Randomized Controlled Clinical Study DOI Creative Commons

G. Zugravu,

Carmen Pintilescu,

Carmen Marinela Cumpăt

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(6), P. 999 - 999

Published: June 18, 2024

Background and Objectives: Coadministration of natural products to enhance the potency conventional antirheumatic treatment is high interest. This study aimed assess impact administration silymarin (a nutritional supplement) in patients with active rheumatoid arthritis under disease-modifying drugs. Materials Methods: One-hundred twenty-two diagnosed treated drugs were randomly assigned either control or intervention groups; latter was supplemented (300 mg/day) for 8 weeks. Indicators disease activity, inflammatory markers, activity disability indices, European League Against Rheumatism responses, fatigue, depression, anxiety scores determined at baseline week 8. Results: Silymarin supplementation significantly reduced number tender swollen joints, duration morning stiffness, severity pain, levels anxiety. According our results, substantially improved patients’ general condition. Conclusions: Our provides evidence benefits arthritis.

Language: Английский

Citations

2

Ellagic acid as potential therapeutic compound for diabetes and its complications: a systematic review from bench to bed DOI
Hossein Ghazaee, Alireza Raouf Sheibani, Haniyeh Mahdian

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9345 - 9366

Published: July 9, 2024

Language: Английский

Citations

2

Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets DOI Creative Commons
Md. Ataur Rahman, S M Rakib-Uz-Zaman, Somdeepa Chakraborti

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(14), P. 1186 - 1186

Published: July 12, 2024

Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance cytoplasmic quality control, addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes deaths globally shows resistance several anticancer drugs. Despite rising incidence poor prognosis malignant HCC, underlying molecular mechanisms driving this aggressive remain unclear. Several natural compounds, phytochemicals dietary non-dietary origin, affect hepatocarcinogenesis signaling pathways vitro vivo, which may help prevent treat HCC cells. Current cells treatments include chemotherapy, radiation, surgery. However, these standard therapies have substantial side effects, combination therapy enhances effects for acceptable therapeutic benefit. Therefore, there need develop treatment strategies are more efficacious fewer adverse effects. Multiple genetic epigenetic factors responsible become resistant treatment. Autophagy contributes maintain homeostasis, activates autophagy biosynthesis mitochondrial regulation recycling. modifying autophagic would present promising opportunity identify novel current treatments. This comprehensive review illustrates how compounds demonstrate their anti-hepatocellular through autophagy.

Language: Английский

Citations

2

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II – applications and preclinical advancements DOI
Faezeh Fathi, Tatiane de Oliveira Xavier Machado,

Helena A. C. Kodel

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Numerous purified bioactive compounds, crude extracts, and essential oils have demonstrated potent antioxidant, antimicrobial, anti-inflammatory, antiviral properties, particularly in vitro or silico; however, their vivo applications are hindered by inadequate absorption distribution the organism. The incorporation of these phytochemicals into solid lipid nanoparticles (SLN) nanostructured carriers (NLC) has significant advancements represents a viable approach to improve bioavailability through different administration routes.

Language: Английский

Citations

1

Exploring the promising impacts of naringin and its aglycone constituent naringenin as major citrus flavonoids on diabetes and its complications DOI Creative Commons

Soroush Fotouhi,

Aida Yavari,

Amir Bagheri

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106643 - 106643

Published: Dec. 22, 2024

Language: Английский

Citations

1