A novel approach to the prevention and management of chemotherapy-induced cardiotoxicity: PANoptosis

Chemico-Biological Interactions, Год журнала: 2025, Номер 407, С. 111379 - 111379

Опубликована: Янв. 8, 2025

Язык: Английский

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Betaine: A Comprehensive Review on Dietary Sources, Health Benefits, Mechanisms of Action, and Application

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104993 - 104993

Опубликована: Апрель 1, 2025

Язык: Английский

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NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: role of phytochemicals

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

Doxorubicin (DOX) has received widespread attention as a broad-spectrum antitumor drug. However, it been recognized challenge that long-term DOX injections can lead to severe cardiotoxicity. There are numerous interventions DOX-induced cardiotoxicity, and the most cost-effective is phytochemicals. It reported phytochemicals have complex diverse biological properties, facilitating mitigation of cardiotoxicity pathological mechanisms, nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis one them. This review initially presents an overview mechanisms underlie induced by DOX. Subsequently, we present comprehensive elucidation structure activation NLRP3 inflammasome. Finally, provide detailed summary mitigate influencing expression inflammasome in cardiomyocytes.

Язык: Английский

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Betaine alleviates methomyl-triggered oxidative stress-mediated cardiopulmonary inflammation in rats through iNOS/Cox2 and Nrf2/HO1/Keap1 signaling pathway

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 495, С. 117223 - 117223

Опубликована: Дек. 31, 2024

Язык: Английский

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