A novel approach to the prevention and management of chemotherapy-induced cardiotoxicity: PANoptosis

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: 407, P. 111379 - 111379

Published: Jan. 8, 2025

Language: Английский

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Betaine: A Comprehensive Review on Dietary Sources, Health Benefits, Mechanisms of Action, and Application

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104993 - 104993

Published: April 1, 2025

Language: Английский

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NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: role of phytochemicals

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Doxorubicin (DOX) has received widespread attention as a broad-spectrum antitumor drug. However, it been recognized challenge that long-term DOX injections can lead to severe cardiotoxicity. There are numerous interventions DOX-induced cardiotoxicity, and the most cost-effective is phytochemicals. It reported phytochemicals have complex diverse biological properties, facilitating mitigation of cardiotoxicity pathological mechanisms, nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-mediated cardiomyocyte pyroptosis one them. This review initially presents an overview mechanisms underlie induced by DOX. Subsequently, we present comprehensive elucidation structure activation NLRP3 inflammasome. Finally, provide detailed summary mitigate influencing expression inflammasome in cardiomyocytes.

Language: Английский

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Betaine alleviates methomyl-triggered oxidative stress-mediated cardiopulmonary inflammation in rats through iNOS/Cox2 and Nrf2/HO1/Keap1 signaling pathway

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 495, P. 117223 - 117223

Published: Dec. 31, 2024

Language: Английский

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