Anti-angiogenic and anti-oxidant effects of 2-NTI indole derivative vs. suramin in ex vivo, in vivo, and in vitro studies

Cytotechnology, Год журнала: 2025, Номер 77(1)

Опубликована: Янв. 7, 2025

Язык: Английский

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Evaluation of common topical therapeutic agents of plane warts

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Янв. 15, 2025

Язык: Английский

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Protective effect of orientin on diabetic nephropathy in rat models of high-fat diet and streptozotocin-induced diabetes

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

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Therapeutic effect of bosentan on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Фев. 18, 2025

Язык: Английский

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Inhibitory effects of carbohydrazide indole derivative on micro-blood vessel growth using ex vivo, in vivo, and in vitro assays

In Vitro Cellular & Developmental Biology - Animal, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

Язык: Английский

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The Possible effect of Bosentan on the methotrexate-induced salivary gland changes in male rats: histological and Immunohistochemical study

Toxicology Research, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 31, 2024

Abstract Methotrexate (MTX) is an antimetabolite drug utilized for managing a variety of cancers and autoinflammatory conditions. MTX may trigger detrimental effects in mout, h tissues, including salivary gland impairment. Bosentan (BOS), that blocks endothelin receptors, has strengthened antioxidant, anti-inflammatory, anti-apoptotic properties. The study aimed to estimate the protective effect BOS on MTX-exacerbated changes Wistar Albino rats. Thirty male rats were arbitrarily sorted into three groups ten animals each. control group received normal saline 18 days. (induction) (25 mg/kg) intraperitoneally 7th day experiment once daily 6 consecutive + (50 orally days: days before induction, 2-h after post-induction. Animals euthanized 19, tissues dissected biochemical, histopathological, immunohistochemical analyses. dramatically improved MTX-aggravated biochemical histopathological abnormalities, as evidenced by diminished Bax, caspase 3, TNF-α, IL-1β, MDA, MPO levels, increased SOD, GSH, GPX reduced degenerative granular convolute tubule, mucous acini, striate duct. further substantially upregulated MTX-induced decline Ki-67 Bcl-2, indicated immunohistochemistry scoring methods. anti-oxidative, ant-inflammatory, antiapoptotic properties are promising strategy ameliorating toxic submandibular glandular tissues.

Язык: Английский

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Modulation of gut propionate and intestinal mucosal protection by Bifidobacterium longum: Mitigating methotrexate side effects without compromising the efficacy of psoriasis therapy

International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114196 - 114196

Опубликована: Фев. 3, 2025

Язык: Английский

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Skin Healing Potential of Bioactive Components From Lycoperdon lividum Mushroom Versus β‐Sitosterol in Rat Model of Burn Wounds

Microscopy Research and Technique, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

ABSTRACT Burn injury elicits an inflammatory response, metabolic abnormalities, and distributional shock leading to diverse organ dysfunctions with remarkable morbidity mortality. Sluggish wound healing, infections, hypertrophic scars still struggle in burn treatment. Lycoperdon lividum , a puffball mushroom enriched polyphenols, has outstanding antioxidative anti‐inflammatory properties. This study aimed assess the benefits of L. on second‐degree lesions rat model at 100°C. Seventy‐five male rats were haphazardly separated into five groups 15 each: Control (without any skin induction/treatment), (skin induction/non‐treated), β‐sitosterol (treated topical 0.25%), Vehicle Vaseline), watery extract 10%). Rats euthanized Days 5, 10, 20 experiment. was analyzed using HPLC techniques. Skin samples collected for microscopical histopathological examinations. Biomarkers involving IL‐6, IL‐10, TGF‐β1, TNF‐α, VEGF homogenates. The chromatogram revealed distinct peaks bioactive compounds including kaempferol, rutin, ferulic acid, caffeic chlorogenic quercetin, gallic acid. greatly alleviated via improving contraction, correcting inflammation, granulation aberrations while boosting fibrosis. outcomes validated by analyses. Further, markedly improved healing wounds regulating cytokines (IL‐6 TNF‐α), (IL‐10 TGF‐β1), angiogenic (VEGF) tissues. potential thanks its antioxidant actions.

Язык: Английский

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A comparative study of the effects of topical dexamethasone 0.1% and loteprednol etabonate 0.5% on clinical ocular parameters in Iraqi patients following cataract surgery

F1000Research, Год журнала: 2025, Номер 14, С. 114 - 114

Опубликована: Янв. 20, 2025

Background Cataracts are an assortment of conditions causing the lens to become opaque and lose its typical transparency. Topical corticosteroids like loteprednol etabonate dexamethasone commonly administered alleviate inflammation following cataract surgery. Aim study To compare efficacy in managing different clinical parameters removal, as well their patient safety. Methods This trial was registered by local IRB at College Medicine/University Baghdad on November 27, 2023, under document approval number UoB.Med.21. Patients undergoing surgery were randomly assigned two groups: group A received 0.5% drop postoperatively for four weeks, while B 0.1% same period. The levels intraocular pressure (IOP), anterior chamber (AC) reaction, scores flare, conjunctival congestion, pain monitored one weeks during follow-up visits. Results visual outcomes similar between groups, both treatments tolerated with minor side effects. Both effectively reduced IOP, AC grading patients. None these measures displayed any significant differences drugs. Conclusion There is no difference topical pertaining ocular post-cataract decision may depend needs preferences.

Язык: Английский

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The role of Juniperus Macrocarpa extract as anti-inflammatory and antioxidant on methotrexate-induced acute liver injury in rat model

F1000Research, Год журнала: 2025, Номер 14, С. 131 - 131

Опубликована: Янв. 27, 2025

Methotrexate (MTX) is an antifolate medication indicated to treat array of tumors and autoinflammatory maladies. MTX may exhibit harmful impacts on multiple organs, especially liver injury cirrhosis. Juniperus macrocarpa a medicinal herb enriched with polyphenols flavonoids featuring robust anti-inflammatory antioxidative benefits. To evaluate the hepatoprotective effects aqueous extract MTX-aggravated toxicity. The study involved 20 male middle-aged albino rats, arbitrarily allocated into 4 groups 5 animals each. Group 1 (control) were given distilled water (DW) once daily for two weeks. 2 got intraperitoneal single dose (20 mg/kg) Rats in 3 dosages 100 mg 200 extract, respectively, weeks before receiving injection. extracts at both low high doses substantially alleviated MTX-provoked biochemical alterations, as evidenced by decreased levels inflammatory parameters including TNF-α IL-6 hepatic enzymes ALT, AST, ALP. also significantly boosted anti-oxidant like SOD GPX. Moreover, attenuated congestive degenerative changes, improved histopathological findings. anti-oxidative activities are promising approach ameliorating hepatotoxicity.

Язык: Английский

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