The microbiota-gut-brain-axis theory: role of gut microbiota modulators (GMMs) in gastrointestinal, neurological, and mental health disorders DOI Creative Commons
Al-Hassan Soliman Wadan, Mostafa K. Abd El‐Aziz, Doha El‐Sayed Ellakwa

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract The modulation of gut microbiota presents promising therapeutic possibilities for various health conditions, ranging from gastrointestinal infections to neurodegenerative and mental disorders. Among the available interventions, modulators (GMMs) such as probiotics prebiotics have demonstrated significant potential in infection prevention neuroprotection. Despite these encouraging findings, clinical application GMMs remains challenging due safety concerns inconsistent effectiveness across diverse patient populations. These factors create substantial barriers widespread adoption microbiota-based therapies practice. To overcome challenges fully leverage modulation, this review explores feasibility repurposing managing multiple A broad spectrum microbiota-targeted strategies is examined, including dietary modifications, fecal transplantation, bacteriophage therapy, microbiome engineering, immune system modulation. particularly innovative approach involves integrating with pharmaceutical delivery systems enhance efficacy while mitigating adverse effects. This integrative strategy underscores pivotal role disease, supporting development precision medicine tailored individual needs. By combining targeted mechanisms, not only improves treatment but also addresses critical regarding variability. Furthermore, outlines future research directions within rapidly evolving field emphasizing necessity comprehensive trials long-term evaluations. critically assessing both opportunities associated study provides a strategic framework translating experimental into viable applications. holistic has redefine paradigms, offering personalized wide range disorders advancing broader medicine.

Язык: Английский

MircoRNAs predict and modulate responses to chemotherapy in leukemic patients DOI
Doha El‐Sayed Ellakwa,

Mohamed Ahmed Abdelmalek,

Mostafa Mostafa

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

7

Tailored therapies for triple-negative breast cancer: current landscape and future perceptions DOI

Yumna Khan,

Sana Rizvi, Ali Raza

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

4

Cerebrolysin in post-TBI recovery: Pharmacology and clinical evidence DOI
Doha El‐Sayed Ellakwa,

Ahmed Mansour,

Rimon Gorgui

и другие.

Gene Reports, Год журнала: 2025, Номер unknown, С. 102202 - 102202

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Response of different infection models in broiler chickens against supplemental Organic acid – A review DOI
Roshan Riaz, İbrar Ahmed, Ali Raza

и другие.

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107527 - 107527

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1

The microbiota-gut-brain-axis theory: role of gut microbiota modulators (GMMs) in gastrointestinal, neurological, and mental health disorders DOI Creative Commons
Al-Hassan Soliman Wadan, Mostafa K. Abd El‐Aziz, Doha El‐Sayed Ellakwa

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract The modulation of gut microbiota presents promising therapeutic possibilities for various health conditions, ranging from gastrointestinal infections to neurodegenerative and mental disorders. Among the available interventions, modulators (GMMs) such as probiotics prebiotics have demonstrated significant potential in infection prevention neuroprotection. Despite these encouraging findings, clinical application GMMs remains challenging due safety concerns inconsistent effectiveness across diverse patient populations. These factors create substantial barriers widespread adoption microbiota-based therapies practice. To overcome challenges fully leverage modulation, this review explores feasibility repurposing managing multiple A broad spectrum microbiota-targeted strategies is examined, including dietary modifications, fecal transplantation, bacteriophage therapy, microbiome engineering, immune system modulation. particularly innovative approach involves integrating with pharmaceutical delivery systems enhance efficacy while mitigating adverse effects. This integrative strategy underscores pivotal role disease, supporting development precision medicine tailored individual needs. By combining targeted mechanisms, not only improves treatment but also addresses critical regarding variability. Furthermore, outlines future research directions within rapidly evolving field emphasizing necessity comprehensive trials long-term evaluations. critically assessing both opportunities associated study provides a strategic framework translating experimental into viable applications. holistic has redefine paradigms, offering personalized wide range disorders advancing broader medicine.

Язык: Английский

Процитировано

1