A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius, Huihui Zhao

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 712 - 712

Опубликована: Май 12, 2025

‘Blood stasis’ (syndrome) (BSS) is a fundamental concept in Traditional Chinese Medicine (TCM), where it known as Xue Yu (血瘀). Similar concepts exist Korean (‘Eohyul’) and Japanese Kampo medicine (Oketsu). Blood stasis considered to underpin large variety of inflammatory diseases, though an exact equivalent Western systems yet be described. Some time ago we discovered that blood can clot into anomalous amyloid form, creating what have referred fibrinaloid microclots. These microclots occur great many chronic, diseases are comparatively resistant fibrinolysis, thus the ability block microcapillaries hence lower oxygen transfer tissues, with multiple pathological consequences. We here develop idea precisely relate to, largely mechanistically responsible for, traditional (a term also used by Virchow). First, associated all stasis. Secondly, blocking red cell transport, provide simple mechanistic explanation for physical slowing down (‘stasis’) flow. Thirdly, herbal formulae proposed treat these especially Fu Zhu its derivatives, anticoagulatory anti-inflammatory, consistent they actually helping levels microclots, plausibly part catalysis polymerization fibrinogen form. rehearse some actions constituent herbs specific bioactive molecules contain. Consequently, such formulations (and their components), which little science medicine, would seem offer opportunity novel, safe, useful treatments chronic display including Myalgic Encephalopathy/Chronic Fatigue Syndrome, long COVID, even ischemic stroke.

Язык: Английский

Unravelling the epigenetic based mechanism in discovery of anticancer phytomedicine: Evidence based studies DOI
Bushra Bashir, Pranshul Sethi,

Satyajit Panda

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111743 - 111743

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Simultaneous Quantification of Phenolic Compounds in the Leaves and Roots of Peucedanum japonicum Thunb. Using HPLC-PDA with Various Extraction Solvents DOI Creative Commons
Neil Patrick Uy,

Sang Yun Lee,

Jang Hoon Kim

и другие.

Horticulturae, Год журнала: 2025, Номер 11(3), С. 334 - 334

Опубликована: Март 19, 2025

This study investigated the extraction and quantification of specific phenolic compounds, including chlorogenic acid several pyranocoumarin derivatives, from leaves roots Peucedanum japonicum. Using high-performance liquid chromatography, this aimed to optimize methodologies with different solvents maximize yield bioactive compounds. The process involved meticulous steps, reflux solvent evaporation, total content was assessed using a spectrophotometric assay. results demonstrated that ethanol methanol were effective in extracting acid, yielding up 47.71 mg/g tannic equivalent MeOH extracts roots. Conversely, acetone superior for extraction, achieving coumarin exceeding 100 root extracts. Notably, pyranocoumarins found be more concentrated compared leaves, supporting hypothesis are reservoir these emphasized critical roles selections profiling compounds P. japonicum provided valuable insights future research into its pharmacological potential. findings may serve as foundation further studies, enhancing understanding medicinal properties context traditional East Asian medicine.

Язык: Английский

Процитировано

0
Machine learning modeling and response surface methodology driven antioxidant and anticancer activities of chitosan nanoparticle-mediated extracts of Bacopa monnieri DOI
Serap Pamak Bulut, Muhammad Aasım, Buğrahan Emsen

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143470 - 143470

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo implications DOI
Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

и другие.

Expert Opinion on Therapeutic Targets, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Squalene epoxidase (SQLE) is a pivotal enzyme in sterol biosynthesis, catalyzing the conversion of squalene to 2,3-oxidosqualene. Beyond its core role cholesterol homeostasis, SQLE implicated cancer, hypercholesterolemia, and fungal infections, positioning it as valuable therapeutic target. We conducted comprehensive literature search across primary databases gather vitro, silico, vivo evidence on SQLE. This review explores enzyme's structural functional features, including substrate specificity catalytic mechanisms, examines inhibitor interactions. Computational methods predict - dynamics, guiding drug design, while investigations clarify SQLE's metabolic disorders tumorigenesis. Challenges include resistance study discrepancies, but emerging technologies, such cryo-electron microscopy CRISPR editing, offer new avenues for deeper exploration. an underexplored yet promising target, with particular relevance oxidative stress, ferroptosis, gut microbiota research. Overcoming current barriers through advanced technologies multidisciplinary strategies could propel SQLE-targeted treatments into clinical practice, supporting precision medicine broader translational applications.

Язык: Английский

Процитировано

0
Synthesis and Biological Screening of Structurally Modified Phaeosphaeride Analogues DOI Creative Commons

Konstantinos Rantzios,

Oraia-Eirini Chatzimentor,

George Leonidis

и другие.

Molecules, Год журнала: 2025, Номер 30(9), С. 2016 - 2016

Опубликована: Апрель 30, 2025

Phaeosphaeride A and its analogues have been extensively explored for their potential pharmacological applications, particularly in the development of anticancer agents. In this study, synthesis structurally modified phaeosphaeride is reported. The structures synthesized bearing tetrahydro- hexahydro-2H-furo[3,2-b]pyran-2-one hexahydropyrano[3,2-b]pyrrol-2(1H)-one moieties were assessed new compounds evaluated antiproliferative activity against two cancer cell lines. Despite successful structural modification, majority exhibited limited bioactivity. Structure-activity relationship studies suggested that specific modifications did not enhance potency. hydroxy groups alkyl moiety cyclic or non-cyclic contribute to activity, as shown by 24 25. presence double bonds oxygen nitrogen heteroatoms furopyranones pyranopyrrolones 9, 28, 29 33a, does significantly impact cytotoxic activity. These findings highlight challenges optimizing phaeosphaerides applications provide insights into future improve therapeutic potential. Moreover, our open a synthetic route analogues.

Язык: Английский

Процитировано

0
A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius, Huihui Zhao

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 712 - 712

Опубликована: Май 12, 2025

‘Blood stasis’ (syndrome) (BSS) is a fundamental concept in Traditional Chinese Medicine (TCM), where it known as Xue Yu (血瘀). Similar concepts exist Korean (‘Eohyul’) and Japanese Kampo medicine (Oketsu). Blood stasis considered to underpin large variety of inflammatory diseases, though an exact equivalent Western systems yet be described. Some time ago we discovered that blood can clot into anomalous amyloid form, creating what have referred fibrinaloid microclots. These microclots occur great many chronic, diseases are comparatively resistant fibrinolysis, thus the ability block microcapillaries hence lower oxygen transfer tissues, with multiple pathological consequences. We here develop idea precisely relate to, largely mechanistically responsible for, traditional (a term also used by Virchow). First, associated all stasis. Secondly, blocking red cell transport, provide simple mechanistic explanation for physical slowing down (‘stasis’) flow. Thirdly, herbal formulae proposed treat these especially Fu Zhu its derivatives, anticoagulatory anti-inflammatory, consistent they actually helping levels microclots, plausibly part catalysis polymerization fibrinogen form. rehearse some actions constituent herbs specific bioactive molecules contain. Consequently, such formulations (and their components), which little science medicine, would seem offer opportunity novel, safe, useful treatments chronic display including Myalgic Encephalopathy/Chronic Fatigue Syndrome, long COVID, even ischemic stroke.

Язык: Английский

Процитировано

0