THC and CBD: Villain versus Hero? Insights into Adolescent Exposure

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5251 - 5251

Опубликована: Март 9, 2023

Cannabis is the most used drug of abuse worldwide. It well established that abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). These two compounds have remarkably similar chemical structures yet vastly different effects brain. By binding to same receptors, THC psychoactive, while CBD has anxiolytic antipsychotic properties. Lately, a variety hemp-based products, including THC, become widely available food health industry, medical recreational use cannabis been legalized many states/countries. As result, people, youths, consuming because it considered “safe”. An extensive literature exists evaluating harmful both adults adolescents, but little known about long-term exposure, especially adolescence. The aim review collect preclinical clinical evidence cannabidiol.

Язык: Английский

---

HHC-induced psychosis: a case series of psychotic illness triggered by a widely available semisynthetic cannabinoid

Irish Journal of Psychological Medicine, Год журнала: 2024, Номер unknown, С. 1 - 4

Опубликована: Фев. 14, 2024

Abstract Use of both cannabis and synthetic cannabinoids has been regularly linked to the development psychotic illness. Thus, semisynthetic such as hexahydrocannabinol (HHC), which have a similar neurobiological profile delta-9-THC, may also be expected lead However, no relationship yet reported in scientific literature. HHC is readily available online many vape shops Ireland. Here, we present two cases illness appear precipitated by use legally purchased discuss its psychotogenic role factors current widespread availability.

Язык: Английский

---

Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return

Biomedicines, Год журнала: 2021, Номер 9(9), С. 1161 - 1161

Опубликована: Сен. 4, 2021

Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in nucleus accumbens (NAc). This study explores rats long-lasting effects of early intermittent exposure to intoxicating levels at adolescence, on: (1) response natural positive stimuli inescapable stress; (2) stress-axis functionality; (3) dopaminergic glutamatergic neuroadaptation NAc. We also assess potential non-intoxicating phytocannabinoid cannabidiol, counteract (or reverse) development detrimental consequences binge-like exposure. Our results show that adolescent alters sensitivity stimuli, exerts social novelty-triggered anxiety-like behaviour, passive stress-coping during prolonged withdrawal. In addition, serum corticosterone hypothalamic NAc corticotropin-releasing hormone progressively increase Besides, tyrosine hydroxylase late withdrawal, while expression dopamine transporter, D1 D2 receptors is dynamically altered binge Furthermore, markers excitatory postsynaptic signaling—PSD95; Homer-1 -2 activity-regulated spine-morphing proteins Arc, LIM Kinase 1 FOXP1—increase Notably, subchronic attenuates social- novelty-induced aversion rectifies hyper-responsive axis glutamate-related neuroplasticity. Overall, makes NAc, a locus minoris resistentiae as result perturbations neuroplasticity homeostasis. Cannabidiol holds promising for increasing behavioural, neuroendocrine molecular resilience against harmful effects.

Язык: Английский

---

A Case of First-Episode Psychosis with Catatonic Features in an Adolescent Following THC Use

Psychiatry Research Case Reports, Год журнала: 2025, Номер unknown, С. 100248 - 100248

Опубликована: Янв. 1, 2025

Язык: Английский

---

Mood, Motivation, and Mental Health

Опубликована: Янв. 1, 2025

Язык: Английский

---

Cannabis Use and Psychotic-Like Experiences: A Systematic Review of Biological Vulnerability, Potency Effects, and Clinical Trajectories

Psychiatry Research, Год журнала: 2025, Номер unknown, С. 116496 - 116496

Опубликована: Апрель 1, 2025

Язык: Английский

---

The dark side of “legal highs”: a case of psychosis in polysubstance use—A young psychonaut’s perspective

Journal of Substance Use, Год журнала: 2025, Номер unknown, С. 1 - 6

Опубликована: Апрель 20, 2025

Язык: Английский

---

Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally

Biological Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

Язык: Английский

---

Aberrant Salience Inventory: A meta‐analysis to investigate its psychometric properties and identify screening cutoff scores

Scandinavian Journal of Psychology, Год журнала: 2023, Номер 64(6), С. 734 - 745

Опубликована: Май 26, 2023

Introduction The Aberrant Salience Inventory (ASI) is a useful tool to measure salience abnormalities among the general population. There strong clinical and scientific evidence that alteration linked psychosis. To present day, no meta‐analysis evaluating ASI's psychometric properties screening potential has been published. Materials Methods PubMed, Google Scholar, Scopus, Embase were searched using terms including “psychosis,” “schizophrenia,” “Aberrant Inventory.” Observational experimental studies employing ASI on populations of non‐psychotic controls patients with psychosis included. scores other demographic measures (age, gender, ethnicity) extracted as outcomes. Individual patients' data (IPD) collected. Exploratory factor analysis (EFA) was performed IPD. Results Eight articles finally included in meta‐analysis. differ significantly between psychotic populations; novel three‐factor model proposed regarding subscales structure. Theoretical positive predictive values (PPVs) negative (NPVs) calculated presented together different cutoff points depending preselected specific interest. Discussion PPV NPV reached levels adequate for be considered viable highlights presence subscale named “Unveiling experiences.” Implications meaning new structure are discussed, well tool.

Язык: Английский

---

Cannabidiol attenuates insular activity during motivational salience processing in patients with early psychosis

Psychological Medicine, Год журнала: 2022, Номер 53(10), С. 4732 - 4741

Опубликована: Июль 1, 2022

The mechanisms underlying the antipsychotic potential of cannabidiol (CBD) remain unclear but growing evidence indicates that dysfunction in insula, a key brain region involved processing motivationally salient stimuli, may have role pathophysiology psychosis. Here, we investigate whether CBD are underpinned by their effects on insular activation, known to be salience processing.A within-subject, crossover, double-blind, placebo-controlled investigation 19 healthy controls and 15 participants with early psychosis was conducted. Administration single dose compared placebo while performing monetary incentive delay task, an fMRI paradigm. Anticipation reward loss were used contrast stimuli against neutral control condition.No group differences activation between patients observed. Attenuation insula observed following CBD, placebo. Sensitivity analyses controlling for current cannabis use history did not affect main results.Our findings accordance existing suggesting modulates regions processing. Whether such underlie putative remains investigated.

Язык: Английский

---