Journal of Separation Science,
Год журнала:
2020,
Номер
43(9-10), С. 1838 - 1846
Опубликована: Фев. 18, 2020
Abstract
Lipidomics
plays
an
essential
role
in
the
development
of
improved
understanding
lipids
metabolism
and
identification
new
biomarkers
or
therapeutic
targets
related
diseases.
The
strong
analytical
power
mass
spectrometry
its
rapid
developments
respect
instruments
techniques
have
significantly
accelerated
emerging
lipidomics
application
fields
biology,
medicine,
pharmacy.
strategy
chemical
derivatization
can
remarkably
improve
shortcomings
spectrometric
technologies
shotgun
liquid
chromatography
spectrometry,
past
decade
many
studies
been
reported
for
fatty
acids,
glycerophospholipids,
sphingomyelins,
monoglycerides,
diacylglycerols,
long‐chain
bases,
steroids,
so
on.
Therefore,
this
review
will
focus
on
approaches
about
research
progresses
shotgun‐based
spectrometry–based
targeted
(from
2005
to
July
2019,
most
reports
emerged
5
years),
put
forward
problems
prospects
field.
It
is
expected
be
helpful
design
synthesis
reagents,
especially
outstanding
stable
isotope
labeling
strategies
matched
analysis
methods.
Lipids
are
crucial
components
of
cellular
function
owing
to
their
role
in
membrane
formation,
intercellular
signaling,
energy
storage,
and
homeostasis
maintenance.
In
the
brain,
lipid
dysregulations
have
been
associated
with
etiology
progression
neurodegeneration
other
neurological
pathologies.
Hence,
brain
lipids
emerging
as
important
potential
targets
for
early
diagnosis
prognosis
diseases.
This
review
aims
highlight
significance
usefulness
lipidomics
diagnosing
treating
We
explored
alterations
diseases,
paying
attention
organ-specific
characteristics
functions
lipids.
As
recent
advances
would
impossible
without
analytical
techniques,
we
provide
up-to-date
information
on
mass
spectrometric
approaches
integrative
analysis
omic
approaches.
Last,
present
applications
combined
artificial
intelligence
techniques
interdisciplinary
collaborative
research
diseases
clinical
heterogeneities.
Journal of Clinical Investigation,
Год журнала:
2023,
Номер
133(1)
Опубликована: Янв. 2, 2023
Glioblastoma
(GBM)
is
a
primary
tumor
of
the
brain
defined
by
its
uniform
lethality
and
resistance
to
conventional
therapies.
There
have
been
considerable
efforts
untangle
metabolic
underpinnings
this
disease
find
novel
therapeutic
avenues
for
treatment.
An
emerging
focus
in
field
fatty
acid
(FA)
metabolism,
which
critical
numerous
diverse
biological
processes
involved
GBM
pathogenesis.
These
can
be
classified
into
four
broad
fates:
anabolism,
catabolism,
regulation
ferroptosis,
generation
signaling
molecules.
Each
fate
provides
unique
perspective
we
inspect
biology
gives
us
road
map
understanding
complicated
field.
This
Review
discusses
basic,
translational,
clinical
insights
each
these
fates
provide
contemporary
FA
GBM.
It
clear,
based
on
literature,
that
there
are
far
more
questions
than
answers
metabolism
GBM,
substantial
should
made
complex
intractable
disease.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2249 - 2249
Опубликована: Фев. 13, 2024
Lipids
represent
a
large
group
of
biomolecules
that
are
responsible
for
various
functions
in
organisms.
Diseases
such
as
diabetes,
chronic
inflammation,
neurological
disorders,
or
neurodegenerative
and
cardiovascular
diseases
can
be
caused
by
lipid
imbalance.
Due
to
the
different
stereochemical
properties
composition
fatty
acyl
groups
molecules
most
classes,
quantification
lipids
development
lipidomic
analytical
techniques
problematic.
Identification
species
from
complex
matrices
is
difficult,
therefore
individual
steps,
which
include
extraction,
separation,
detection
lipids,
must
chosen
properly.
This
review
critically
documents
recent
strategies
analysis
sample
pretreatment
instrumental
data
interpretation
published
last
five
years
(2019
2023).
The
advantages
disadvantages
extraction
methods
covered.
step
comprises
identification
quantification.
Mass
spectrometry
(MS)
used
technique
analysis,
performed
direct
infusion
MS
approach
combination
with
suitable
separation
liquid
chromatography
gas
chromatography.
Special
attention
also
given
correct
evaluation
obtained
analyses.
Only
accurate,
precise,
robust
reliable
able
bring
useful
information,
may
contribute
clarification
some
at
molecular
level,
putative
biomarkers
and/or
therapeutic
targets.
Cosmetics,
Год журнала:
2021,
Номер
8(2), С. 52 - 52
Опубликована: Июнь 17, 2021
In
recent
years,
there
has
been
considerable
interest
in
using
microalgal
lipids
the
food,
chemical,
pharmaceutical,
and
cosmetic
industries.
Several
species
can
accumulate
appreciable
lipid
quantities
therefore
are
characterized
as
oleaginous.
formulations,
their
derivatives
one
of
main
ingredients.
Different
classes
great
moisturizing,
emollient,
softening
agents,
work
surfactants
emulsifiers,
give
consistence
to
products,
color
fragrance
carriers,
act
preservatives
maintain
products
integrity,
be
part
molecules
delivery
system.
past,
chemicals
have
widely
used
but
today’s
market
customers’
demands
oriented
towards
natural
products.
Microalgae
an
extraordinary
source
other
many
bioactive
molecules.
Scientists’
attention
microalgae
cultivation
for
industrial
application
is
increasing.
For
high
costs
associated,
commercialization
still
not
very
widespread.
The
possibility
use
biomass
various
purposes
could
make
more
economically
competitive.
Journal of the American Society for Mass Spectrometry,
Год журнала:
2021,
Номер
32(11), С. 2655 - 2663
Опубликована: Окт. 12, 2021
Differential
mobility
spectrometry
(DMS)
is
highly
useful
for
shotgun
lipidomic
analysis
because
it
overcomes
difficulties
in
measuring
isobaric
species
within
a
complex
lipid
sample
and
allows
acyl
tail
characterization
of
phospholipid
species.
Despite
these
advantages,
the
resulting
workflow
presents
technical
challenges,
including
need
to
tune
DMS
before
every
batch
update
compensative
voltages
settings
method.
The
Sciex
Lipidyzer
platform
uses
5500
QTRAP
with
(SelexION),
an
LC
system
configured
direction
infusion
experiments,
extensive
set
standards
designed
quantitative
lipidomics,
software
package
(Lipidyzer
Workflow
Manager)
that
facilitates
rapidly
analyzes
data.
Although
remains
very
DMS-based
no
longer
updated
current
versions
Analyst
Windows.
Furthermore,
fixed
single
cannot
take
advantage
new
lipidomics
or
analyze
additional
To
address
this
multitude
issues,
we
developed
Shotgun
Lipidomics
Assistant
(SLA),
Python-based
application
workflows.
SLA
provides
user
flexibility
adding
subtracting
standard
MRMs.
It
can
report
results
from
raw
data
minutes,
comparable
software.
We
show
expanded
measures
over
1450
across
17
(sub)classes.
Lastly,
demonstrate
performs
isotope
correction,
feature
was
absent
original
Metabolites,
Год журнала:
2021,
Номер
11(1), С. 55 - 55
Опубликована: Янв. 15, 2021
Various
studies
aiming
to
elucidate
the
role
of
gut
microbiome-metabolome
co-axis
in
health
and
disease
have
primarily
focused
on
water-soluble
polar
metabolites,
whilst
non-polar
microbial
lipids
received
less
attention.
The
concept
microbiota-dependent
lipid
biotransformation
is
over
a
century
old.
However,
only
recently,
several
shown
how
alter
intestinal
circulating
concentrations
host,
thus
impacting
human
homeostasis.
There
emerging
evidence
that
communities
play
particularly
significant
regulation
host
cholesterol
sphingolipid
Here,
we
review
discuss
recent
research
focusing
microbe-host-lipid
co-metabolism.
We
also
interplay
microbiota
molecular
entering
systemic
circulation,
its
disease.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2021,
Номер
1867(5), С. 166079 - 166079
Опубликована: Янв. 19, 2021
Transport
proteins
are
essential
for
cells
in
allowing
the
exchange
of
substances
between
and
their
environment
across
lipid
bilayer
forming
a
tight
barrier.
Membrane
lipids
modulate
function
transmembrane
such
as
transporters
two
ways:
Lipids
tightly
specifically
bound
to
transport
addition
they
from
bulk
proteins.
This
overview
summarizes
currently
available
information
at
ultrastructural
level
on
impact
altered
membrane
composition.
Human
diseases
leading
homeostasis
will
lead
composition,
which
turn
affect
transporter
Cellular and Molecular Life Sciences,
Год журнала:
2021,
Номер
78(6), С. 2565 - 2584
Опубликована: Янв. 15, 2021
Cardiovascular
diseases
(CVDs)
are
the
leading
cause
of
mortality
and
morbidity
worldwide
to
31%
all
global
deaths.
Early
prediction
prevention
could
greatly
reduce
enormous
socio-economic
burden
posed
by
CVDs.
Plasma
lipids
have
been
at
center
stage
strategies
for
CVDs
that
mostly
relied
on
traditional
(total
cholesterol,
total
triglycerides,
HDL-C
LDL-C).
The
tremendous
advancement
in
field
lipidomics
last
two
decades
has
facilitated
research
efforts
unravel
metabolic
dysregulation
their
genetic
determinants,
enabling
understanding
pathophysiological
mechanisms
identification
predictive
biomarkers,
beyond
lipids.
This
review
presents
an
overview
application
epidemiological
studies
contributions
current
field.
We
findings
these
discuss
examples
demonstrates
potential
revealing
new
biology
not
captured
lipoprotein
measurements.
promising
from
raised
opportunities
fields
personalized
medicine
further
discusses
prospects
integrating
emerging
genomics
tools
with
high-dimensional
lipidome
move
forward
statistical
associations
towards
biological
understanding,
therapeutic
target
development
risk
prediction.
believe
holds
a
great
but
advancements
computational
needed
handle
correlated
lipidome.
