Tacrolimus
(FK506)
is
a
macrolide
lactone
immunosuppressive
drug
that
commonly
used
in
transplanted
patients
to
avoid
organ
rejection.
FK506
exhibits
high
inter-
and
intra-patient
pharmacokinetic
variability,
making
monitoring
necessary
for
graft
survival.
This
work
describes
the
development
of
novel
bioassay
FK506.
The
based
on
using
magnetic
Janus
micromotors
made
from
polycaprolactone
(PCL)
recombinant
chimera
receptor
incorporates
immunophilin
tacrolimus
binding
protein
1A
(FKBP1A)
tagged
with
Emerald
Green
Fluorescent
Protein
(EmGFP).
approach
relies
fluorescence
competitive
between
decorated
carboxylated
toward
specific
site
fluorescent
immunophilin.
proposed
homogeneous
assay
could
be
performed
single
step
without
wash
steps
separate
unbound
receptor.
fits
therapeutic
requirements,
showing
limit
detection
0.8
ng/mL
wide
dynamic
range
up
90
ng/mL.
Assay
selectivity
was
evaluated
by
measuring
inhibition
curves
other
drugs
usually
co-administered
propulsion
mechanism
allows
efficient
operation
raw
samples
damaging
biological
(FKBP1A-EmGFP).
enhanced
target
recognition
micromixing
strategies
hold
considerable
potential
practical
clinical
use.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(5), С. 2284 - 2299
Опубликована: Янв. 1, 2024
A
biofilm
constitutes
a
bacterial
community
encased
in
sticky
matrix
of
extracellular
polymeric
substances.
These
intricate
microbial
communities
adhere
to
various
host
surfaces
such
as
hard
and
soft
tissues
well
indwelling
medical
devices.
aggregates
form
robust
substances
(EPSs),
leading
the
majority
human
infections.
Such
infections
tend
exhibit
high
resistance
treatment,
often
progressing
into
chronic
states.
The
EPS
protects
bacteria
from
hostile
environment
prevents
penetration
antibacterial
agents.
Modern
robots
at
nano,
micro,
millimeter
scales
are
highly
attractive
candidates
for
biomedical
applications
due
their
diverse
functionalities,
navigating
confined
spaces
targeted
multitasking.
In
this
tutorial
review,
we
describe
key
milestones
strategies
developed
removal
eradication
biofilms
using
different
sizes
shapes.
It
can
be
seen
that
useful
effective
tools
treating
biofilms,
thus
preventing
persistent
infections,
loss
costly
implanted
devices,
additional
costs
associated
with
hospitalization
therapies.
Nano Letters,
Год журнала:
2023,
Номер
23(7), С. 2502 - 2510
Опубликована: Март 16, 2023
Self-propelled
micro/nanomotors
are
emergent
intelligent
sensors
for
analyzing
extracellular
biomarkers
in
circulating
biological
fluids.
Conventional
luminescent
motors
often
masked
by
a
highly
dynamic
and
scattered
environment,
creating
challenges
to
characterize
or
subtle
binding
dynamics.
Here
we
introduce
strategy
amplify
signals
coupling
strong
light–matter
interactions
on
micromotors.
A
smart
whispering-gallery-mode
microlaser
that
can
self-propel
analyze
is
demonstrated
through
liquid
crystal
microdroplet.
Lasing
spectral
responses
induced
cavity
energy
transfer
were
employed
reflect
the
abundance
of
protein
biomarkers,
generating
exclusive
molecular
labels
cellular
profiling
exosomes
derived
from
3D
multicellular
cancer
spheroids.
Finally,
microfluidic
biosystem
with
different
tumor-derived
was
elaborate
its
sensing
capability
complex
environments.
The
proposed
autonomous
exhibits
promising
method
both
fundamental
science
applications
drug
screening,
phenotyping,
organ-on-chip
applications.
The European Physical Journal E,
Год журнала:
2025,
Номер
48(2)
Опубликована: Фев. 1, 2025
In
the
past
years,
amount
of
research
on
active
matter
has
grown
extremely
rapidly,
a
fact
that
is
reflected
in
particular
by
existence
more
than
1000
reviews
this
topic.
Moreover,
field
become
very
diverse,
ranging
from
theoretical
studies
statistical
mechanics
particles
to
applied
work
medical
applications
microrobots
and
biological
systems
artificial
swimmers.
This
makes
it
difficult
get
an
overview
over
as
whole.
Here,
we
provide
such
form
metareview
article
surveys
existing
review
articles
books
matter.
Thereby,
provides
useful
starting
point
for
finding
literature
about
specific
Nano Letters,
Год журнала:
2023,
Номер
23(6), С. 2379 - 2387
Опубликована: Март 7, 2023
Detection
of
biomolecules
is
essential
for
patient
diagnosis,
disease
management,
and
numerous
other
applications.
Recently,
nano-
microparticle-based
detection
has
been
explored
improving
traditional
assays
by
reducing
required
sample
volumes
assay
times
as
well
enhancing
tunability.
Among
these
approaches,
active
particle-based
that
couple
particle
motion
to
biomolecule
concentration
expand
accessibility
through
simplified
signal
outputs.
However,
most
approaches
require
secondary
labeling,
which
complicates
workflows
introduces
additional
points
error.
Here,
we
show
a
proof-of-concept
label-free,
motion-based
system
using
electrokinetic
particles.
We
prepare
induced-charge
electrophoretic
microsensors
(ICEMs)
the
capture
two
model
biomolecules,
streptavidin
ovalbumin,
specific
leads
direct
transduction
ICEM
speed
suppression
at
concentrations
low
0.1
nM.
This
work
lays
foundation
new
paradigm
rapid,
simple,
label-free
Advanced Materials Interfaces,
Год журнала:
2024,
Номер
11(17)
Опубликована: Май 15, 2024
Abstract
Quantum
dots
(QDs)
are
recognized
as
the
most
promising
functional
nanotechnology,
for
which
its
discoverers
awarded
Nobel
Prize
in
2023.
Their
remarkable
tunability
of
optoelectronic
properties
has
attracted
significant
interest
from
both
researchers
and
industries,
placing
QDs
at
forefront
developing
cutting‐edge
technologies.
This
comprehensive
review
aims
to
explore
exciting
results
terms
fundamental
science,
present
forthcoming
applications.
Beyond
their
contributions
biomedicine,
energy,
environmental
quantum
sensing,
information
processing,
have
brought
important
due
integration
into
micro/nanorobotic
systems,
self‐propelled
materials
representing
state
art
research
micro
nanoscale.
These
hybrid
systems
demonstrated
noteworthy
outcomes,
unlocking
novel
possibilities
accurately
reviewed
this
article.
In
conclusion,
addresses
current
challenges,
offering
insights
facilitate
further
research,
stimulate
new
developments,
enhance
comprehension
full
potential
QDs.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(16)
Опубликована: Фев. 24, 2024
Abstract
Self‐propelled
micro/nanomotors
(MNMs)
have
shown
great
application
potential
in
biomedicine,
sensing,
environmental
remediation,
etc.
In
the
past
decade,
various
strategies
or
technologies
been
used
to
prepare
and
functionalize
MNMs.
However,
current
preparation
of
MNMs
were
mainly
following
pre‐designed
methods
based
on
specific
tasks
introduce
expected
functional
parts
micro/nanocarriers,
which
lacks
a
universal
platform
common
features,
making
it
difficult
apply
different
scenarios.
Here,
we
developed
modular
assembly
strategy
host–guest
chemistry,
enables
on‐demand
construction
imaging‐trackable
nanomotors
mounted
with
suitable
driving
imaging
modules
using
platform,
according
These
assembled
exhibited
enhanced
diffusion
behavior
driven
by
enzymatic
reactions.
The
loaded
functions
dynamically
trace
swarm
motion
corresponding
fuel
conditions
both
vitro
vivo.
endowed
interaction
provides
approach
producing
multifunctional
facile
controllable
manner,
paves
way
for
future
development
systems
programmable
functions.
