Evidence for reduced choroid plexus volume in the aged brain DOI Creative Commons

R Youh,

Charith Perera, Ian F. Harrison

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Background The choroid plexus plays an important role in brain homeostasis, including the active secretion of cerebrospinal fluid. Its function and structure have been reported to be affected by normal ageing. However, existing measures volume may complicated partial ( vivo MRI) tissue fixation artefacts (histology). In this study, we investigate possible changes within lateral ventricles aged mice utilising two structural MRI protocols explicitly designed for time-efficient, high-resolution imaging plexus. Methods Two sequences were utilised examine young (∼6 months) (∼24 mouse brains: 1) ultra-long echo-time T2 weighted fast-spin-echo 2) a multi-TE T2* mapping protocol. A test-retest study was performed on subset data reproducibility estimation. two-way ANOVA test determine differences groups across distinct protocols. Results Reproducibility tests showed low variability manual segmentation pipeline both statistically significant reduction found brain. This finding is concordant with previous histology studies that observed epithelial cell height ageing wide range species. Conclusions We present investigation ventricle approach based bespoke time-efficient high resolution Furthermore, these protocols, provide evidence research provides insight measurements as biomarker age-related neurologic conditions it indicates process itself does not result hypertrophy plexus, but decrease volume.

Язык: Английский

Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease DOI
D. Botta,

Ioana Hutuca,

Elyas El Ghoul

и другие.

Journal of Neuroradiology, Год журнала: 2025, Номер 52(3), С. 101322 - 101322

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

3
Clinical, immunological and neuroimaging spectrum of CNS lupus: can we reliably differentiate it from MS? DOI Creative Commons
Anna Wójcicka-Frankiewicz, Mikołaj A. Pawlak, Alicja Kalinowska-Łyszczarz

и другие.

Neurologia i Neurochirurgia Polska, Год журнала: 2024, Номер 58(6), С. 557 - 568

Опубликована: Дек. 27, 2024

Язык: Английский

Процитировано

0
Evidence for reduced choroid plexus volume in the aged brain DOI Creative Commons

R Youh,

Charith Perera, Ian F. Harrison

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Abstract Background The choroid plexus plays an important role in brain homeostasis, including the active secretion of cerebrospinal fluid. Its function and structure have been reported to be affected by normal ageing. However, existing measures volume may complicated partial ( vivo MRI) tissue fixation artefacts (histology). In this study, we investigate possible changes within lateral ventricles aged mice utilising two structural MRI protocols explicitly designed for time-efficient, high-resolution imaging plexus. Methods Two sequences were utilised examine young (∼6 months) (∼24 mouse brains: 1) ultra-long echo-time T2 weighted fast-spin-echo 2) a multi-TE T2* mapping protocol. A test-retest study was performed on subset data reproducibility estimation. two-way ANOVA test determine differences groups across distinct protocols. Results Reproducibility tests showed low variability manual segmentation pipeline both statistically significant reduction found brain. This finding is concordant with previous histology studies that observed epithelial cell height ageing wide range species. Conclusions We present investigation ventricle approach based bespoke time-efficient high resolution Furthermore, these protocols, provide evidence research provides insight measurements as biomarker age-related neurologic conditions it indicates process itself does not result hypertrophy plexus, but decrease volume.

Язык: Английский

Процитировано

0