Considerations for Domestication of Novel Strains of Filamentous Fungi

ACS Synthetic Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Fungi, especially filamentous fungi, are a relatively understudied, biotechnologically useful resource with incredible potential for commercial applications. These multicellular eukaryotic organisms have long been exploited their natural production of commodity chemicals and proteins such as enzymes used in starch processing, detergents, food feed production, pulping paper making biofuels production. The ability fungi to use wide range feedstocks is another key advantage. As chassis organisms, can express cellular machinery, metabolic signal transduction pathways from both prokaryotic origins. Their genomes abound novel genetic elements processes that be harnessed biotechnology Synthetic biology tools becoming inexpensive, modular, expansive while systems beginning provide the level understanding required design increasingly complex synthetic systems. This review covers challenges working offers perspective on approaches needed exploit microbial cell factories.

Язык: Английский

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Application and Progress of Genomics in Deciphering the Genetic Regulation Mechanisms of Plant Secondary Metabolites

Plants, Год журнала: 2025, Номер 14(9), С. 1316 - 1316

Опубликована: Апрель 26, 2025

This review aims to systematically dissect the genetic regulatory mechanisms of plant secondary metabolites in era genomics, while comprehensively summarizing progress and potential impact genomics metabolism research. By integrating methodologies such as high-throughput sequencing, structural comparative functional we elucidate principles underlying identify genes. The application these technologies has deepened our understanding metabolic pathways driven advancements molecular genetics genomics. development enabled scientists gain profound insights into biosynthetic plants ginseng (Panax ginseng) grapevine (Vitis vinifera), offering novel possibilities for precise regulation pathways. Despite remarkable studying metabolites, significant challenges persist. Future research must focus on multi-omics data, developing advanced bioinformatics tools, exploring effective improvement strategies fully harness medicinal enhance their capacity synthesize metabolites.

Язык: Английский

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Epigenetic Regulation of Fungicide Resistance in Plant‐Pathogenic Fungi

Plant Pathology, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

ABSTRACT Fungicides have been successfully used to control plant‐pathogenic fungi in agriculture, but their continuous use has led resistance developing against all significant fungicide modes of action worldwide. Notably, Phytophthora , Fusarium and Verticillium are the most troublesome plant pathogens with regard resistance. In fungi, epigenetic mechanisms play critical roles by increasing stress‐adaptive potential rapidly changing environments. These involve alterations expression genetic elements without changes DNA sequence. The role contributing survival fitness under various stresses is not well documented fungi. Studies shown differential methyltransferases, histone methyltransferases demethylases response fungicides; however, further research needed. Exploring how these processes affect gene patterns subjected recurrent selection crucial. Therefore, this mini‐review will focus on contributions adaptive responses stress. A better understanding enhance our knowledge evolution pathogens, potentially leading development fungicides novel targets.

Язык: Английский

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Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma

Applied Microbiology and Biotechnology, Год журнала: 2022, Номер 106(8), С. 3033 - 3049

Опубликована: Апрель 1, 2022

Язык: Английский

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Development of cellulolytic strain by genetic engineering approach for enhanced cellulase production

Elsevier eBooks, Год журнала: 2020, Номер unknown, С. 103 - 136

Опубликована: Янв. 1, 2020

Язык: Английский

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