Considerations for Domestication of Novel Strains of Filamentous Fungi

ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Fungi, especially filamentous fungi, are a relatively understudied, biotechnologically useful resource with incredible potential for commercial applications. These multicellular eukaryotic organisms have long been exploited their natural production of commodity chemicals and proteins such as enzymes used in starch processing, detergents, food feed production, pulping paper making biofuels production. The ability fungi to use wide range feedstocks is another key advantage. As chassis organisms, can express cellular machinery, metabolic signal transduction pathways from both prokaryotic origins. Their genomes abound novel genetic elements processes that be harnessed biotechnology Synthetic biology tools becoming inexpensive, modular, expansive while systems beginning provide the level understanding required design increasingly complex synthetic systems. This review covers challenges working offers perspective on approaches needed exploit microbial cell factories.

Language: Английский

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Application and Progress of Genomics in Deciphering the Genetic Regulation Mechanisms of Plant Secondary Metabolites

Plants, Journal Year: 2025, Volume and Issue: 14(9), P. 1316 - 1316

Published: April 26, 2025

This review aims to systematically dissect the genetic regulatory mechanisms of plant secondary metabolites in era genomics, while comprehensively summarizing progress and potential impact genomics metabolism research. By integrating methodologies such as high-throughput sequencing, structural comparative functional we elucidate principles underlying identify genes. The application these technologies has deepened our understanding metabolic pathways driven advancements molecular genetics genomics. development enabled scientists gain profound insights into biosynthetic plants ginseng (Panax ginseng) grapevine (Vitis vinifera), offering novel possibilities for precise regulation pathways. Despite remarkable studying metabolites, significant challenges persist. Future research must focus on multi-omics data, developing advanced bioinformatics tools, exploring effective improvement strategies fully harness medicinal enhance their capacity synthesize metabolites.

Language: Английский

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Epigenetic Regulation of Fungicide Resistance in Plant‐Pathogenic Fungi

Plant Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

ABSTRACT Fungicides have been successfully used to control plant‐pathogenic fungi in agriculture, but their continuous use has led resistance developing against all significant fungicide modes of action worldwide. Notably, Phytophthora , Fusarium and Verticillium are the most troublesome plant pathogens with regard resistance. In fungi, epigenetic mechanisms play critical roles by increasing stress‐adaptive potential rapidly changing environments. These involve alterations expression genetic elements without changes DNA sequence. The role contributing survival fitness under various stresses is not well documented fungi. Studies shown differential methyltransferases, histone methyltransferases demethylases response fungicides; however, further research needed. Exploring how these processes affect gene patterns subjected recurrent selection crucial. Therefore, this mini‐review will focus on contributions adaptive responses stress. A better understanding enhance our knowledge evolution pathogens, potentially leading development fungicides novel targets.

Language: Английский

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Histone acetyltransferase GCN5-mediated lysine acetylation modulates salt stress aadaption of Trichoderma

Applied Microbiology and Biotechnology, Journal Year: 2022, Volume and Issue: 106(8), P. 3033 - 3049

Published: April 1, 2022

Language: Английский

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Development of cellulolytic strain by genetic engineering approach for enhanced cellulase production

Elsevier eBooks, Journal Year: 2020, Volume and Issue: unknown, P. 103 - 136

Published: Jan. 1, 2020

Language: Английский

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