Knockdown of lncRNA SNHG4 suppresses gastric cancer cell proliferation and metastasis by targeting miR-204-5p

Neoplasma, Год журнала: 2021, Номер 68(03), С. 546 - 556

Опубликована: Янв. 1, 2021

Long non-coding RNAs (lncRNAs) have been identified as critical regulators in gastric cancer (GC) progression.However, whether lncRNA small nucleolar host gene 4 (SNHG4) functions GC development remains unknown.In this study, the bio-functional role of SNHG4 and its potential mechanism on progression were systematically dissected.To investigate GC, we silenced using short hairpin (shRNAs) to perform loss-of-function assays.The results showed that expression cells was at a higher level compared normal mucosal epithelial cells.Knockdown dramatically suppressed proliferation, migration invasion, blocked cell cycle cells.Moreover, knockdown upregulated microRNA-204-5p (miR-204-5p) expression, whereas downregulated ribonucleotide reductase subunit M2 (RRM2) cells.Dual-luciferase reporter assay miR-204-5p direct target SNHG4.Additionally, tumorigenesis xenograft mouse models.Taken together, these data demonstrated by targeting miR-204-5p.

Язык: Английский

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LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review

Cytokine, Год журнала: 2024, Номер 179, С. 156585 - 156585

Опубликована: Апрель 4, 2024

Язык: Английский

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Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(18), С. 6658 - 6658

Опубликована: Сен. 11, 2020

The identification of cancer stem cells (CSCs) as initiators carcinogenesis has revolutionized the era research and our perception for disease treatment options. Additional CSC features, including self-renewal migratory invasive capabilities, have further justified these putative diagnostic, prognostic, therapeutic targets. Given plasticity, CSC-related biomarkers been a serious burden in characterization targeting. Over past decades, compelling amount evidence demonstrated critical regulatory functions non-coding RNAs (ncRNAs) on exclusive features CSCs. We now know that ncRNAs may interfere with signaling pathways, vital phenotype maintenance, such Notch, Wnt, Hedgehog. Here, we discuss multifaceted contribution microRNAs (miRNAs), long (lncRNAs) circular (circRNAs), representative ncRNA classes, sustaining CSC-like traits, well underlying molecular mechanisms their action various types. use high value.

Язык: Английский

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Silencing of Long Noncoding RNA SNHG6 Inhibits Esophageal Squamous Cell Carcinoma Progression via miR-186-5p/HIF1α Axis

Digestive Diseases and Sciences, Год журнала: 2019, Номер 65(10), С. 2844 - 2852

Опубликована: Дек. 18, 2019

Язык: Английский

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RETRACTED ARTICLE: LINC00665/miR-9-5p/ATF1 is a novel axis involved in the progression of colorectal cancer

Human Cell, Год журнала: 2020, Номер 33(4), С. 1142 - 1154

Опубликована: Авг. 10, 2020

Язык: Английский

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