Shijie huaren xiaohua zazhi, Год журнала: 2021, Номер 29(17), С. 990 - 998
Опубликована: Сен. 8, 2021
Язык: Английский
Journal of Experimental & Clinical Cancer Research, Год журнала: 2022, Номер 41(1)
Опубликована: Июль 1, 2022
Abstract Background One of the most malignant tumors in men is prostate cancer that still incurable due to its heterogenous and progressive natures. Genetic epigenetic changes play significant roles development. The RNA molecules with more than 200 nucleotides length are known as lncRNAs these factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional levels. LncRNAs vital biological functions cells pathological events, hence their undergoes dysregulation. Aim review role alterations development emphasized here. Therefore, were chosen for this purpose level interaction other signaling networks progression examined. Key scientific concepts aberrant has been well-documented rate tumor regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt PTEN, among molecular pathways. Furthermore, radio-resistance chemo-resistance features cells. Overexpression tumor-promoting such HOXD-AS1 CCAT1 can result drug resistance. Besides, induce immune evasion upregulating PD-1. Pharmacological compounds quercetin curcumin have applied targeting lncRNAs. siRNA tool reduce thereby suppressing progression. Prognosis diagnosis clinical course be evaluated by exosomal lncRNA-p21 investigated serum patients a reliable biomarker.
Язык: Английский
Процитировано
129
Cancer Medicine, Год журнала: 2022, Номер 12(3), С. 3185 - 3200
Опубликована: Июль 31, 2022
Abstract MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with length approximately 18‐25 nt nucleotides that regulate gene expression post‐transcriptionally. MiR‐204‐5p originates from the sixth intron transient receptor potential cation channel subfamily M member 3 (TRPM3) gene. is frequently downregulated in various cancer types and related to clinicopathological characteristics prognosis patients. So far, many studies have determined miR‐204‐5p functions as tumor suppressor for its extensive powerful capacity inhibit proliferation, metastasis, autophagy, chemoresistance multiple types. appears be promising prognostic biomarker therapeutic target human cancers. This review summarized latest advances on role
Язык: Английский
Процитировано
35
Cancer Cell International, Год журнала: 2021, Номер 21(1)
Опубликована: Окт. 30, 2021
Abstract Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers. LncRNAs are non-protein-coding of more than 200 nucleotides in length. Multiple studies been published on the relationship between lncRNA expression and progression human diseases. LncRNA small nucleolar RNA host gene 4 (SNHG4), a member SNHG family, is abnormally expressed variety diseases, including gastric cancer, renal cell carcinoma, glioblastoma, neuroblastoma, prostate colorectal osteosarcoma, cervical liver lung non-small-cell neonatal pneumonia, diabetic retinopathy, neuropathic pain, acute cerebral infarction, myeloid leukaemia, endometriosis. In this paper, structure SNHG4 first introduced, then humans, animal models cells summarized to highlight function above addition, specific mechanism as competing endogenous (ceRNA) discussed. The findings indicate that can be used biomarker for disease prognosis evaluation potential target diagnosis treatment.
Язык: Английский
Процитировано
30
APOPTOSIS, Год журнала: 2024, Номер 29(5-6), С. 835 - 848
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
3
Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(4)
Опубликована: Март 31, 2025
ABSTRACT Colorectal cancer (CRC) is a prevalent malignancy of the digestive system. Here, we explored role M2 macrophage‐derived extracellular vesicles (EVs) carrying long non‐coding RNA‐nuclear paraspeckle assembly transcript 1 (lncRNA‐NEAT1) in promoting CRC progression via regulation miR‐204‐5p/regulator ribosome synthesis (RRS1) axis and cell cycle dynamics. Firstly, differentiated WTHP‐1 cells into M0 macrophages transfected with sh‐NEAT1 lentivirus plasmids. EVs were isolated from administered to SW480 along miR‐204‐5p inhibitors or si‐RRS1 for 24 h. M2‐EVs‐derived lncRNA‐NEAT1 enhanced proliferation, migration, invasion, viability while reducing apoptosis. This was accompanied by increased expression RRS1, WEE1 G2 checkpoint kinase (WEE1), cyclin‐dependent (CDK1), CyclinB1, reduced levels, lower proportion G2/M phase. Knockdown reversed these effects. Mechanistically, functioned as competing endogenous RNA (ceRNA), sponging upregulate RRS1 expression. In summary, promote development modulating miR‐204‐5p/RRS1 axis, influencing These findings provide insights tumor‐promoting mechanisms CRC.
Язык: Английский
Процитировано
0
Cell Biochemistry and Biophysics, Год журнала: 2022, Номер 80(3), С. 483 - 494
Опубликована: Май 10, 2022
Язык: Английский
Процитировано
13
APOPTOSIS, Год журнала: 2022, Номер 28(3-4), С. 414 - 431
Опубликована: Дек. 9, 2022
Язык: Английский
Процитировано
12
Molecular Biology Reports, Год журнала: 2023, Номер 50(11), С. 8995 - 9006
Опубликована: Сен. 16, 2023
Язык: Английский
Процитировано
7
European journal of medical research, Год журнала: 2024, Номер 29(1)
Опубликована: Июнь 4, 2024
Abstract The long non-coding RNA (lncRNA) Small Nucleolar Host Gene 4 (SNHG4) has been demonstrated to be significantly downregulated in various inflammatory conditions, yet its role chronic obstructive pulmonary disease (COPD) remains elusive. This study aims elucidate the biological function of SNHG4 COPD and unveil potential molecular targets. Our findings reveal that both Four a Half LIM Domains 1 (FHL1) were markedly COPD, whereas microRNA-409-3p (miR-409-3p) was upregulated. Importantly, exhibited negative correlation with markers patients but positive forced expiratory volume 1s percentage (FEV1%). distinguished from non-smokers high sensitivity, specificity, accuracy. Overexpression ameliorated cigarette smoke extract (CSE)-mediated inflammation, apoptosis, oxidative stress, airway remodeling 16HBE bronchial epithelial cells. These beneficial effects overexpression reversed by miR-409-3p or silencing FHL1. Mechanistically, competitively bound miR-409-3p, mediating expression FHL1, consequently improving Additionally, regulated miR-409-3p/FHL1 axis inhibit activation mitogen-activated protein kinase (MAPK) pathway induced CSE. In murine model knockdown exacerbated CSE-induced stress. summary, our data affirm mitigates damage mediated through regulation axis. Graphical
Язык: Английский
Процитировано
2
Molecular Biotechnology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 8, 2024
Abstract Long intergenic non-coding RNA 239 ( Linc00239 ) acts as an oncogene in colorectal cancer (CRC), esophageal squamous cell carcinoma, and acute myeloid leukemia cells. However, its role regulatory mechanisms clear renal carcinoma (ccRCC) remain unknown. We used StarBase The Cancer Genome Atlas databases to evaluate expression effect on ccRCC. Furthermore, the function of ccRCC proliferation metastasis was analyzed using Cell Counting Kit-8 Transwell assays following knockdown. Subsequently, -miRNA-mRNA associations were selected based miRanda, miTarbase, previous references, their levels binding relationship further validated quantitative real-time polymerase chain reaction, western blotting dual-luciferase reporter gene assay. Additionally, we transfected a miRNA inhibitor whether miR-204-5p/ RAB22A (Ras-related proteins brain 22a) axis involved function. elevated correlated with poor prognosis. knockdown inhibited progression. inhibition miR-204-5p repressed levels. Moreover, inhibitors attenuated this inhibitory proliferation, migration, invasion, level when knocked down. promotes by elevating through adsorption miR-204-5p, which provides clue for diagnosis treatment
Язык: Английский
Процитировано
2