Regulated cell death (RCD) in cancer: key pathways and targeted therapies

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Авг. 13, 2022

Regulated cell death (RCD), also well-known as programmed (PCD), refers to the form of that can be regulated by a variety biomacromolecules, which is distinctive from accidental (ACD). Accumulating evidence has revealed RCD subroutines are key features tumorigenesis, may ultimately lead establishment different potential therapeutic strategies. Hitherto, targeting with pharmacological small-molecule compounds been emerging promising avenue, rapidly progressed in many types human cancers. Thus, this review, we focus on summarizing not only apoptotic and autophagy-dependent signaling pathways, but crucial pathways other subroutines, including necroptosis, pyroptosis, ferroptosis, parthanatos, entosis, NETosis lysosome-dependent (LCD) cancer. Moreover, further discuss current situation several improve cancer treatment, such single-target, dual or multiple-target compounds, drug combinations, some new strategies would together shed light future directions attack vulnerabilities drugs for purposes.

Язык: Английский

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The Influence of Cell Cycle Regulation on Chemotherapy

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(13), С. 6923 - 6923

Опубликована: Июнь 28, 2021

Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell signaling pathways, vital for proliferation, growth, repair. The occurrence, development, metastasis tumors are closely related to the cycle. can be synergistic with chemotherapy in two aspects: inhibition or promotion. sensitivity tumor cells chemotherapeutic drugs improved cooperation strategies. This review presented mechanism commonly used effect on tumorigenesis interaction cancer treatment was briefly introduced. current collaborative strategies discussed detail. Finally, we outline challenges perspectives about improvement combination therapy.

Язык: Английский

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Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours

EBioMedicine, Год журнала: 2020, Номер 59, С. 102943 - 102943

Опубликована: Авг. 17, 2020

Mitochondria are dynamic organelles that have essential metabolic activity and regarded as signalling hubs with biosynthetic, bioenergetics functions orchestrate key biological pathways. However, mitochondria can influence all processes linked to oncogenesis, starting from malignant transformation metastatic dissemination. In this review, we describe how alterations in the mitochondrial status contribute acquisition of typical traits, discussing most recent discoveries many unanswered questions. We also highlight expanding our understanding regulation function mechanisms context cancer cell metabolism could be an important task biomedical research, thus offering possibility targeting for treatment cancer.

Язык: Английский

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Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis

Environmental Pollution, Год журнала: 2022, Номер 307, С. 119449 - 119449

Опубликована: Май 9, 2022

Язык: Английский

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PI3K/Akt/mTOR signaling pathway in cancer stem cells

Pathology - Research and Practice, Год журнала: 2022, Номер 237, С. 154010 - 154010

Опубликована: Июль 3, 2022

Язык: Английский

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Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Апрель 12, 2022

Abstract Triple-negative breast cancer (TNBC) is a subtype of human with one the worst prognoses, no targeted therapeutic strategies currently available. Regulated cell death (RCD), also known as programmed (PCD), has been widely reported to have numerous links progression and therapy many types cancer. Of note, RCD can be divided into different subroutines, including autophagy-dependent death, apoptosis, mitotic catastrophe, necroptosis, ferroptosis, pyroptosis anoikis. More recently, targeting subroutines small-molecule compounds emerging promising strategy, which rapidly progressed in treatment TNBC. Therefore, this review, we focus on summarizing molecular mechanisms above-mentioned seven major related TNBC latest progress subroutines. Moreover, further discuss combined drug (e.g., narciclasine) or more drugs torin-1 chloroquine) achieve potential by regulating importantly, demonstrate several ONC201 NCT03733119) clinical trials. Taken together, these findings will provide clue illuminating actionable low-hanging-fruit druggable targets candidate for RCD-related therapies. Graphical abstract

Язык: Английский

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Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 152, С. 113208 - 113208

Опубликована: Май 31, 2022

This study aimed to reveal the classical signal pathways and important potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD), provide support further investigation on TCM its active ingredients.Literature survey was conducted using PubMed, Web Science, Google Scholar, CNKI, other databases, with "Alzheimer's disease," "traditional medicine," "medicinal herb," "Chinese "natural plant" as primary keywords.TCM could modulate related AD pathological progression, including NF-κB, Nrf2, JAK/STAT, ubiquitin-proteasome pathway, autophagy-lysosome pathway-related AMPK/mTOR, GSK-3/mTOR, PI3K/Akt/mTOR, well SIRT1 PPARα pathway. It regulate crosstalk between through a multitarget, thus maintaining chronic inflammatory interaction balance, inhibiting oxidative stress damage, regulating system function, modulating autophagy, eventually improving cognitive impairment in patients AD.TCM be multilevel, multitargeted, multifaceted prevent treat AD. In-depth research prevention treatment new ideas exploring pathogenesis developing anti-AD drugs.

Язык: Английский

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Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1848 - 1848

Опубликована: Фев. 3, 2024

Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year.

Язык: Английский

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Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy

Journal of Neuroinflammation, Год журнала: 2023, Номер 20(1)

Опубликована: Фев. 10, 2023

Patients with hypertension have a risk of depression. Morinda officinalis oligosaccharides (MOOs) anti-depressant properties. In this study, we aimed to determine whether MOOs can improve the symptoms depression in individuals hypertension.Dahl salt-sensitive rats fed high-salt diet were stimulated by chronic unpredictable mild stress mimic Primary astrocytes and neurons isolated from these rats. Astrocytes underwent LPS stimulation simulate inflammatory during administrated at 0.1 mg/g/day vivo 1.25, 2.5, 5 mg/mL vitro. Mitophagy was inhibited using mM 3-methyladenine (3-MA). Astrocyte-mediated neurotoxicity detected co-culturing neurons.MOOs decreased systolic pressure, diastolic mean arterial thereby improving depression-like behavior, including behavioral despair, lack enthusiasm, loss pleasure Furthermore, inflammation, astrocytic dysfunction, mitochondrial damage brain. Then, promoted autophagosome lysosome enriched mitochondria LPS-stimulated astrocytes. suppressed release tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1β undergoing stimulation. Importantly, rescued impaired co-cultured The effects on reversed 3-MA. Finally, upregulated LPS-downregulated Mfn2 expression inhibition partly Intriguingly, suppression activated PI3K/Akt/mTOR pathway treatment.Astrocytes develop neuroinflammation response activate pathway-mediated mitophagy, removing astrocytes.1. anti-hypertensive anti-depressive 2. inhibit inflammation injury 3. induce mitophagy activation damage. 4. upregulate 5. activates resist

Язык: Английский

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Hepatocellular carcinoma: signaling pathways, targeted therapy, and immunotherapy

MedComm, Год журнала: 2024, Номер 5(2)

Опубликована: Фев. 1, 2024

Abstract Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high mortality rate. It regarded as significant public health issue because of its complicated pathophysiology, metastasis, and recurrence rates. There are no obvious symptoms in early stage HCC, which often leads to delays diagnosis. Traditional treatment methods such surgical resection, radiotherapy, chemotherapy, interventional therapies have limited therapeutic effects for HCC patients or metastasis. With development molecular biology immunology, signaling pathways immune checkpoint were identified main mechanism progression. Targeting these molecules has become new direction HCC. At present, combination targeted drugs inhibitors first choice advanced patients. In this review, we mainly focus on cutting‐edge research corresponding therapy immunotherapy great significance comprehensively understand pathogenesis search potential targets, optimize strategies

Язык: Английский

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