Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119642 - 119642
Опубликована: Март 1, 2025
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 88, С. 101960 - 101960
Опубликована: Май 22, 2023
Язык: Английский
Процитировано
51
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114312 - 114312
Опубликована: Май 19, 2023
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by massive loss of specific neurons. It is a progressive disabling, severe and fatal complex disease. Due to its pathogenesis limitations clinical treatment strategies, it poses serious medical challenge burden worldwide. The AD not clear, potential biological mechanisms include aggregation soluble amyloid form insoluble plaques, abnormal phosphorylation tau protein formation intracellular neurofibrillary tangles (NFT), neuroinflammation, ferroptosis, oxidative stress metal ion disorders. Among them, ferroptosis newly discovered programmed cell death induced iron-dependent lipid peroxidation reactive oxygen species. Recent studies have shown that closely related AD, but the mechanism remains unclear. may be iron metabolism, amino acid metabolism affecting accumulation ions. Some chelating agents (deferoxamine, deferiprone), chloroiodohydroxyquine derivatives, antioxidants (vitamin E, lipoic acid, selenium), derivatives Fer-1, tet, etc. been in animal effective exert neuroprotective effects. This review summarizes regulation natural plant products on order provide reference information for future research development inhibitors.
Язык: Английский
Процитировано
47
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1098 - 1098
Опубликована: Янв. 27, 2025
This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.
Язык: Английский
Процитировано
1
Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Background Alzheimer's disease (AD) is an irreversible age-related neurodegenerative condition characterized by the deposition of amyloid-β (Aβ) peptides and neurofibrillary tangles. Di Huang Yi Zhi (DHYZ) formula, a traditional Chinese herbal compound comprising several prescriptions, demonstrates properties that improve cognitive abilities in clinical. Nonetheless, its molecular mechanisms on treating AD through improving neuron cells mitochondria function have not been deeply investigated. Objective This study administered DHYZ to APP/PS1 mice explore potential therapeutic treatment. Methods transgenic were given (L, M, H), donepezil, or distilled water for consecutive 12-week period. The Morris maze test was used assess memory capacity, transmission electron microscopy observe mitochondrial synaptic structures, immunohistochemistry western blot detected proteins involved autophagy pathway, ELISA measured serum Aβ content, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assessed neuronal cell apoptosis. Results notable impact with AD, effectively impairments. decreases accumulation hippocampus reducing BACE1 activity enhancing clearance blood-brain barrier. Additionally, significantly suppresses apoptosis, enhances structure, increases synapse numbers, processes strongly linked activation PINK1-Parkin autophagy. Conclusions stimulating pathway.
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2023, Номер 13(5), С. 816 - 816
Опубликована: Май 11, 2023
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning knowledge that disease intimately tied to neurodegenerative disorders, affecting both central and peripheral nervous systems well leading dementia, seventh cause of death. New innovative therapeutic strategies address metabolism, apoptosis, autophagy, pyroptosis, mechanistic target rapamycin (mTOR), AMP activated protein kinase (AMPK), growth factor signaling with erythropoietin (EPO), risk factors apolipoprotein E (APOE-ε4) gene coronavirus 2019 (COVID-19) can offer valuable insights for clinical care treatment disorders impacted by disease. Critical insight into modulation these complex pathways are required since mTOR pathways, AMPK activation, improve memory retention in Alzheimer's (AD) DM, promote healthy aging, facilitate clearance β-amyloid (Aß) tau brain, control inflammation, but also may lead cognitive loss long-COVID syndrome through mechanisms include oxidative stress, mitochondrial cytokine release, APOE-ε4 if autophagy other programmed cell death left unchecked.
Язык: Английский
Процитировано
21
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Ноя. 8, 2023
Life expectancy is increasing throughout the world and coincides with a rise in non-communicable diseases (NCDs), especially for metabolic disease that includes diabetes mellitus (DM) neurodegenerative disorders. The debilitating effects of disorders influence entire body significantly affect nervous system impacting greater than one billion people disability peripheral as well cognitive loss, now seventh leading cause death worldwide. Metabolic disorders, such DM, neurologic remain significant challenge treatment care individuals since present therapies may limit symptoms but do not halt overall progression. These clinical challenges to address interplay between warrant innovative strategies can focus upon underlying mechanisms aging-related oxidative stress, cell senescence, death. Programmed pathways involve autophagy, apoptosis, ferroptosis, pyroptosis play critical role oversee processes include insulin resistance, β-cell function, mitochondrial integrity, reactive oxygen species release, inflammatory activation. silent mating type information regulation 2 homolog 1
Язык: Английский
Процитировано
20
Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11
Опубликована: Янв. 24, 2024
Diagnosis and treatment of patients with cardiovascular neurologic diseases primarily focus on the heart brain, respectively. An increasing number preclinical clinical studies have confirmed a causal relationship between brain diseases. Cardiogenic dementia is cognitive impairment caused by dysfunction has received research attention. The prevention cardiogenic are essential to improve quality life, particularly in elderly aging population. This study describes changes function associated coronary artery disease, myocardial infarction, failure, atrial fibrillation valve disease. updated understanding two known pathogenic mechanisms presented discussed. One cascade events cerebral hypoperfusion due long-term reduction cardiac output after other regardless blood flow injury. Furthermore, potential medications for reviewed, particular attention multicomponent herbal medicines.
Язык: Английский
Процитировано
7
Current Neurovascular Research, Год журнала: 2023, Номер 20(3), С. 314 - 333
Опубликована: Июль 25, 2023
Disorders of metabolism affect multiple systems throughout the body but may have greatest impact on both central and peripheral nervous systems. Currently available treatments behavior changes for disorders that include diabetes mellitus (DM) system diseases are limited cannot reverse disease burden. Greater access to healthcare a longer lifespan led an increased prevalence metabolic neurodegenerative disorders. In light these challenges, innovative studies into underlying pathways offer new treatment perspectives Alzheimer's Disease, Parkinson's Huntington's Disease. Metabolic intimately tied can lead debilitating outcomes, such as multi-nervous disease, susceptibility viral pathogens, long-term cognitive disability. Novel strategies robustly address involve careful consideration cellular metabolism, programmed cell death pathways, mechanistic target rapamycin (mTOR) its associated mTOR Complex 1 (mTORC1), 2 (mTORC2), AMP-activated protein kinase (AMPK), growth factor signaling, risk factors apolipoprotein E (APOE-ε4) gene. Yet, complex necessitate comprehensive understanding achieve clinical outcomes susceptibility, onset, progression.
Язык: Английский
Процитировано
15
Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 117976 - 117976
Опубликована: Март 16, 2024
Язык: Английский
Процитировано
5
Pharmacological Research - Modern Chinese Medicine, Год журнала: 2022, Номер 5, С. 100193 - 100193
Опубликована: Ноя. 11, 2022
Gallic acid and metformin are plant-derived compounds with biological effects. The present study aimed to evaluate the protective effect of gallic hesperidin against aluminium chloride (AlCl3)-induced Alzheimer's disease in Wistar rats. Thirty-five male rats were randomly distributed into seven groups five animals each. Group 1 was administered distilled water only, throughout study. Animals 2-5 received AlCl3 (100 mg/kg/day) Groups 3, 4 5 100 mg/kg/day acid,100 10 donepezil respectively, addition AlCl3. 6 7 treated only respectively. Treatments oral, as vehicle. lasted for 21 days. Cognitive impairment assessed by Morris maze Y on 21st day. Activities cholinesterases antioxidant enzymes, well levels reduced glutathione, malondialdehyde, neurotransmitters, caspase-3 cytokines evaluated brain. Results showed that caused an increase retention latency time reduction percentage alternation index experimental animals. However, treatment or prevented cognitive occasioned Moreover, significantly deficits neurotransmission, oxidative stress inflammation, while also lowering brain level. These observations corroborated results histopathological evaluation. from this suggest both conferred significant protection AlCl3–induced rats, their consumption could be relevant delaying onset disease.
Язык: Английский
Процитировано
19