Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Авг. 12, 2022

Abstract Given the spasmodic increment in antimicrobial resistance (AMR), world is on verge of “post-antibiotic era”. It anticipated that current SARS-CoV2 pandemic would worsen situation future, mainly due to lack new/next generation antimicrobials. In this context, nanoscale materials with potential have a great promise treat deadly pathogens. These functional are uniquely positioned effectively interfere bacterial systems and augment biofilm penetration. Most importantly, core substance, surface chemistry, shape, size nanomaterials define their efficacy while avoiding development AMR. Here, we review mechanisms AMR emerging applications as an excellent substitute for conventional antibiotics. We discuss potential, promises, challenges prospects nanobiotics combat Graphical

Язык: Английский

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Nanotechnology in the Diagnosis and Treatment of Antibiotic-Resistant Infections

Antibiotics, Год журнала: 2024, Номер 13(2), С. 121 - 121

Опубликована: Янв. 25, 2024

The development of antimicrobial resistance (AMR), along with the relative reduction in production new antimicrobials, significantly limits therapeutic options infectious diseases. Thus, novel treatments, especially current era, where AMR is increasing, are urgently needed. There several ongoing studies on non-classical therapies for diseases, such as bacteriophages, peptides, and nanotechnology, among others. Nanomaterials involve materials nanoscale that could be used diagnosis, treatment, prevention This review provides an overview applications nanotechnology diagnosis treatment diseases from a clinician’s perspective, focus pathogens AMR. Applications nanomaterials by taking advantage their electrochemical, optic, magnetic, fluorescent properties, described. Moreover, potential metallic or organic nanoparticles (NPs) infections also addressed. Finally, use NPs safe efficient vaccines reviewed. Further needed to prove safety efficacy would facilitate approval regulatory authorities clinical use.

Язык: Английский

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Advancing vaccine development in genomic era: A paradigm shift in vaccine discovery

Progress in Biomedical Engineering, Год журнала: 2025, Номер 7(2), С. 022004 - 022004

Опубликована: Фев. 5, 2025

Abstract The issue of antibiotic resistance is increasing with time because the quick rise microbial strains. Overuse antibiotics has led to multidrug-resistant, pan-drug-resistant, and extensively drug-resistant bacterial strains, which have worsened situation. Different techniques been considered applied combat this issue, such as developing new antibiotics, practicing stewardship, improving hygiene levels, controlling overuse. Vaccine development made a substantial contribution overcoming although it underestimated. In recent era, reverse vaccinology contributed different kinds vaccines against pathogens, revolutionizing vaccine process. Reverse helps prioritize better candidates by using various tools filter pathogen’s complete genome. review, we will shed light on computational designing, immunoinformatic tools, genomic proteomic data, challenges success stories designing.

Язык: Английский

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COVID-19 Vaccines: Current and Future Perspectives

Vaccines, Год журнала: 2022, Номер 10(4), С. 608 - 608

Опубликована: Апрель 13, 2022

Currently available vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are highly effective but not able to keep the coronavirus disease 2019 (COVID-19) pandemic completely under control. Alternative R&D strategies required induce a long-lasting immunological response and reduce adverse events as well favor rapid development large-scale production. Several technological platforms have been used develop COVID-19 vaccines, including inactivated viruses, recombinant proteins, DNA- RNA-based virus-vectored virus-like particles. In general, mRNA protein-based vectored shown high level of protection COVID-19. However, mutation-prone nature spike (S) protein affects vaccine its effectiveness, vaccinated people can become infected with new variants, also showing virus levels. addition, effects may occur, some them related interaction S angiotensin-converting enzyme 2 (ACE-2). Thus, there concerns that need be addressed challenges regarding logistic problems, such strict storage at low temperatures for vaccines. this review, we discuss limits developed possible innovative approaches.

Язык: Английский

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Current progress in the development of prophylactic and therapeutic vaccines

Science China Life Sciences, Год журнала: 2022, Номер 66(4), С. 679 - 710

Опубликована: Дек. 2, 2022

Язык: Английский

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Vaccine development for bacterial pathogens: Advances, challenges and prospects

Tropical Medicine & International Health, Год журнала: 2023, Номер 28(4), С. 275 - 299

Опубликована: Март 2, 2023

The advent and use of antimicrobials have played a key role in treating potentially life-threatening infectious diseases, improving health, saving the lives millions people worldwide. However, emergence multidrug resistant (MDR) pathogens has been significant health challenge that compromised ability to prevent treat wide range diseases were once treatable. Vaccines offer potential as promising alternative fight against antimicrobial resistance (AMR) diseases. Vaccine technologies include reverse vaccinology, structural biology methods, nucleic acid (DNA mRNA) vaccines, generalised modules for membrane antigens, bioconjugates/glycoconjugates, nanomaterials several other emerging technological advances are offering breakthrough development efficient vaccines pathogens. This review covers opportunities advancements vaccine discovery targeting bacterial We reflect on impact already-developed those currently under different stages preclinical clinical trials. More importantly, we critically comprehensively analyse challenges while highlighting indices future prospects. Finally, issues concerns AMR low-income countries (sub-Saharan Africa) with integration, this region evaluated.

Язык: Английский

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Impact of social media news on COVID-19 vaccine hesitancy and vaccination behavior

Telematics and Informatics, Год журнала: 2023, Номер 80, С. 101983 - 101983

Опубликована: Апрель 23, 2023

Язык: Английский

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In Silico Studies to Support Vaccine Development

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 654 - 654

Опубликована: Фев. 15, 2023

The progress that has been made in computer science positioned silico studies as an important and well-recognized methodology the drug discovery development process. It numerous advantages terms of costs also plays a huge impact on way research is conducted since it can limit use animal models leading to more sustainable research. Currently, human trials are already being partly replaced by trials. EMA FDA both endorsing these have providing webinars guidance support them. For instance, PBPK modeling used gather data interactions with other drugs clinical regulatory requirements for pediatric population, pregnant women, personalized medicine. This trend evokes need understand role vaccines, considering importance products achieved during pandemic their promising hope oncology. Vaccines safer than current oncology treatments. There variety strategies developing cancer vaccine, some points should be considered when designing vaccine technology following: delivery platforms (peptides, lipid-based carriers, polymers, dendritic cells, viral vectors, etc.), adjuvants (to boost promote inflammation at site, facilitating immune cell recruitment activation), choice targeted antigen, timing vaccination, manipulation tumor environment, combination treatments might cause additive or even synergistic anti-tumor effects. These many put together outline best design. aim this article perform review comprehensive analysis design vaccines field infectious diseases. authors intend literature all so far preparing methods vaccines. From point, was possible conclude there few Despite this, overview how existing work could described.

Язык: Английский

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Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Язык: Английский

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The Role of Nucleoprotein in Immunity to Human Negative-Stranded RNA Viruses—Not Just Another Brick in the Viral Nucleocapsid

Viruses, Год журнала: 2022, Номер 14(3), С. 521 - 521

Опубликована: Март 3, 2022

Negative-stranded RNA viruses (NSVs) are important human pathogens, including emerging and reemerging that cause respiratory, hemorrhagic other severe illnesses. Vaccine design traditionally relies on the viral surface glycoproteins. However, glycoproteins rarely elicit effective long-term immunity due to high variability. Therefore, an alternative approach is include conserved structural proteins such as nucleoprotein (NP). NP engaged in myriad processes life cycle: coating protection of RNA, regulation transcription/replication induction immunosuppression host. A broad heterosubtypic T-cellular was ascribed very early this protein. In contrast, understanding humoral limited spite titer non-neutralizing NP-specific antibodies raised upon natural infection or immunization. review, data with implications for role immune response NSVs revisited. Major elicited T-cell responses evaluated, possible multiple mechanisms neglected discussed. The intention review remind a promising target development future vaccines.

Язык: Английский

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