Sustainable utilization of fruit and vegetable waste bioresources for bioplastics production

Critical Reviews in Biotechnology, Год журнала: 2023, Номер 44(2), С. 236 - 254

Опубликована: Янв. 15, 2023

Nowadays, rapidly increasing production, use and disposable of plastic products has become one the utmost environmental issues. Our current circumstances in which food supply chain is demonstrated as containing particles other plastic-based impurities, represents a significant health risk to humans, animals, alike. According this point view, biodegradable material aims produce more sustainable greener world with lower ecological impact. Bioplastics are being investigated an environmentally friendly candidate address problem hence global bioplastic production seen growth expansion recent years. This article focuses on few critical issues that must be addressed for commercially viable. Although reduction fruit vegetable waste biomass apparent value terms benefits sustainability, commercial success at industrial scale remained flat. due various factors, including feedstocks, pretreatment technologies, enzymatic hydrolysis, scale-up industry, all contribute high capital operating costs. review paper summarizes overview bioplastics derived from biomass. Furthermore, economic technical challenges associated industrialization diverse applications biomedical, agricultural, food-packaging fields their excellent biocompatibility properties reviewed.HighlightsReview types characteristics sustainability biobased plasticsImproved technologies can develop enhance greater yieldEnzyme hydrolysis process used extraction & hasten scale-upFocus facing commercialized bioplasticsDetailed discussion application plastics

Язык: Английский

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What is the role of microbial biotechnology and genetic engineering in medicine?

MicrobiologyOpen, Год журнала: 2024, Номер 13(2)

Опубликована: Март 31, 2024

Abstract Microbial products are essential for developing various therapeutic agents, including antibiotics, anticancer drugs, vaccines, and enzymes. Genetic engineering techniques, functional genomics, synthetic biology unlock previously uncharacterized natural products. This review highlights major advances in microbial biotechnology, focusing on gene‐based technologies medical applications.

Язык: Английский

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Engineering Useful Microbial Species for Pharmaceutical Applications

Microorganisms, Год журнала: 2025, Номер 13(3), С. 599 - 599

Опубликована: Март 5, 2025

Microbial engineering has made a significant breakthrough in pharmaceutical biotechnology, greatly expanding the production of biologically active compounds, therapeutic proteins, and novel drug candidates. Recent advancements genetic engineering, synthetic biology, adaptive evolution have contributed to optimization microbial strains for applications, playing crucial role enhancing their productivity stability. The CRISPR-Cas system is widely utilized as precise genome modification tool, enabling enhancement metabolite biosynthesis activation biological pathways. Additionally, biology approaches allow targeted design microorganisms with improved metabolic efficiency potential, thereby accelerating development new products. integration artificial intelligence (AI) machine learning (ML) plays vital further advancing by predicting network interactions, optimizing bioprocesses, discovery process. However, challenges such efficient pathways, ensuring sustainable industrial-scale production, meeting international regulatory requirements remain critical barriers field. Furthermore, mitigate potential risks, it essential develop stringent biocontainment strategies implement appropriate oversight. This review comprehensively examines recent innovations analyzing key technological advancements, challenges, future perspectives.

Язык: Английский

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Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K3

BMC Microbiology, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 20, 2024

Язык: Английский

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Hairy-root technology: A metabolic engineering tool and specialized metabolite pathway elucidation and production of secondary metabolites. A review

Results in Engineering, Год журнала: 2024, Номер 23, С. 102697 - 102697

Опубликована: Авг. 9, 2024

Plants are primary source of essential secondary metabolites (SMs). Most these SMs have potential pharmaceutical, medicinal, and nutraceutical applications. However, the accumulate slowly in low amounts wild plants. Therefore, yields obtained from plant populations insufficient to meet need for commercialization. Consequently, this research gap has necessitates an ongoing study enhance production metabolites. Hairy root provides alternative important The transformation method is cost-effective due its ability supply fresh products throughout year. Currently, numerous genetic engineering approaches used enhancement metabolite production. This review comprehensively summarizes application metabolic hairy roots technology possible ways industrial scale-up desired demand

Язык: Английский

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Innovative antifungal Therapy: In vivo evaluation of 3-Ethyl-6,7-Dihydroxy-2-Phenyl-Chromen-4-One purified from Alpinia officinarum on Cryptococcus neoformans

International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114163 - 114163

Опубликована: Фев. 4, 2025

Язык: Английский

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Therapeutic and Preventive Effects of Natural Compounds Derived from Microbes

Springer eBooks, Год журнала: 2025, Номер unknown, С. 1 - 34

Опубликована: Янв. 1, 2025

Язык: Английский

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Exploring the potential of Rhizopus oryzae AUMC14899 as a novel endophytic fungus for the production of l-tyrosine and its biomedical applications

Microbial Cell Factories, Год журнала: 2023, Номер 22(1)

Опубликована: Фев. 20, 2023

Abstract Background A significant threat to the public's health is rise in antimicrobial resistance among numerous nosocomial bacterial infections. This may be a detriment present initiatives enhance of immune-compromised patients. Consequently, attention has been devoted exploring new bioactive compounds field drug discovery from endophytes. Therefore, this study first on production l -tyrosine (LT) as promising bio-therapeutic agent endophytic fungi. Results fungal isolate identified for time Rhizopus oryzae AUMC14899 Opuntia ficus-indica (L.) and submitted GenBank under accession number MZ025968. Separation amino acids crude extract was carried out, giving higher content LT, which then characterized purified. LT exhibited strong antibacterial anti-biofilm activities against multidrug-resistant Gram-negative Gram-positive bacteria. The recorded minimum inhibitory concentration (MIC) values ranged 6 20 µg/ml. In addition, caused reduction biofilm formation disrupted preformed biofilm. Moreover, results indicated that supported cell viability, evidencing hemocompatibility no cytotoxicity. Conclusion Our findings suggest potential therapeutic due its antibacterial, anti-biofilm, hemocompatibility, lack cytotoxic activities, also increase range therapy options skin burn infections, leading development novel fungal-based drug.

Язык: Английский

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Searching for new antifungals for the treatment of cryptococcosis

Revista da Sociedade Brasileira de Medicina Tropical, Год журнала: 2023, Номер 56

Опубликована: Янв. 1, 2023

There is a consensus that the antifungal repertoire for treatment of cryptococcal infections limited. Standard involves administration an drug derived from natural sources (i.e., amphotericin B) and two other drugs developed synthetically flucytosine fluconazole). Despite treatment, mortality rates associated with fungal cryptococcosis are high. Amphotericin B toxic, require intravenous administration, usually unavailable in low-income countries because their high cost. However, fluconazole cost-effective, widely available, harmless regard to its side effects. fungistatic agent has contributed considerably increase resistance frequent relapses patients meningitis. Therefore, there unquestionable need identify new alternatives or adjuvants conventional cryptococcosis. A potential should be able kill cryptococci "bypass" virulence mechanism yeast. Furthermore, it have fungicidal action, low toxicity, selectivity, easily penetrate central nervous system, available. In this review, we describe cryptococcosis, therapy, failures arising use traditionally considered reference standard. Additionally, present approaches used discovery counteract ranging screening products inclusion structural modifications optimize anticryptococcal activity, as well repositioning combined therapies.

Язык: Английский

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β-Lactams from the Ocean

Marine Drugs, Год журнала: 2023, Номер 21(2), С. 86 - 86

Опубликована: Янв. 25, 2023

The title of this essay is as much a question it statement. discovery the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites terrestrial fungi bacteria, transformed modern medicine. antibiotic β-lactams inactivate essential enzymes bacterial cell-wall biosynthesis. Moreover, ability to function enzyme inhibitors such great medical value, that which degrade hydrolytically β-lactams, β-lactamases, have equal value. Given privileged status for ring, therefore disappointment exemplification ring in marine sparse. It may be biologically active are there, simply yet encountered. In report, we posit second explanation: value secure an ecological advantage environment might compromised by its close structural similarity β-lactones quorum sensing. steric reactivity similarities between represent outside-of-the-box opportunity correlating new structures targets compelling biological activities.

Язык: Английский

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