The American Journal of Chinese Medicine,
Год журнала:
2023,
Номер
51(07), С. 1795 - 1821
Опубликована: Янв. 1, 2023
Fungi
play
an
important
role
in
the
solution
to
global
problems.
Making
use
of
processes
and
goods
that
are
based
on
fungi
can
help
promote
sustainability
by
making
most
efficient
natural
resources.
stand
apart
from
other
organisms
due
their
extraordinary
capacity
generate
organic
compounds.
They
necessary
for
psychological
physiological
well-being
people
worldwide.
excellent
producers
vitamins,
pigments,
hydrolytic
enzymes,
biofuels,
acids,
polysaccharides,
secondary
metabolites
such
as
antibiotics,
anticancer
treatments,
hypocholesterolemic
pharmaceuticals,
immunosuppressants.
Other
include
biofuels.
In
addition,
polysaccharides
produced
them.
We
provide
a
condensed
explanation
significance
variety
industries,
pharmaceutical
industry,
food
textile
transportation
industry.
addition
providing
better
understanding
biosynthetic
regulation
possibilities
genetic
engineering,
improved
laboratory
selection
nontoxigenic
fungal
strains
have
permitted
manufacture
larger
quantities
safe
commercial
items.
The
industrial
settings
is
topic
will
be
investigated
this
review.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Дек. 6, 2022
The
potential
of
edible
mushrooms
as
an
unexploited
treasure
trove,
although
rarely
included
in
known
food
guidelines,
is
highlighted.
Their
role
shielding
people
against
the
side
effects
unhealthy
stylish
diet
reviewed.
Mushrooms
complement
human
with
various
bioactive
molecules
not
identified
or
deficient
foodstuffs
plant
and
animal
sources,
being
considered
a
functional
for
prevention
several
diseases.
have
been
widely
used
medicinal
products
more
than
2,000
years,
but
globally
field
use
wild
has
untapped.
There
broad
range
which
remain
poorly
even
unreported
valuable
pool
sources
compounds
biopharma
utilization
new
dietary
supplements.
Some
unique
elements
their
preventative
healthcare
are
emphasized,
through
positive
impact
on
immune
system.
antiviral,
anti-inflammatory,
anti-neoplastic,
other
health
concerns
discussed.
incorporate
top
non-digestible
oligosaccharides,
ergothioneine,
humans
unable
to
synthesize,
later
antioxidant,
cytoprotective,
anti-inflammatory
element,
therapeutic
potential,
approved
by
world
agencies.
prebiotic
activity
beneficially
affects
gut
homeostasis
performance
balance
microbiota
enhanced.
Several
recent
studies
neurological
contribution
growth
nerve
brain
cells
mentioned.
Indeed,
foods'
nutraceuticals
presently
regarded
next-generation
foods,
supporting
wellness,
promising
prophylactic
agents.
Journal of Fungi,
Год журнала:
2023,
Номер
9(1), С. 73 - 73
Опубликована: Янв. 3, 2023
It
is
expected
that
the
world
population
will
reach
9
billion
by
2050.
Thus,
meat,
dairy
or
plant-based
protein
sources
fail
to
meet
global
demand.
New
solutions
must
be
offered
find
innovative
and
alternative
sources.
As
a
natural
gift,
edible
wild
mushrooms
growing
in
wet
shadow
places
can
picked
hand
have
been
used
as
food.
From
searching
forests
producing
single
cell
proteins
(SCP)
small
scales
mega
production,
academia,
United
Nations
Organizations,
industries,
political
makers
others,
play
significant
roles.
Fermented
traditional
foods
also
reinvestigated.
For
example,
kefir,
miso,
tempeh,
are
an
excellent
source
for
fungal
isolates
production.
Fungi
unique
criteria
of
consuming
various
inexpensive
wastes
carbon
energy
biomass,
concentrate
amino
acids
with
minimal
requirement
other
environmental
resources
(e.g.,
light
water).
Fungal
fermented
SCP
consumed
either
intentionally
unintentionally
our
daily
meals
many
applications
food
feed
industries.
This
review
addresses
fungi
animal
feed,
focusing
mainly
on
SCP,
mushrooms,
foods,
safety
their
consumption.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 11, 2023
Endophytic
fungi
comprise
host-associated
fungal
communities
which
thrive
within
the
tissues
of
host
plants
and
produce
a
diverse
range
secondary
metabolites
with
various
bioactive
attributes.
The
such
as
phenols,
polyketides,
saponins,
alkaloids
help
to
mitigate
biotic
abiotic
stresses,
fight
against
pathogen
attacks
enhance
plant
immune
system.
We
present
an
overview
association
endophytic
discuss
molecular
mechanisms
induced
during
their
symbiotic
interaction.
focuses
on
(especially
those
terpenoid
nature)
secreted
by
respective
function.
recent
advancement
in
multi-omics
approaches
paved
way
for
identification
these
characterization
via
comparative
analysis
extensive
omics
datasets.
This
study
also
elaborates
role
associated
key
agricultural
crops
hence
important
sustainability
agriculture.
Journal of Fungi,
Год журнала:
2023,
Номер
9(6), С. 688 - 688
Опубликована: Июнь 19, 2023
Fungi
play
many
roles
in
different
ecosystems.
The
precise
identification
of
fungi
is
important
aspects.
Historically,
they
were
identified
based
on
morphological
characteristics,
but
technological
advancements
such
as
polymerase
chain
reaction
(PCR)
and
DNA
sequencing
now
enable
more
accurate
taxonomy,
higher-level
classifications.
However,
some
species,
referred
to
"dark
taxa",
lack
distinct
physical
features
that
makes
their
challenging.
High-throughput
metagenomics
environmental
samples
provide
a
solution
identifying
new
lineages
fungi.
This
paper
discusses
approaches
including
PCR
amplification
rDNA,
multi-loci
phylogenetic
analyses,
the
importance
various
omics
(large-scale
molecular)
techniques
for
understanding
fungal
applications.
use
proteomics,
transcriptomics,
metatranscriptomics,
metabolomics,
interactomics
provides
comprehensive
These
advanced
technologies
are
critical
expanding
knowledge
Kingdom
Fungi,
its
impact
food
safety
security,
edible
mushrooms
foodomics,
secondary
metabolites,
mycotoxin-producing
fungi,
biomedical
therapeutic
applications,
antifungal
drugs
drug
resistance,
data
novel
development.
also
highlights
exploring
from
extreme
environments
understudied
areas
identify
dark
taxa.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(9), С. 1200 - 1200
Опубликована: Авг. 23, 2023
The
phenomenon
of
drug
resistance
in
micro-organisms
necessitates
the
search
for
new
compounds
capable
combating
them.
Fungi
emerge
as
a
promising
source
such
they
produce
wide
range
secondary
metabolites
with
bacteriostatic
or
fungistatic
activity.
These
can
serve
alternatives
commonly
used
antibiotics.
Furthermore,
fungi
also
accumulate
antiviral
This
review
focuses
on
filamentous
and
macrofungi
sources
antimicrobial
compounds.
article
describes
both
individual
isolated
extracts
that
exhibit
antibacterial,
antifungal,
are
produced
by
fruiting
bodies
mycelium,
well
biomass
mycelial
cultures.
Additionally,
this
characterizes
chemical
extracted
from
mushrooms
realm
cosmetology;
specifically,
their
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 258 - 258
Опубликована: Янв. 15, 2024
Sickle
cell
disease
(SCD),
a
distinctive
and
often
overlooked
illness
in
the
21st
century,
is
congenital
blood
disorder
characterized
by
considerable
phenotypic
diversity.
It
comprises
group
of
disorders,
with
sickle
anemia
(SCA)
being
most
prevalent
serious
genotype.
Although
there
have
been
some
systematic
reviews
global
data,
worldwide
statistics
regarding
SCD
prevalence,
morbidity,
mortality
remain
scarce.
In
developed
countries
lower
number
patients,
cutting-edge
technologies
led
to
development
new
treatments.
However,
developing
settings
where
(SCD)
more
prevalent,
medical
management,
rather
than
cure,
still
relies
on
use
hydroxyurea,
transfusions,
analgesics.
This
that
affects
red
cells,
consequently
affecting
organs
diverse
manners.
We
discuss
its
etiology
advent
technologies,
but
aim
this
study
understand
various
types
nutrition-related
studies
involving
individuals
suffering
from
SCD,
particularly
Africa.
The
interplay
environment,
food,
gut
microbiota,
along
their
respective
genomes
collectively
known
as
microbiome,
host
metabolism
responsible
for
mediating
metabolic
phenotypes
modulating
microbiota.
addition,
it
serves
purpose
providing
essential
nutrients.
Moreover,
engages
direct
interactions
homeostasis
immune
system,
well
indirect
via
metabolites.
Nutrition
interventions
nutritional
care
are
mechanisms
addressing
increased
nutrient
expenditures
important
aspects
supportive
management
patients
SCD.
Underprivileged
areas
Sub-Saharan
Africa
should
be
accompanied
efforts
define
promote
Their
importance
key
maintaining
well-being
quality
life,
especially
because
products
limited,
while
native
medicinal
plant
resources
acknowledged.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Март 13, 2024
In
recent
years,
there
has
been
a
considerable
rise
in
the
production
of
novel
metabolites
derived
from
fungi
compared
to
ones
originating
bacteria.
These
organic
substances
are
utilized
various
sectors
such
as
farming,
healthcare,
and
pharmaceutical.
Since
all
dividing
living
cells
contain
primary
metabolites,
secondary
synthesized
by
utilizing
intermediate
compounds
or
by-products
generated
metabolic
pathways.
Secondary
not
critical
for
growth
development
an
organism;
however,
they
exhibit
variety
distinct
biological
characteristics.
White-rot
only
microorganisms
able
decompose
wood
components.
Hence,
play
important
role
both
carbon
nitrogen
cycles
decomposing
non-living
substrates.
They
ubiquitous
nature,
particularly
hardwood
(e.g.,
birch
aspen)
forests.
fungi,
besides
ligninolytic
enzymes,
produce
different
bioactive
during
their
metabolism
including
some
with
antimicrobial
anticancer
properties.
Such
properties
could
be
potential
interest
pharmaceutical
industries.
Considering
importance
untapped
biologically
active
white-rot
present
paper
reviews
produced
interesting
bioactivities.
Current Issues in Molecular Biology,
Год журнала:
2023,
Номер
45(5), С. 3733 - 3756
Опубликована: Апрель 24, 2023
Rhizospheric
soil
is
the
richest
niche
of
different
microbes
that
produce
biologically
active
metabolites.
The
current
study
investigated
antimicrobial,
antifungal
and
anticancer
activities
ethyl
acetate
extract
potent
rhizospheric
fungus
Aspergillus
niger
AK6
(AK-6).
A
total
six
fungal
isolates
were
isolated,
isolate
AK-6
was
selected
based
on
primary
screening.
Further,
it
exhibited
moderate
antimicrobial
activity
against
pathogens
such
as
Klebsiella
pneumonia,
Candida
albicans,
Escherichia
coli,
Shigella
flexneri,
Bacillus
subtilis
Staphylococcus
aureus.
morphological
molecular
characterization
(18S
rRNA)
confirmed
belonged
to
niger.
showed
with
47.2%,
59.4%
64.1%
inhibition
Sclerotium
rolfsii,
Cercospora
canescens
Fusarium
sambucinum
phytopathogens.
FT-IR
analysis
displayed
biological
functional
groups.
Consequently,
GC-MS
bioactive
compounds,
namely,
n-didehydrohexacarboxyl-2,4,5-trimethylpiperazine
(23.82%),
dibutyl
phthalate
(14.65%),
e-5-heptadecanol
(8.98%),
2,4-ditert-butylphenol
(8.60%),
among
15
compounds
isolated.
MCF-7
cell
line
human
breast
adenocarcinoma
an
IC50
value
102.01
μg/mL.
Furthermore,
flow
cytometry
depicted
17.3%,
26.43%,
3.16%
early
late
apoptosis
necrosis
in
extarct
treated
line,
respectively.
results
present
suggest
isolated
strain
has
potential
be
explored
a
promising
drug
for
medical
agricultural
applications.