A Versatile Theranostic Nanoplatform with Aggregation‐Induced Emission Properties: Fluorescence Monitoring, Cellular Organelle Targeting, and Image‐Guided Photodynamic Therapy

Small, Год журнала: 2023, Номер 19(21)

Опубликована: Фев. 17, 2023

Abstract Photosensitizers (PSs) play a key role in the photodynamic therapy (PDT) of tumors. However, commonly used PSs are prone to intrinsic fluorescence aggregation‐caused quenching and photobleaching; this drawback severely limits clinical application PDT, necessitating new phototheranostic agents. Herein, multifunctional theranostic nanoplatform (named TTCBTA NP) is designed constructed achieve monitoring, lysosome‐specific targeting, image‐guided PDT. with twisted conformation D‐A structure encapsulated amphiphilic Pluronic F127 form nanoparticles (NPs) ultrapure water. The NPs exhibit biocompatibility, high stability, strong near‐infrared emission, desirable reactive oxygen species (ROSs) production capacity. also show high‐efficiency photo‐damage, negligible dark toxicity, excellent fluorescent tracing, accumulation lysosome for tumor cells. Furthermore, obtain images good resolution MCF‐7 tumors xenografted BALB/c nude mice. Crucially, present ablation ability PDT effect by generating abundant ROSs upon laser irradiation. These results demonstrate that NP may enable highly efficient

Язык: Английский

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Therapeutic potential of tumor treating fields for malignant brain tumors

Cancer Reports, Год журнала: 2023, Номер 6(5)

Опубликована: Март 29, 2023

Abstract Background Malignant brain tumors are among the most threatening diseases of central nervous system, and despite increasingly updated treatments, prognosis has not been improved. Tumor treating fields (TTFields) an emerging approach in cancer treatment using intermediate‐frequency low‐intensity electric field can lead to development novel therapeutic options. Recent Findings A series biological processes induced by TTFields exert anti‐cancer effects have identified. studies shown that alter bioelectrical state macromolecules organelles involved biology. Massive alterations cell proteomics transcriptomics caused were related as well multiple organelle structures activities. This review addresses mechanisms recent advances application therapy malignant tumors, especially glioblastoma (GBM). Conclusions As a strategy, promising results many clinical trials, GBM, continue evolve. growing number patients with being enrolled ongoing demonstrating TTFields‐based combination therapies improve outcomes.

Язык: Английский

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MPGAN: Multi Pareto Generative Adversarial Network for the denoising and quantitative analysis of low-dose PET images of human brain

Medical Image Analysis, Год журнала: 2024, Номер 98, С. 103306 - 103306

Опубликована: Авг. 17, 2024

Язык: Английский

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Spatial-temporal dynamic evolution of lewy body dementia by metabolic PET imaging

European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 52(1), С. 145 - 157

Опубликована: Авг. 19, 2024

Язык: Английский

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AI-driven antimicrobial peptides for drug development

Methods in microbiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

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