Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер unknown
Опубликована: Дек. 29, 2024
Язык: Английский
European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2023, Номер 50(7), С. 1848 - 1850
Опубликована: Март 6, 2023
Язык: Английский
Процитировано
14
Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 522 - 522
Опубликована: Апрель 3, 2025
Fibroblast activation protein (FAP) is a serine protease selectively expressed in cancer-associated fibroblasts (CAFs), fibrotic tissues, and areas of active tissue remodeling, making it an attractive target for diagnostic imaging across spectrum disease. FAP inhibitors (FAPIs) labeled with PET tracers have rapidly advanced as novel modality broad clinical applications that offers several advantages, including rapid tumor accumulation, low background uptake, high tumor-to-background ratios. In oncology, FAPI has demonstrated excellent performance visualizing wide range malignancies, those glycolytic activity, such pancreatic cancer, cholangiocarcinoma, certain sarcomas. Its sensitivity specificity the stromal component enables improved delineation, staging, response assessment. Additionally, potential to guide theranostic approaches, where same tracer can be therapeutic radionuclides, positions key player precision oncology. Beyond shown promise conditions characterized by inflammatory processes. cardiovascular field, being investigated its ability detect myocardial fibrosis cardiac crucial like heart failure, post-myocardial infarction hypertrophic cardiomyopathy. This review highlights expanding FAPI-based inflammation, While current data are promising, further large-scale studies multicenter trials essential validate these findings establish standardized protocols. The versatility applicability underscore transformative tool medicine.
Язык: Английский
Процитировано
0
European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 51(11), С. 3373 - 3385
Опубликована: Май 16, 2024
Язык: Английский
Процитировано
3
Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 716 - 716
Опубликована: Май 31, 2024
The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment non-oncological diseases, such as inflammatory and infectious even if evidence in literature still its initial phases. We conducted a systematic search Scopus, PubMed/MEDLINE, Embase, Cochrane library databases studies published before 31 December 2023 reporting disease imaging with FAPI PET/CT. included twenty-one total 1046 patients. most frequent studied was lung interstitial disease, investigated six 200 patients, followed by bone joint diseases two 185 IgG4-related 53 Crohn’s 30 Despite heterogeneity terms study design technical features, PET/CT showed high detection rate diagnostic role. Moreover, when compared 2-[18F]FDG (n = 7 studies), seems to have better performances. presence chronic inflammation tissue remodeling, typical immune-mediated conditions, may be underlying mechanism uptake.
Язык: Английский
Процитировано
3
European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 51(13), С. 4179 - 4180
Опубликована: Июль 2, 2024
Язык: Английский
Процитировано
2
Seminars in Nuclear Medicine, Год журнала: 2023, Номер unknown
Опубликована: Дек. 1, 2023
Язык: Английский
Процитировано
6
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Фев. 19, 2024
Background Total hip arthroplasty (THA) is a well-established surgical procedure that has been extensively validated to alleviate pain, enhance joint function, improve the ability perform daily activities, and overall quality of life. However, this associated with certain complications, among which skeletal muscle fibrosis frequently overlooked but significant complication can lead persistent pain. Currently, there no effective method for diagnosing following total arthroplasty. Case report We 75-year-old male patient who complained left groin pain after revision Serological examinations, X-rays, bone scan results were all normal. during 68 Ga-FAPI PET/CT examination, we observed radiotracer uptake along iliopsoas muscle. This abnormal pattern suggested potential biological activity in specific area. Combined physical was diagnosed fibrosis. Conclusions The presented images indicated an important indicator diagnosis, prospect fibroblast activation protein diagnosis shown application value.
Язык: Английский
Процитировано
1
Skeletal Radiology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Язык: Английский
Процитировано
1
Antibiotics, Год журнала: 2024, Номер 13(4), С. 351 - 351
Опубликована: Апрель 11, 2024
The rising number of arthroplasties is combined with a periprosthetic joint infections, which leads to life-concerning consequences for the patients, including extended antibiotic treatment, further surgery and increased mortality. heterogeneity symptoms inflammatory response patients due to, e.g., age comorbidities absence single diagnostic test 100% accuracy make it very challenging choose right parameters confirm or deny infection establish standardized definition. In recent years, additional possibilities have emerged primarily through increasing availability new methods, such as genetic techniques. aim review provide an overview current state knowledge about various tests, latest developments. combination different tests increases diagnosis. Each physician clinical department must select from available methods that can be best implemented them in organizational technical terms. Serological cultivation samples aspiration biopsy should synovial create accurate figure failure prosthesis, while imaging procedures are used obtain information planned therapeutic procedure.
Язык: Английский
Процитировано
0
EJNMMI Research, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 2, 2024
Язык: Английский
Процитировано
0