Interdisciplinary cancer research, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Trends in Molecular Medicine, Год журнала: 2024, Номер 30(9), С. 875 - 889
Опубликована: Июль 10, 2024
Endometriosis is a common disorder associated with pain, gastrointestinal and urinary symptoms, infertility, fatigue. It defined by the presence of endometrial-like lesions found predominantly in pelvis. Mechanisms that contribute to disease aetiology include changes hormonal, inflammatory, pain pathways. In this article, we focus on recent developments imaging technologies, our improved understanding mechanisms contributing drug therapies are clinical trials, insights from studies gut offer potential support self-management strategies. We postulate improvements quality life patients will be accelerated reframing endometriosis as multi-system learning treatments targeting symptoms shared between endometriosis, neuroinflammatory, disorders.
Язык: Английский
Процитировано
11
EJNMMI Radiopharmacy and Chemistry, Год журнала: 2024, Номер 9(1)
Опубликована: Май 2, 2024
Abstract Background In recent years, fibroblast activating protein (FAP), a biomarker overexpressed by cancer-associated fibroblasts, has emerged as one of the most promising biomarkers in oncology. Similarly, FAP overexpression been detected various fibroblast-mediated inflammatory conditions such liver cirrhosis and idiopathic pulmonary fibrosis. Along this trajectory, FAP-targeted positron emission tomography (PET), utilizing inhibitors (FAPi) labeled with emitters, gained traction powerful imaging approach both cancer inflammation. However, PET represents high-cost technology, its widespread adoption is still limited compared to availability gamma cameras. To address issue, several efforts have made explore potential [ 99m Tc]Tc-FAPi tracers molecular probes for cameras single photon computed (SPECT). Main body Several approaches investigated labeling FAPi-based compounds Tc. Specifically, mono-oxo, tricarbonyl, isonitrile, HYNIC strategies applied produce tracers, which tested vitro animal models. Overall, these demonstrated high efficiency strong binding. The resulting shown specificity FAP-positive cells xenografts model studies, respectively. majority exhibited variable levels lipophilicity, leading preferential excretion through hepatobiliary route undesirable binding lipoproteins. Consequently, synthesize more hydrophilic improve pharmacokinetic properties achieve favorable biodistribution, particularly abdominal region. SPECT yielded results patients gastrointestinal tumors, demonstrating comparable or superior diagnostic performance other modalities. encouraging outcomes observed subjects gliomas, lung cancer, breast cervical cancer. Beyond oncological applications, Tc]Tc-FAPi-based successfully employed myocardial Conclusions This overview focuses on radiochemical obtaining highlighting main challenges encountered possible solutions when applying each distinct approach. Additionally, it covers preclinical initial clinical applications
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 10136 - 10136
Опубликована: Июнь 14, 2023
Various papers have introduced the use of positron emission tomography (PET) with [68Ga]Ga-radiolabeled fibroblast-activation protein inhibitor (FAPi) radiopharmaceuticals in different subtypes gastric cancer (GC). Our aim was to assess diagnostic performance this novel molecular imaging technique GC a systematic review and meta-analysis. A straightforward literature search concerning FAP-targeted PET performed. Original articles evaluating examination both newly diagnosed patients disease relapse were included. The included nine original studies, eight them also eligible for quantitative synthesis provided pooled detection rates 95% 97% assessment primary tumor distant metastases, respectively, sensitivity specificity 74% 89%, regional lymph node metastases. Significant statistical heterogeneity among studies found only analysis rate (I2 = 64%). Conclusions: Beyond limitations meta-analysis (i.e., all conducted Asia, using [18F]FDG PET/CT as comparator index test), data demonstrate promising GC. Nevertheless, more prospective multicentric are needed confirm excellent performances cluster patients.
Язык: Английский
Процитировано
10
European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 51(11), С. 3373 - 3385
Опубликована: Май 16, 2024
Язык: Английский
Процитировано
3
Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 716 - 716
Опубликована: Май 31, 2024
The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment non-oncological diseases, such as inflammatory and infectious even if evidence in literature still its initial phases. We conducted a systematic search Scopus, PubMed/MEDLINE, Embase, Cochrane library databases studies published before 31 December 2023 reporting disease imaging with FAPI PET/CT. included twenty-one total 1046 patients. most frequent studied was lung interstitial disease, investigated six 200 patients, followed by bone joint diseases two 185 IgG4-related 53 Crohn’s 30 Despite heterogeneity terms study design technical features, PET/CT showed high detection rate diagnostic role. Moreover, when compared 2-[18F]FDG (n = 7 studies), seems to have better performances. presence chronic inflammation tissue remodeling, typical immune-mediated conditions, may be underlying mechanism uptake.
Язык: Английский
Процитировано
3
Pharmaceuticals, Год журнала: 2023, Номер 16(12), С. 1664 - 1664
Опубликована: Ноя. 30, 2023
Several studies have examined the use of positron emission tomography (PET) using [68Ga]Ga-radiolabeled fibroblast-activation protein inhibitors (FAPi) across multiple subtypes head and neck cancer (HNC). The purpose present study was to evaluate diagnostic accuracy a newly developed molecular imaging approach in context HNC through comprehensive review meta-analysis. A thorough literature conducted identify scholarly articles about effectiveness FAP-targeted PET imaging. incorporates original publications assessing efficacy this innovative test both diagnosed previously treated patients. This systematic eleven investigations, which nine were deemed suitable for inclusion subsequent quantitative synthesis yielded pooled detection rate 99% primary lesions. Additionally, on per patient-based analysis, sensitivity specificity regional lymph node metastases found be 90% 84%, respectively. analysis revealed statistical heterogeneity among findings presented indicate favorable performance detecting tumors. In contrast, discordant results concerning found. However, further multicentric trials are required validate specific group
Язык: Английский
Процитировано
7
World Journal of Nuclear Medicine, Год журнала: 2024, Номер 23(02), С. 071 - 072
Опубликована: Июнь 1, 2024
Positron emission tomography (PET) imaging, utilizing fluorodeoxyglucose (FDG) as a primary radiotracer, has significantly advanced the field of nuclear oncology. However, its effectiveness is hampered by limitations such limited specificity and insufficient sensitivity for certain types tumors.[1] This challenge propelled search novel molecular probes to enhance or complement FDG in cancer management, particularly amidst advancements precision oncology rising rates occurrence mortality. Recent statistics from Global Cancer Observatory 2020 reported an alarming figure approximately 19.3 million new cases 10 cancer-related deaths worldwide.[2] These findings underscore urgent need more effective diagnostic tools battle against cancer.
Язык: Английский
Процитировано
2
Frontiers in Nuclear Medicine, Год журнала: 2024, Номер 4
Опубликована: Апрель 11, 2024
EDITORIAL article Front. Nucl. Med., 11 April 2024Sec. Radionuclide Therapy Volume 4 - 2024 | https://doi.org/10.3389/fnume.2024.1385097
Язык: Английский
Процитировано
1
Frontiers in Chemistry, Год журнала: 2024, Номер 12
Опубликована: Июль 15, 2024
Gallium-68-labeled FAPI-46 has recently been proposed as a novel positron emission tomography imaging probe to diagnose and monitor wide variety of cancers. Promising results from several ongoing clinical trials have led soaring demand for this radiotracer. Typical [
Язык: Английский
Процитировано
1
European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 27, 2024
Язык: Английский
Процитировано
1