bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
After
infection
with
SARS-CoV-2,
patients
may
present
one
or
more
symptoms
that
appear
persist
over
time,
including
fatigue,
respiratory,
cardiovascular
and
neurological
disorders.
Neurological
include
anxiety,
depression
impaired
short-term
memory.
However,
the
exact
underlying
mechanisms
of
long
Covid
are
not
yet
decrypted.
Using
golden
hamster
as
a
model,
we
provide
further
evidence
SARS-CoV-2
is
neuroinvasive
can
in
central
nervous
system,
found
viral
RNA
replicative
virus
brainstem
after
80
days
infection.
Infected
hamsters
presented
neurodegenerative
signature
brainstem,
overexpression
innate
immunity
genes,
impacted
dopaminergic
glutamatergic
synapses,
altered
energy
metabolism.
Finally,
infected
manifested
persistent
signs
memory,
well
late-onset
valuable
model
to
study
Covid.
Conclusively,
virus-related
immunometabolic
coexist
contribute
manifestation
neuropsychiatric
cognitive
symptoms.
Highlights
infects
persists
intranasally-inoculated
Persistent
consequences
observed
SARS-CoV-2-infected
The
distinct
transcriptome
profiles
acute
systems
affected
affects
expression
genes
related
processes
A
hypometabolic
brain
pattern
has
been
reported
in
patients
with
post-COVID
condition
(PCC).
The
aim
of
this
study
was
to
investigate
reorganization
metabolic
connectivity
PCC.
One
hundred
eighty-eight
who
underwent
18F-FDG
PET
for
PCC
were
retrospectively
included
from
two
university
hospital
centres.
These
age-
and
sex-matched
120
healthy
controls
before
the
COVID-19
outbreak.
voxel-based
group
comparison
between
performed
(p-voxel
at
0.005
uncorrected,
p-cluster
0.05
FWE
corrected).
Interregional
correlation
analyses
identified
clusters
as
well
sparse
inverse
covariance
estimations
whole-brain
scaling
also
conducted.
Both
level
all
then
secondarily
according
postinfection
delay;
88
100
patients,
respectively,
had
a
delay
less
than
or
greater
9
months
(±
M).
Three
clusters,
namely,
right
frontotemporal,
left
cerebellar,
comparisons
patients.
Within
pattern,
modification
observed
compared
controls,
which
more
marked
+
M
-
group.
On
other
hand,
graph
analysis
revealed
decrease
efficiency
metrics
Metabolic
is
modified
within
post-COVID-19
network,
lasting
evolving
over
time,
suggesting
functional
adaptation.
Abstract
Coronavirus
disease
2019
(COVID‐19),
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2),
has
infected
over
770
million
people
worldwide.
The
long‐term
effects
of
COVID‐19
and
their
management
have
become
important
issues.
Accumulating
evidence
indicates
that
post‐COVID‐19
syndrome,
also
known
as
long
COVID,
is
not
limited
to
symptoms
but
affects
a
wide
range
systems,
including
neurological,
cardiovascular,
gastrointestinal,
musculoskeletal,
reproductive
systems
etc.
social
economic
losses
associated
with
these
are
estimated
reach
3·7
trillion
dollars
in
the
United
States
alone.
However,
no
treatment
for
COVID
been
developed.
Herein,
literature
on
comprehensively
reviewed
examine
underlying
causes.
Additionally,
supporting
efficacy
nanoengineered
niclosamide
presented,
given
its
ability
counteract
Niclosamide
already
Food
Drug
Administration
(FDA)‐approved,
one
viable
candidate
clinical
trials
COVID.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Июнь 3, 2025
Post-acute
infection
syndromes
(PAIS),
i.e.,
long-lasting
pathologies
subsequent
to
infections
that
do
not
properly
resolve,
have
both
a
common
core
and
broad
diversity
of
manifestations.
PAIS
include
group
symptoms
(pathological
fatigue,
cognitive
problems,
sleep
disorders
pain)
accompanied
by
large
set
diverse
symptoms.
Core
additional
symptoms,
which
can
persist
for
years,
exhibiting
periods
relapses
remissions,
usually
start
suddenly
after
an
apparently
infection.
display
highly
variable
clinical
features
depending
on
the
nature
initial
pathogen,
even
larger
extent,
preexisting
individual
terrains
in
are
rooted.
In
first
part,
I
discuss
biological
issues
related
persistence
microbial
antigens,
dysregulated
immune
responses,
reactivation
latent
viruses,
different
potential
self-sustained
inflammatory
loops,
mitochondrial
dysfunction,
metabolic
tryptophan-
kynurenin
pathway
(TKP)
with
impact
serotonin,
consequences
dysfunctional
bidirectional
microbiota-gut-brain
axis.
The
second
part
deals
nervous
system
dependence
PAIS.
rely
concept
interoception,
process
brain
senses,
integrates
interprets
signals
originating
from
within
body,
sends
feebacks
aimed
at
maintaining
homeostasis.
Interoception
is
central
understanding
origin
dysautonomia,
dysfunctioning
hypothalamus-pituitary-adrenal
(HPA)
axis,
its
relation
stress,
inflammation
or
depression.
propose
all
predispositions
leading
vicious
circles
constitute
building
blocks
self-assemble
many
possible
ways,
give
rise
A
useful
discrimination
between
subtypes
should
be
obtained
composite
profiling
including
biomarkers,
questionnaires
functional
tests
so
as
take
into
account
multidimensionality.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 25, 2024
Many
patients
experience
persistent
symptoms
after
COVID-19,
a
syndrome
referred
to
as
Long
COVID
(LC).
The
goal
of
this
study
was
identify
novel
new
or
worsening
comorbidities
self-reported
in
with
LC.
