bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
After
infection
with
SARS-CoV-2,
patients
may
present
one
or
more
symptoms
that
appear
persist
over
time,
including
fatigue,
respiratory,
cardiovascular
and
neurological
disorders.
Neurological
include
anxiety,
depression
impaired
short-term
memory.
However,
the
exact
underlying
mechanisms
of
long
Covid
are
not
yet
decrypted.
Using
golden
hamster
as
a
model,
we
provide
further
evidence
SARS-CoV-2
is
neuroinvasive
can
in
central
nervous
system,
found
viral
RNA
replicative
virus
brainstem
after
80
days
infection.
Infected
hamsters
presented
neurodegenerative
signature
brainstem,
overexpression
innate
immunity
genes,
impacted
dopaminergic
glutamatergic
synapses,
altered
energy
metabolism.
Finally,
infected
manifested
persistent
signs
memory,
well
late-onset
valuable
model
to
study
Covid.
Conclusively,
virus-related
immunometabolic
coexist
contribute
manifestation
neuropsychiatric
cognitive
symptoms.
Highlights
infects
persists
intranasally-inoculated
Persistent
consequences
observed
SARS-CoV-2-infected
The
distinct
transcriptome
profiles
acute
systems
affected
affects
expression
genes
related
processes
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
Abstract
Coronavirus
disease
2019
(COVID‐19),
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2),
has
infected
over
770
million
people
worldwide.
The
long‐term
effects
of
COVID‐19
and
their
management
have
become
important
issues.
Accumulating
evidence
indicates
that
post‐COVID‐19
syndrome,
also
known
as
long
COVID,
is
not
limited
to
symptoms
but
affects
a
wide
range
systems,
including
neurological,
cardiovascular,
gastrointestinal,
musculoskeletal,
reproductive
systems
etc.
social
economic
losses
associated
with
these
are
estimated
reach
3·7
trillion
dollars
in
the
United
States
alone.
However,
no
treatment
for
COVID
been
developed.
Herein,
literature
on
comprehensively
reviewed
examine
underlying
causes.
Additionally,
supporting
efficacy
nanoengineered
niclosamide
presented,
given
its
ability
counteract
Niclosamide
already
Food
Drug
Administration
(FDA)‐approved,
one
viable
candidate
clinical
trials
COVID.
EJNMMI Research,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 30, 2025
A
hypometabolic
brain
pattern
has
been
reported
in
patients
with
post-COVID
condition
(PCC).
The
aim
of
this
study
was
to
investigate
reorganization
metabolic
connectivity
PCC.
One
hundred
eighty-eight
who
underwent
18F-FDG
PET
for
PCC
were
retrospectively
included
from
two
university
hospital
centres.
These
age-
and
sex-matched
120
healthy
controls
before
the
COVID-19
outbreak.
voxel-based
group
comparison
between
performed
(p-voxel
at
0.005
uncorrected,
p-cluster
0.05
FWE
corrected).
Interregional
correlation
analyses
identified
clusters
as
well
sparse
inverse
covariance
estimations
whole-brain
scaling
also
conducted.
Both
level
all
then
secondarily
according
postinfection
delay;
88
100
patients,
respectively,
had
a
delay
less
than
or
greater
9
months
(±
M).
Three
clusters,
namely,
right
frontotemporal,
left
cerebellar,
comparisons
patients.
Within
pattern,
modification
observed
compared
controls,
which
more
marked
+
M
-
group.
On
other
hand,
graph
analysis
revealed
decrease
efficiency
metrics
Metabolic
is
modified
within
post-COVID-19
network,
lasting
evolving
over
time,
suggesting
functional
adaptation.
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 25, 2024
Many
patients
experience
persistent
symptoms
after
COVID-19,
a
syndrome
referred
to
as
Long
COVID
(LC).
The
goal
of
this
study
was
identify
novel
new
or
worsening
comorbidities
self-reported
in
with
LC.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
Abstract
Background.
A
hypometabolic
brain
pattern
has
been
reported
in
patients
with
post-COVID
condition.
The
aim
of
this
study
was
to
investigate
reorganization
metabolic
connectivity
condition
(PCC).
Results.
One
hundred
eighty-eight
who
underwent
18F-FDG
PET
for
PCC
were
retrospectively
included
from
two
university
hospital
centres.
These
age-
and
sex-matched
120
healthy
controls
before
the
COVID-19
outbreak.
voxel-based
group
comparison
between
performed
(p-voxel
at
0.005
uncorrected,
p-cluster
0.05
FWE
corrected).
Interregional
correlation
analyses
(IRCA)
identified
clusters
as
well
sparse
inverse
covariance
estimations
(SICEs)
whole-brain
scaling
also
conducted.
Both
level
all
then
secondarily
according
postinfection
delay;
88
100
patients,
respectively,
had
a
delay
less
than
or
greater
9
months
(±
M).
Three
clusters,
namely,
right
frontotemporal,
left
cerebellar,
comparisons
patients.
Within
pattern,
modification
observed
compared
controls,
which
more
marked
+
M
−
group.
On
other
hand,
graph
analysis
revealed
decrease
efficiency
metrics
PCC.
Conclusions.
Metabolic
is
modified
within
post-COVID-19
network,
lasting
evolving
over
time,
suggesting
functional
adaptation.
