Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 10, 2024
Ferroptosis
is
an
iron-dependent
form
of
regulated
cell
death
characterized
by
glutathione
(GSH)
depletion,
peroxidase
4
(GPX4)
inactivation,
and
the
build-up
lipotoxic
reactive
species.
Ferroptosis-targeted
induction
a
promising
therapeutic
approach
for
addressing
antimalarial
drug
resistance.
In
addition
to
being
primary
source
intracellular
energy
supply
oxygen
species
(ROS)
generation,
mitochondria
actively
participate
in
diverse
forms
death,
including
ferroptosis.
Altered
mitochondrial
morphology
functionality
are
attributed
Diverse
mitochondria-related
proteins
metabolic
activities
have
been
implicated
fine-tuning
action
ferroptosis
inducers.
Herein,
we
review
recent
progress
this
evolving
field,
elucidating
numerous
mechanisms
which
regulate
giving
insight
into
role
organelle
Additionally,
present
overview
how
contribute
malaria.
Furthermore,
attempt
shed
light
on
inclusive
perspective
targeting
malaria
parasites'
mitochondrion
attacking
redox
homeostasis
anticipated
induce
ferroptosis-mediated
antiparasitic
effects.
Язык: Английский
Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116734 - 116734
Опубликована: Май 15, 2024
Spinal
cord
injury
(SCI)
is
a
type
of
central
nervous
system
(CNS)
in
which
ferroptosis
becoming
promising
target
for
treatment.
Alpha-tocopherol
(Vitamin
E,
Vit
E)
compound
with
anti-ferroptosis
activity.
The
mechanism
alpha-tocopherol
regulating
after
SCI
has
not
been
deeply
studied.
In
this
study,
rats
were
treated
by
based
on
bioinformatic
analysis
and
molecular
docking
prediction.
Behavioral
tests
histological
findings
showed
that
promoted
neural
function
recovery
tissue
repairment
SCI.
Subsequently,
regulatory
effects
Alox15
detected
then
localized
immunofluorescence.
vitro,
improved
the
ROS
accumulation,
iron
overload,
lipid
peroxidation
mitochondrial
dysfunction.
expression
Alox15,
Ptgs2
4Hne
validated
vitro.
Finally,
inhibitory
weakened
mutation
87th
residue
Alox15.
summary,
could
alleviate
SCI-induced
downregulating
to
promote
Findings
study
help
further
our
understanding
provide
novel
insight
treating
Язык: Английский
Targeting cell death mechanisms: the potential of autophagy and ferroptosis in hepatocellular carcinoma therapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 9, 2024
Ferroptosis
is
a
type
of
cell
death
that
plays
remarkable
role
in
the
growth
and
advancement
malignancies
including
hepatocellular
carcinoma
(HCC).
Non-coding
RNAs
(ncRNAs)
have
considerable
impact
on
HCC
by
functioning
as
either
oncogenes
or
suppressors.
Recent
research
has
demonstrated
non-coding
ability
to
control
ferroptosis
cells,
hence
impacting
tumors
resistance
these
cells
drugs.
Autophagy
mechanism
conserved
throughout
evolution
maintaining
balance
body
under
normal
settings.
Nevertheless,
occurrence
dysregulation
autophagy
evident
progression
various
human
disorders,
specifically
cancer.
dual
roles
cancer,
potentially
influencing
both
survival
death.
prevalent
kind
liver
genetic
mutations
changes
molecular
pathways
might
worsen
its
advancement.
The
subject
debate,
it
capacity
repress
promote
tumor
growth.
activation
can
apoptosis,
proliferation
glucose
metabolism,
facilitate
spread
through
EMT.
Inhibiting
hinder
enhance
respond
treatment.
regulated
several
signaling
pathways,
such
STAT3,
Wnt,
miRNAs,
lncRNAs,
circRNAs.
Utilizing
anticancer
drugs
target
may
advantageous
implications
for
efficacy
cancer
Язык: Английский
ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage
Environment International,
Год журнала:
2024,
Номер
190, С. 108897 - 108897
Опубликована: Июль 20, 2024
The
utilization
of
Cobalt
(Co)
has
surged
due
to
it
is
critical
role
in
renewable
energy
technologies
and
other
high-tech
applications.
Concurrently,
the
potential
health
risks
associated
with
Co
exposure
have
raised
concerns.
Previous
studies,
including
our
own,
shown
that
can
impair
learn
memory
functions
as
an
epigenetic
hazard,
even
at
low
concentrations.
In
this
study,
we
explore
mechanisms
Co-induced
ferroptosis
neurodegenerative
damage
both
vivo
vitro,
focusing
on
regulation
by
N6-methyladenosine
(m
Язык: Английский
Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2969 - 2969
Опубликована: Март 25, 2025
Photodynamic
therapy
(PDT)
is
an
innovative
treatment
that
has
recently
been
approved
for
clinical
use
and
holds
promise
cancer
patients.
It
offers
several
benefits,
such
as
low
systemic
toxicity,
minimal
invasiveness,
the
ability
to
stimulate
antitumor
immune
responses.
For
certain
types
of
cancer,
it
shown
positive
results
with
few
side
effects.
However,
PDT
still
faces
some
challenges,
including
limited
light
penetration
into
deeper
tumor
tissues,
uneven
distribution
photosensitizer
(PS)
can
also
affect
healthy
cells,
difficulties
posed
by
hypoxic
microenvironment
(TME).
In
conditions,
PDT's
effectiveness
reduced
due
insufficient
production
reactive
oxygen
species,
which
limits
destruction
lead
relapse.
This
review
highlights
recent
advances
in
photosensitizers
nanotechnologies
are
being
developed
improve
PDT.
focuses
on
multifunctional
nanoplatforms
nanoshuttles
have
preclinical
studies,
especially
treating
solid
tumors.
One
key
areas
focus
development
PSs
specifically
target
mitochondria
treat
deep-seated
malignant
New
mitochondria-targeting
nano-PSs
designed
better
water
solubility
extended
wavelength
ranges,
allowing
them
tumors
more
effectively,
even
challenging,
environments.
These
advancements
opening
new
doors
treatment,
when
combined
other
therapeutic
strategies.
Moving
forward,
research
should
optimizing
PDT,
creating
efficient
drug
delivery
systems,
developing
smarter
platforms.
Ultimately,
these
efforts
aim
make
a
first-choice
option
Язык: Английский
Exploration of the role of immune cells and cell therapy in hepatocellular carcinoma
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 16, 2025
Hepatocellular
carcinoma
stands
as
one
of
the
foremost
contributors
to
cancer-associated
fatalities
globally,
and
limitations
traditional
treatment
methods
have
prompted
researchers
explore
new
therapeutic
options.
Recently,
cell
therapy
has
emerged
a
promising
approach
for
HCC,
showing
significant
potential
in
improving
patient
outcomes.
This
review
article
explores
use
covering
different
types,
mechanisms
behind
their
effectiveness,
recent
advancements
clinical
trials,
ongoing
challenges.
aims
provide
insightful
perspectives
future
research
applications
treating
HCC
by
synthesizing
current
knowledge.
Язык: Английский
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
Cancer and Metastasis Reviews,
Год журнала:
2025,
Номер
44(2)
Опубликована: Апрель 29, 2025
Язык: Английский
Mitochondrial metabolism: A moving target in hepatocellular carcinoma therapy
Journal of Cellular Physiology,
Год журнала:
2024,
Номер
240(1)
Опубликована: Сен. 26, 2024
Abstract
Mitochondria
are
pivotal
contributors
to
cancer
mechanisms
due
their
homeostatic
and
pathological
roles
in
cellular
bioenergetics,
biosynthesis,
metabolism,
signaling,
survival.
During
transformation
tumor
initiation,
mitochondrial
function
is
often
disrupted
by
oncogenic
mutations,
leading
a
metabolic
profile
distinct
from
precursor
cells.
In
this
review,
we
focus
on
hepatocellular
carcinoma,
arising
metabolically
robust
nutrient
rich
hepatocytes,
discuss
the
mechanistic
impact
of
altered
metabolism
setting.
We
provide
distinctions
between
normal
activity
versus
disease‐related
which
yielded
therapeutic
opportunities,
along
with
highlighting
recent
preclinical
clinical
efforts
focused
targeting
metabolism.
Finally,
several
novel
strategies
for
exploiting
programs
eliminate
carcinoma
cells
metabolism‐specific
contexts
presented
integrate
these
concepts
gain
foresight
into
future
mitochondria‐focused
therapeutics.
Язык: Английский
Advances in Immune Checkpoint Therapy in Hepatocellular Carcinoma
British Journal of Hospital Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 21
Опубликована: Сен. 30, 2024
The
incidence
and
lethality
of
hepatocellular
carcinoma
(HCC)
are
increasing
annually,
traditional
treatments
have
been
proven
to
be
ineffective
for
patients
with
advanced
stages
the
disease.
In
recent
years,
immune
checkpoint
therapy
has
rapidly
evolved,
demonstrating
promising
results
across
a
wide
range
cancers
offering
new
hope
cancer
treatment.
However,
efficacy
in
HCC
varies
greatly
among
individuals,
only
small
proportion
responding
positively.
A
major
cause
resistance
poor
is
evasion,
which
often
due
insufficient
infiltration
cells.
Understanding
mechanisms
underlying
evasion
crucial
enhancing
therapies.
this
review,
we
aim
summarize
observed
during
discuss
future
directions
therapeutic
approach.
Our
goal
provide
insights
that
could
help
overcome
thereby
improving
therapies
extending
patient
survival
time.
Язык: Английский