Advances in Immune Checkpoint Therapy in Hepatocellular Carcinoma DOI

Yamei Huang,

Weiping Yu

British Journal of Hospital Medicine, Год журнала: 2024, Номер unknown, С. 1 - 21

Опубликована: Сен. 30, 2024

The incidence and lethality of hepatocellular carcinoma (HCC) are increasing annually, traditional treatments have been proven to be ineffective for patients with advanced stages the disease. In recent years, immune checkpoint therapy has rapidly evolved, demonstrating promising results across a wide range cancers offering new hope cancer treatment. However, efficacy in HCC varies greatly among individuals, only small proportion responding positively. A major cause resistance poor is evasion, which often due insufficient infiltration cells. Understanding mechanisms underlying evasion crucial enhancing therapies. this review, we aim summarize observed during discuss future directions therapeutic approach. Our goal provide insights that could help overcome thereby improving therapies extending patient survival time.

Язык: Английский

Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions DOI Creative Commons

Adegbolagun Grace Adegboro,

Israel Sunmola Afolabi

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Апрель 10, 2024

Ferroptosis is an iron-dependent form of regulated cell death characterized by glutathione (GSH) depletion, peroxidase 4 (GPX4) inactivation, and the build-up lipotoxic reactive species. Ferroptosis-targeted induction a promising therapeutic approach for addressing antimalarial drug resistance. In addition to being primary source intracellular energy supply oxygen species (ROS) generation, mitochondria actively participate in diverse forms death, including ferroptosis. Altered mitochondrial morphology functionality are attributed Diverse mitochondria-related proteins metabolic activities have been implicated fine-tuning action ferroptosis inducers. Herein, we review recent progress this evolving field, elucidating numerous mechanisms which regulate giving insight into role organelle Additionally, present overview how contribute malaria. Furthermore, attempt shed light on inclusive perspective targeting malaria parasites' mitochondrion attacking redox homeostasis anticipated induce ferroptosis-mediated antiparasitic effects.

Язык: Английский

Процитировано

8

Alpha-tocopherol inhibits ferroptosis and promotes neural function recovery in rats with spinal cord injury via downregulating Alox15 DOI Open Access
R. Zhu, Yu Kang,

Qiangwei Li

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116734 - 116734

Опубликована: Май 15, 2024

Spinal cord injury (SCI) is a type of central nervous system (CNS) in which ferroptosis becoming promising target for treatment. Alpha-tocopherol (Vitamin E, Vit E) compound with anti-ferroptosis activity. The mechanism alpha-tocopherol regulating after SCI has not been deeply studied. In this study, rats were treated by based on bioinformatic analysis and molecular docking prediction. Behavioral tests histological findings showed that promoted neural function recovery tissue repairment SCI. Subsequently, regulatory effects Alox15 detected then localized immunofluorescence. vitro, improved the ROS accumulation, iron overload, lipid peroxidation mitochondrial dysfunction. expression Alox15, Ptgs2 4Hne validated vitro. Finally, inhibitory weakened mutation 87th residue Alox15. summary, could alleviate SCI-induced downregulating to promote Findings study help further our understanding provide novel insight treating

Язык: Английский

Процитировано

7

Targeting cell death mechanisms: the potential of autophagy and ferroptosis in hepatocellular carcinoma therapy DOI Creative Commons
Beibei Liu,

Ling Liu,

Yang Liu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 9, 2024

Ferroptosis is a type of cell death that plays remarkable role in the growth and advancement malignancies including hepatocellular carcinoma (HCC). Non-coding RNAs (ncRNAs) have considerable impact on HCC by functioning as either oncogenes or suppressors. Recent research has demonstrated non-coding ability to control ferroptosis cells, hence impacting tumors resistance these cells drugs. Autophagy mechanism conserved throughout evolution maintaining balance body under normal settings. Nevertheless, occurrence dysregulation autophagy evident progression various human disorders, specifically cancer. dual roles cancer, potentially influencing both survival death. prevalent kind liver genetic mutations changes molecular pathways might worsen its advancement. The subject debate, it capacity repress promote tumor growth. activation can apoptosis, proliferation glucose metabolism, facilitate spread through EMT. Inhibiting hinder enhance respond treatment. regulated several signaling pathways, such STAT3, Wnt, miRNAs, lncRNAs, circRNAs. Utilizing anticancer drugs target may advantageous implications for efficacy cancer

Язык: Английский

Процитировано

6

ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage DOI Creative Commons
Qianqian Su, Lingyan Wu, Chunyan Zheng

и другие.

Environment International, Год журнала: 2024, Номер 190, С. 108897 - 108897

Опубликована: Июль 20, 2024

The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous studies, including our own, shown that can impair learn memory functions as an epigenetic hazard, even at low concentrations. In this study, we explore mechanisms Co-induced ferroptosis neurodegenerative damage both vivo vitro, focusing on regulation by N6-methyladenosine (m

Язык: Английский

Процитировано

3

Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions DOI Open Access
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2969 - 2969

Опубликована: Март 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Язык: Английский

Процитировано

0

Exploration of the role of immune cells and cell therapy in hepatocellular carcinoma DOI Creative Commons
Tao Zhang, Chongyang Ren, Zhanyu Yang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Hepatocellular carcinoma stands as one of the foremost contributors to cancer-associated fatalities globally, and limitations traditional treatment methods have prompted researchers explore new therapeutic options. Recently, cell therapy has emerged a promising approach for HCC, showing significant potential in improving patient outcomes. This review article explores use covering different types, mechanisms behind their effectiveness, recent advancements clinical trials, ongoing challenges. aims provide insightful perspectives future research applications treating HCC by synthesizing current knowledge.

Язык: Английский

Процитировано

0

Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy DOI

Peiyun Liao,

Ying Zhou,

Yingqi Qiu

и другие.

Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(2)

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0

Mitochondrial metabolism: A moving target in hepatocellular carcinoma therapy DOI
Monika Komza, Jerry E. Chipuk

Journal of Cellular Physiology, Год журнала: 2024, Номер 240(1)

Опубликована: Сен. 26, 2024

Abstract Mitochondria are pivotal contributors to cancer mechanisms due their homeostatic and pathological roles in cellular bioenergetics, biosynthesis, metabolism, signaling, survival. During transformation tumor initiation, mitochondrial function is often disrupted by oncogenic mutations, leading a metabolic profile distinct from precursor cells. In this review, we focus on hepatocellular carcinoma, arising metabolically robust nutrient rich hepatocytes, discuss the mechanistic impact of altered metabolism setting. We provide distinctions between normal activity versus disease‐related which yielded therapeutic opportunities, along with highlighting recent preclinical clinical efforts focused targeting metabolism. Finally, several novel strategies for exploiting programs eliminate carcinoma cells metabolism‐specific contexts presented integrate these concepts gain foresight into future mitochondria‐focused therapeutics.

Язык: Английский

Процитировано

2

Advances in Immune Checkpoint Therapy in Hepatocellular Carcinoma DOI

Yamei Huang,

Weiping Yu

British Journal of Hospital Medicine, Год журнала: 2024, Номер unknown, С. 1 - 21

Опубликована: Сен. 30, 2024

The incidence and lethality of hepatocellular carcinoma (HCC) are increasing annually, traditional treatments have been proven to be ineffective for patients with advanced stages the disease. In recent years, immune checkpoint therapy has rapidly evolved, demonstrating promising results across a wide range cancers offering new hope cancer treatment. However, efficacy in HCC varies greatly among individuals, only small proportion responding positively. A major cause resistance poor is evasion, which often due insufficient infiltration cells. Understanding mechanisms underlying evasion crucial enhancing therapies. this review, we aim summarize observed during discuss future directions therapeutic approach. Our goal provide insights that could help overcome thereby improving therapies extending patient survival time.

Язык: Английский

Процитировано

1