
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июль 29, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июль 29, 2024
Язык: Английский
Trends in Cell Biology, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which contexts determine roles of autophagy in ferroptosis. This opinion article addresses this by summarizing and/or diseases a driver or suppressor The execution ferroptosis depends levels (labile) iron, unsaturated (phospho)lipids and free radicals. We propose that context these three factors their upstream pathways are differentially regulated dictates whether positively negatively regulates
Язык: Английский
Процитировано
1Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116790 - 116790
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0Human Cell, Год журнала: 2025, Номер 38(3)
Опубликована: Март 8, 2025
Язык: Английский
Процитировано
0Molecular Medicine, Год журнала: 2025, Номер 31(1)
Опубликована: Март 12, 2025
Abstract Chemoresistance continues to pose a significant challenge in managing colorectal cancer (CRC), resulting unfavorable outcomes for patients. Recent findings indicate that ferroptosis, an innovative type of regulated cell death, might influence chemoresistance. In this research, we explored how WW domain-binding protein 1 (WBP1) affects mitochondrial function, growth, and chemoresistance CRC cells. By employing both genetic pharmacological methods, found WBP1 is essential maintaining respiration depletion impaired leading reduced proliferation increased ferroptosis. Exogenous mitochondria from wild-type cells restored proliferation, suppressed ferroptosis WBP1-deficient cells, indicating function acts downstream WBP1. Importantly, demonstrated targeting or its mediated sensitized chemoresistant 5-fluorouracil oxaliplatin by inducing Furthermore, analyzed transcriptome data patients, which indicated expression correlated with poor patients receiving chemotherapy, thus highlighting the clinical significance our observations. Collectively, results pinpoint as modulator imply may represent viable approach tackling These insights offer deeper understanding molecular pathways underlying guide development new treatment options.
Язык: Английский
Процитировано
0Experimental Cell Research, Год журнала: 2025, Номер unknown, С. 114524 - 114524
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110439 - 110439
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0Archives of Microbiology, Год журнала: 2025, Номер 207(6)
Опубликована: Апрель 22, 2025
Язык: Английский
Процитировано
0Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
0