Ferroptosis suppressor 1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI Creative Commons

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 29, 2024

Abstract Oocyte quality is critical for fertilization and embryo development. Recent studies have shown that ferroptosis may compromise oocyte quality. Ferroptosis suppressor protein 1 (FSP1) a inhibitor with an undefined role in regulation during meiotic maturation. Here, we found FSP1 expressed throughout all stages of maturation localizes to the cytoplasm mouse oocytes. A decline expression was observed ovaries oocytes aged mice. Pharmacological inhibition caused failure germinal vesicle breakdown polar body emission, accompanied by spindle abnormalities chromosome misalignment. Moreover, consistently activated assembly checkpoint, inducing arrest. Mechanistically, increased Fe2+ content, elevated dihydroethidium levels, promoted reactive oxygen species buildup, heightened lipid peroxidation. Additionally, it dysregulated ferroptosis-related genes, suggesting underwent ferroptosis. Furthermore, provoked mitochondrial dysfunction, characterized abnormal localization, reduced ATP membrane potential. In summary, our findings demonstrate participates through its involvement iron homeostasis activity, results ferroptosis-dependent failure.

Язык: Английский

Autophagy-dependent versus autophagy-independent ferroptosis DOI Creative Commons

Ye Zhu,

Motoki Fujimaki,

David C. Rubinsztein

и другие.

Trends in Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Ferroptosis is an iron-dependent cell death pathway that, until recently, has been considered to be dependent on autophagy. However, recent studies have reported conflicting results, raising the question about which contexts determine roles of autophagy in ferroptosis. This opinion article addresses this by summarizing and/or diseases a driver or suppressor The execution ferroptosis depends levels (labile) iron, unsaturated (phospho)lipids and free radicals. We propose that context these three factors their upstream pathways are differentially regulated dictates whether positively negatively regulates

Язык: Английский

Процитировано

1
WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma DOI

Tianfeng Yang,

Suyu Zhang, Kun Nie

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116790 - 116790

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0
STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation DOI
Yan Niu, Chunyu Liu, Lizhou Jia

и другие.

Human Cell, Год журнала: 2025, Номер 38(3)

Опубликована: Март 8, 2025

Язык: Английский

Процитировано

0
WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer DOI Creative Commons
Yang Wang,

Dachuan Qi,

Gaoxiang Ge

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Март 12, 2025

Abstract Chemoresistance continues to pose a significant challenge in managing colorectal cancer (CRC), resulting unfavorable outcomes for patients. Recent findings indicate that ferroptosis, an innovative type of regulated cell death, might influence chemoresistance. In this research, we explored how WW domain-binding protein 1 (WBP1) affects mitochondrial function, growth, and chemoresistance CRC cells. By employing both genetic pharmacological methods, found WBP1 is essential maintaining respiration depletion impaired leading reduced proliferation increased ferroptosis. Exogenous mitochondria from wild-type cells restored proliferation, suppressed ferroptosis WBP1-deficient cells, indicating function acts downstream WBP1. Importantly, demonstrated targeting or its mediated sensitized chemoresistant 5-fluorouracil oxaliplatin by inducing Furthermore, analyzed transcriptome data patients, which indicated expression correlated with poor patients receiving chemotherapy, thus highlighting the clinical significance our observations. Collectively, results pinpoint as modulator imply may represent viable approach tackling These insights offer deeper understanding molecular pathways underlying guide development new treatment options.

Язык: Английский

Процитировано

0
FSP1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

и другие.

Experimental Cell Research, Год журнала: 2025, Номер unknown, С. 114524 - 114524

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Targeting mitochondria-regulated ferroptosis: A new frontier in Parkinson’s Disease therapy DOI Creative Commons
Wenjun Wang,

Elizabeth Rosalind Thomas,

Rui Xiao

и другие.

Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110439 - 110439

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Formononetin exerts synergistic action with artesunate against multi-drug-resistant P. falciparum arresting ring-to-schizont transition by inducing reactive oxygen species DOI
Saurabh Kumar,

Deepak Singh Kapkoti,

Pooja Rani Mina

и другие.

Archives of Microbiology, Год журнала: 2025, Номер 207(6)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Exploring the Therapeutic Targets and Mechanisms of Lanxangia Tsaoko Methanol Extract in Ulcerative Colitis Using Uhplc-Qtof-Ms/Ms and Multi-Omics Analysis DOI

Jun Ge,

Xingke Zhu, Cheng Li

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Ferroptosis suppressor 1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI Creative Commons

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 29, 2024

Abstract Oocyte quality is critical for fertilization and embryo development. Recent studies have shown that ferroptosis may compromise oocyte quality. Ferroptosis suppressor protein 1 (FSP1) a inhibitor with an undefined role in regulation during meiotic maturation. Here, we found FSP1 expressed throughout all stages of maturation localizes to the cytoplasm mouse oocytes. A decline expression was observed ovaries oocytes aged mice. Pharmacological inhibition caused failure germinal vesicle breakdown polar body emission, accompanied by spindle abnormalities chromosome misalignment. Moreover, consistently activated assembly checkpoint, inducing arrest. Mechanistically, increased Fe2+ content, elevated dihydroethidium levels, promoted reactive oxygen species buildup, heightened lipid peroxidation. Additionally, it dysregulated ferroptosis-related genes, suggesting underwent ferroptosis. Furthermore, provoked mitochondrial dysfunction, characterized abnormal localization, reduced ATP membrane potential. In summary, our findings demonstrate participates through its involvement iron homeostasis activity, results ferroptosis-dependent failure.

Язык: Английский

Процитировано

0