medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 11, 2023
SUMMARY
Glucocorticoids
(GCs)
are
used
as
anti-inflammatory
and
immunosuppressive
drugs
in
many
immune
mediated
diseases,
but
their
use
sepsis
shock
is
controversial.
This
caused
part
by
a
lack
of
information
regarding
the
responding
cell
types
GC-regulated
genes
vivo
.
We
public
blood
transcriptomic
datasets
GC-induced
query
to
obtain
2
robust
gene
expression
correlation
signatures
GC
induction,
either
absence
or
presence
severe
inflammation.
signature
1
originated
from
circadian
cortisol
with
biases
for
NK
cells
neutrophils.
inflammation,
mainly
monocytes
Many
upregulated
treatment
septic
burn
were
also
present
high-ranking
signatures,
which
pointed
direct
regulation
GC.
Robust
obtained
dataset
collections
neutrophils,
separately,
predicted
cellular
effects.
Additionally,
induction
was
put
into
wider
framework
circulating
neutrophils
health
systemic
interpret
large
number
different
tissues,
select
whole
biomarker
sets,
GC-1
GC-2,
monitoring
action
health,
respectively.
found
other
inflammatory
both
GC,
endogenous
The Annual Review of Pharmacology and Toxicology,
Год журнала:
2023,
Номер
64(1), С. 89 - 114
Опубликована: Сен. 19, 2023
Today's
challenge
for
precision
medicine
involves
the
integration
of
impact
molecular
clocks
on
drug
pharmacokinetics,
toxicity,
and
efficacy
toward
personalized
chronotherapy.
Meaningful
improvements
tolerability
and/or
medications
through
proper
administration
timing
have
been
confirmed
over
past
decade
immunotherapy
chemotherapy
against
cancer,
as
well
commonly
used
pharmacological
agents
in
cardiovascular,
metabolic,
inflammatory,
neurological
conditions.
Experimental
human
studies
recently
revealed
sexually
dimorphic
circadian
responses.
Dedicated
randomized
clinical
trials
should
now
aim
to
issue
recommendations
daily
medical
practice,
integrating
innovative
technologies
remote
longitudinal
monitoring
metrics,
statistical
prediction
clock
function
from
single-timepoint
biopsies,
multiscale
biorhythmic
mathematical
modelling.
Importantly,
chronofit
patients
with
a
robust
function,
who
would
benefit
most
chronotherapy,
need
be
identified.
Conversely,
nonchronofit
could
emerging
class
chronobiotics
targeting
clock.
Nutrients,
Год журнала:
2023,
Номер
15(3), С. 607 - 607
Опубликована: Янв. 24, 2023
Gut
microbiota
is
the
largest
and
most
complex
microflora
in
human
body,
which
plays
a
crucial
role
health
disease.
Over
past
20
years,
bidirectional
communication
between
gut
extra-intestinal
organs
has
been
extensively
studied.
A
better
comprehension
of
alternative
mechanisms
for
physiological
pathophysiological
processes
could
pave
way
health.
Cardiovascular
disease
(CVD)
one
common
diseases
that
seriously
threatens
Although
previous
studies
have
shown
cardiovascular
diseases,
such
as
heart
failure,
hypertension,
coronary
atherosclerosis,
are
closely
related
to
microbiota,
limited
understanding
pathogenesis
leads
poor
effectiveness
clinical
treatment.
Dysregulation
inflammation
always
accounts
damaged
gastrointestinal
function
deranged
interaction
with
system.
This
review
focuses
on
characteristics
CVD
significance
regulation
during
whole
process.
In
addition,
strategies
prevent
treat
through
proper
its
metabolites
also
discussed.
Frontiers in Immunology,
Год журнала:
2023,
Номер
13
Опубликована: Фев. 14, 2023
Shift
work
is
associated
with
systemic
chronic
inflammation,
impaired
host
and
tumor
defense
dysregulated
immune
responses
to
harmless
antigens
such
as
allergens
or
auto-antigens.
Thus,
shift
workers
are
at
higher
risk
develop
a
autoimmune
disease
circadian
disruption
sleep
impairment
seem
be
the
key
underlying
mechanisms.
Presumably,
disturbances
of
sleep-wake
cycle
also
drive
skin-specific
diseases,
but
epidemiological
experimental
evidence
so
far
scarce.
This
review
summarizes
effects
work,
misalignment,
poor
sleep,
effect
potential
hormonal
mediators
stress
melatonin
on
skin
barrier
functions
innate
adaptive
immunity.
Human
studies
well
animal
models
were
considered.
We
will
address
advantages
pitfalls
in
possible
confounders
that
could
diseases
adverse
lifestyle
habits
psychosocial
influences.
Finally,
we
outline
feasible
countermeasures
may
reduce
autoimmunity
workers,
treatment
options
highlight
outstanding
questions
should
addressed
future
studies.
Abstract
Study
Objectives
Although
poor
sleep
quality
is
associated
with
lower
CD4+
T
cell
counts
among
people
living
HIV
(PLWH),
the
association
between
objective
metrics
and
lymphocyte
subset
unknown.
We
evaluated
polysomnography
(PSG)
derived
subpopulations
in
a
cohort
of
men
HIV.
Methods
Virally
suppressed
participating
Multicenter
AIDS
Cohort
underwent
home
overnight
PSG.
assessed
PSG
parameters
CD8+
CD4+/CD8+
ratio.
Results
Overall,
289
mean
(±SD)
age
55.3
±11.3
years
count
730
±308
cells/mm3
were
evaluated.
Total
time
(TST)
was
significantly
but
not
counts.
After
adjusting
for
age,
race,
depressive
symptoms,
antidepressant
use,
non-nucleoside
reverse
transcriptase
inhibitors
every
hour
shorter
TST
an
additional
33
circulating
(p=0.05)
5.6%
(p=0.0007)
decline
In
adjusted
models,
REM
113
(p=0.02)
15.1%
ratio
(p=0.006).
contrast,
measures
efficiency
sleep-disordered
breathing
differences
subpopulations.
Conclusions
Our
findings
suggest
that
durations
are
Addressing
may
reflect
novel
opportunity
to
improve
immune
function
PLWH.
Asia-Pacific Journal of Pharmacotherapy & Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
The
circadian
clock
and
its
inherent
rhythms
serve
as
the
foundation
for
regulating
many
of
body’s
vital
processes.
Recent
advances
in
medicine
have
leveraged
these
natural
cycles
through
chronotherapy,
practice
timing
drug
administration
to
align
with
body's
internal
clock,
enhance
treatment
outcomes.
Endogenous
clocks
not
only
dictate
physiological
but
also
influence
how
drugs
are
absorbed,
distributed,
metabolized,
excreted,
thereby
affecting
both
their
therapeutic
efficacy
potential
toxicity.
When
disrupted,
resulting
imbalance
has
been
linked
a
range
disorders,
such
cancer
cardiovascular
diseases,
highlighting
growing
need
time-sensitive
strategies.
Technological
breakthroughs,
including
wearable
sensors,
digital
health
platforms,
sophisticated
machine
learning
techniques,
now
allow
continuous,
real-time
monitoring
biomarkers,
which
turn
helps
optimize
regimens.
In
oncology,
example,
synchronizing
chemotherapy,
therapy,
immunotherapy
anti-inflammatory
patient’s
cycle
shown
effectiveness
improve
tolerability.
Moreover,
observed
sex-based
differences
responses
emphasize
importance
tailoring
individual
patient
profiles.
Emerging
research
is
focusing
on
directly
targeting
molecular
components,
showing
treating
metabolic
oncological
conditions.
However,
fully
integrating
chronopharmacology
into
clinical
will
require
development
standardized
protocols,
regulatory
backing,
large-scale
trials
that
incorporate
biomarkers.
Ultimately,
merging
biology
strategies
promises
efficacy,
minimize
side
effects,
Future
studies
must
address
inter-individual
variability,
sex
differences,
misalignment
harness
chronotherapy’s
personalized
medicine.
Frontiers in Network Physiology,
Год журнала:
2025,
Номер
5
Опубликована: Апрель 10, 2025
The
global
rise
of
autoimmune
diseases
presents
a
significant
medical
challenge,
with
inadequate
treatment
options,
high
morbidity
risks,
and
escalating
healthcare
costs.
While
the
underlying
mechanisms
disease
development
are
not
fully
understood,
both
genetic
predispositions
lifestyle
factors,
particularly
sleep,
play
critical
roles.
Insomnia
circadian
rhythm
sleep
disorders
only
impair
but
also
disrupt
multi-organ
interactions
by
dysregulating
sympathetic
nervous
system
activity,
altering
immune
responses,
influencing
neuroendocrine
function.
These
disruptions
can
contribute
to
dysregulation,
increasing
risk
development.
To
assess
impact
impaired
on
developing
diseases,
population-based
retrospective
cohort
study
was
conducted
using
electronic
health
records
from
TriNetX
US
Global
Collaborative
Network,
including
351,366
subjects
in
each
propensity
score
matched
group.
Twenty
were
examined,
matching
employed
reduce
bias.
Three
sensitivity
analyses
test
robustness
results.
identified
significantly
increased
risks
for
several
associated
likely
mediated
dysregulated
neuroimmune
autonomic
interactions.
Specifically,
cutaneous
lupus
erythematosus
[hazard
ratio
(HR)
=
2.119;
confidence
interval
(CI)
1.674-2.682;
p
<
0.0001],
rheumatoid
arthritis
(HR
1.404;
CI
1.313-1.501;
0.0001),
Sjögren
syndrome
1.84;
1.64-2.066;
thyroiditis
1.348;
1.246-1.458;
0.0001)
showed
risks.
No
demonstrated
reduced
4
out
20
tested
did
show
HR
increases
any
analysis.
This
highlights
integral
role
maintaining
homeostasis
through
involving
system,
signalling
pathways,
endocrine
regulation.
Disruptions
these
systems
due
chronic
impairment
may
predispose
individuals
inflammatory
responses
tolerance.
findings
underscore
necessity
recognizing
treating
general
wellbeing
as
potential
strategy
mitigate
long-term
Oxford University Press eBooks,
Год журнала:
2025,
Номер
unknown, С. 137 - 144
Опубликована: Апрель 1, 2025
Abstract
Sleep
is
important
for
immune
health.
There
evidence
that
sleep
deficiency
increases
susceptibility
to
infections
as
well
multiple
chronic
diseases,
in
which
immunopathology
plays
a
role,
such
neurodegenerative
cardiovascular
and
cancer.
affects
both
the
innate
adaptive
arms
of
system,
could
be
central
pathways
mediating
association
between
various
diseases.
In
particular,
has
been
shown
increase
classical
pro-inflammatory
markers,
white
blood
cell
numbers,
certain
cytokines,
C-reactive
protein
(CRP),
while
counter-inflammatory
factors,
cortisol,
become
dysregulated.
At
same
time,
following
vaccination
can
strongly
support
immunity
by
promoting
T
responses
antibody
production.
this
chapter,
we
will
dive
deeper
into
relevance
immune-associated
diseases
give
an
overview
scientific
related
effects
on
different
aspects
function.
