Shared genetic architecture of Genitourinary Cancer and Heart Failure DOI Creative Commons
Hai Jiang,

Ming Cheng Liu,

Cheng Xia

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 6, 2023

Abstract Background Epidemiological and clinical investigations have established a robust correlation between Cancer Heart Failure, with patients afflicted by either condition being at an elevated risk of developing the other.But existence shared genetic etiology remains elusive.The objective was to ascertain genitourinary cancer heart failure. Methods Conducted association analysis common tumors failure using genome-wide study data. Identified corresponding pleiotropic loci genes through various statistical methods, performed tissue immune cell enrichment analyses for these genes. Furthermore, evaluated causal relationship them two-sample Mendelian randomization. Results significant bases among Bladder, Endometrial, Kidney Specifically, discovered 5 loci: rs10757277, rs1537372, rs543968, rs653178 rs56094641. These are associated related such as CDKN2B-AS1,ANRIL, ABO, ATXN2 , FTO . CADM2 CELSR2 were identifiedgene. Pleiotropy found be significantly enriched in tissues including prostate, cervix, testis intestinal-terminalileum et cetera. Additionally, diverse range cells specifically two types diseases. randomization provided suggestive evidence findings. Conclusions Endometrial,Kidney underlying mechanisms genetic. Our results also suggest that system plays important role diseases.These findings provide support basis both disease offer novel targeted therapeutic interventions against them.

Язык: Английский

The Implication of the Gut Microbiome in Heart Failure DOI Creative Commons
Vasile Valeriu Lupu, Anca Adam Răileanu, Cristina Maria Mihai

и другие.

Cells, Год журнала: 2023, Номер 12(8), С. 1158 - 1158

Опубликована: Апрель 14, 2023

Heart failure is a worldwide health problem with important consequences for the overall wellbeing of affected individuals as well healthcare system. Over recent decades, numerous pieces evidence have demonstrated that associated gut microbiota represent an component human physiology and metabolic homeostasis, can affect one’s state or disease directly, through their derived metabolites. The advances in microbiome studies shed light on relationship between cardiovascular system, revealing its contribution to development heart failure-associated dysbiosis. HF has been linked dysbiosis, low bacterial diversity, intestinal overgrowth potentially pathogenic bacteria decrease short chain fatty acids-producing bacteria. An increased permeability allowing microbial translocation passage bacterial-derived metabolites into bloodstream progression. A more insightful understanding interactions microbiome, risk factors mandatory optimizing therapeutic strategies based modulation offering individualized treatment. purpose this review summarize available data regarding influence communities HF, order obtain better multi-layered complex relationship.

Язык: Английский

Процитировано

46
The Role of Gut Microbiota and the Potential Effects of Probiotics in Heart Failure DOI Creative Commons
Carmine Petruzziello, Angela Saviano, Luca Manetti

и другие.

Medicina, Год журнала: 2024, Номер 60(2), С. 271 - 271

Опубликована: Фев. 4, 2024

Heart failure (HF) remains a significant global health challenge, affecting millions of individuals worldwide and posing substantial burden on healthcare systems. HF is syndrome intricate pathophysiology, involving systemic inflammation, oxidative stress, metabolic perturbations, maladaptive structural changes in the heart. It influenced by complex interactions between cardiac function, physiology, environmental factors. Among these factors, gut microbiota has emerged as novel intriguing player landscape pathophysiology. The microbiota, beyond its role digestion nutrient absorption, impacts immune responses, processes, and, suggested evidence literature, development progression HF. There bidirectional communication heart, often known gut–heart axis, through which microbiota-derived metabolites, signals, microbial products exert profound effects cardiovascular health. This review aims to provide comprehensive overview relationship Additionally, we explore potential using probiotics therapeutic strategy modulate microbiota’s composition attenuate adverse observed Conventional approaches targeting hemodynamic neurohormonal dysregulation have substantially improved management HF, but emerging research exploring implications harnessing for innovative treatment.

Язык: Английский

Процитировано

9
Epigenetics of Early Cardiometabolic Disease: Mechanisms and Precision Medicine DOI Open Access
Andrea Baccarelli, José M. Ordovás

Circulation Research, Год журнала: 2023, Номер 132(12), С. 1648 - 1662

Опубликована: Июнь 8, 2023

Epigenetics has transformed our understanding of the molecular basis complex diseases, including cardiovascular and metabolic disorders. This review offers a comprehensive overview current state knowledge on epigenetic processes implicated in highlighting potential DNA methylation as precision medicine biomarker examining impact social determinants health, gut bacterial epigenomics, noncoding RNA, epitranscriptomics disease development progression. We discuss challenges barriers to advancing cardiometabolic epigenetics research, along with opportunities for novel preventive strategies, targeted therapies, personalized approaches that may arise from better processes. Emerging technologies, such single-cell sequencing editing, hold further enhance ability dissect interplay between genetic, environmental, lifestyle factors. To translate research findings into clinical practice, interdisciplinary collaborations, technical ethical considerations, accessibility resources are crucial. Ultimately, field revolutionize way we approach paving health care, improving lives millions individuals worldwide affected by these conditions.

Язык: Английский

Процитировано

20
Systematic Review of Probiotics and Their Potential for Developing Functional Nondairy Foods DOI Creative Commons
Ricardo S. Alemán,

Ajitesh Yadav

Applied Microbiology, Год журнала: 2023, Номер 4(1), С. 47 - 69

Опубликована: Дек. 26, 2023

The gastrointestinal tract is an environment that hosts various microorganisms, including pathogens. Generally, pathogenic bacteria enter the host body through food and tract. These can colonize or infiltrate cells tissues, causing infectious diseases. In recent years, protective role of probiotic against pathogens has been carefully investigated. Probiotics have found to modulate intestinal microbial flora play a significant in tract’s function, especially by inhibiting growth bacteria. However, mechanism action probiotics yet be sufficiently proven recognized. Several important mechanisms support antagonistic effects on which achieved, for example, production different antimicrobial compounds, such as bacteriocins, organic acids, antibiotics, proteins, exopolysaccharides; mucosal barriers with mucosa binding blockers; competition nutrient uptake; strengthening immune system. Accordingly, this review summarizes studies examined their beneficial preventing bacterial improving functions. Comprehending allows selection appropriate strains specific applications dysfunction.

Язык: Английский

Процитировано

15
Gut Permeability and Immune-Mediated Inflammation in Heart Failure DOI Creative Commons

Maria Perticone,

Simona Gigliotti,

Ermal Shehaj

и другие.

Biomedicines, Год журнала: 2024, Номер 12(6), С. 1217 - 1217

Опубликована: Май 30, 2024

Heart failure (HF) is characterized by low-grade immune-mediated inflammation due to increased Toll-like receptor (TLR) expression as response endotoxin increase and dysregulated gut barrier permeability. We investigated TLR possible dysbiosis in HF patients compared a control group. enrolled 80 Caucasian 20 controls. Low-grade was evaluated expression, while the detection of zonulin bacterial activity semi-quantitative (endotoxin assay [EAA]) quantitative (limulus amebocyte lysate [LAL] test) way. Compared controls, with showed significantly higher age blood pressure values, worse metabolic profile kidney function, inflammatory biomarkers levels, lower levels activity. When dividing failing those reduced ejection fraction (HF-rEF) preserved (HF-pEF), HF-rEF values than HF-pEF patients. Gut permeability inversely correlated severity positively renal function. eGFR retained an independent predictor variation all three groups Present data work extend current knowledge about role microbiota HF.

Язык: Английский

Процитировано

4
Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease DOI Creative Commons

Debin Chen,

Yongju Ye,

Yining Li

и другие.

Renal Failure, Год журнала: 2025, Номер 47(1)

Опубликована: Янв. 6, 2025

Background Chronic kidney disease (CKD) is a prevalent chronic, non-communicable disease. The long-term health effects of dietary live microbes, primarily probiotics, on CKD patients remain insufficiently understood. This study aims to investigate the association between intake microbes and outcomes among individuals with CKD.

Язык: Английский

Процитировано

0
Cardiovascular protective effects of natural flavonoids on intestinal barrier injury DOI
Peng Zhou, Hui-juan Xu, Liang Wang

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Язык: Английский

Процитировано

0
Potential therapeutic solution for Clostridioides difficile infection: current scenario and future prospects DOI Creative Commons

Chandrashekhar Singh,

Anjali Singh,

Deepjyoti Singh

и другие.

Medicine in Microecology, Год журнала: 2025, Номер unknown, С. 100121 - 100121

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Deciphering the tripartite interaction of urbanized environment, gut microbiome and cardio-metabolic disease DOI

Avaneesh Shukla,

Chanchal Sharma, Md. Zubbair Malik

и другие.

Journal of Environmental Management, Год журнала: 2025, Номер 377, С. 124693 - 124693

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

0
Benefits of Biotics for Cardiovascular Diseases DOI Open Access
Emília Hijová

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6292 - 6292

Опубликована: Март 27, 2023

Cardiovascular diseases are the main cause of death in many countries, and better prevention prediction these would be great importance for individuals society. Nutrition, gut microbiota, metabolism have raised much interest field cardiovascular disease research search mechanisms that promote diseases. Understanding interactions between dietary nutrient intake microbiota-mediated may provide clinical insight order to identify at risk cardiometabolic progression, as well other potential therapeutic targets mitigate progression. The development can modulated by specific beneficial metabolites derived from bacteria. Therefore, it is very important investigate impact on human health possibilities modulating their production with supplements called biotics.

Язык: Английский

Процитировано

10