Journal of Medicine Surgery and Public Health, Год журнала: 2024, Номер 3, С. 100134 - 100134
Опубликована: Авг. 1, 2024
Язык: Английский
Molecules, Год журнала: 2025, Номер 30(7), С. 1419 - 1419
Опубликована: Март 22, 2025
Introduction: Currently, there are no effective medications for treating all the clinical conditions of patients with COVID-19. We aimed to evaluate antiviral activity compounds derived from L-tyrosine against B.1 lineage SARS-CoV-2 in vitro and silico. Methodology: The cytotoxicities 15 halogenated were evaluated Vero-E6 cells by MTT assay. was using four strategies, viral quantification performed a plaque assay qRT-PCR. toxicity ADMET predictor software. affinity these or cellular proteins stability their conformations determined docking molecular dynamics, respectively. Results: TODC-3M, TODI-2M, YODC-3M reduced titer >40% inhibited replication RNA without significant cytotoxicity. In silico analyses revealed that presented low binding energies between −4.3 −5.2 Kcal/mol three (spike, Mpro, RdRp). TODC-3M most stable proteins. Conclusions: promising YODC-3M, which toxicity, potential through different favorable affinities targets. Therefore, they candidates vivo studies.
Язык: Английский
Процитировано
1
Vaccines, Год журнала: 2024, Номер 12(8), С. 885 - 885
Опубликована: Авг. 4, 2024
The COVID-19 pandemic, with over 775 million cases and 7 deaths by May 2024, has drastically impacted global public health exacerbated existing healthcare inequalities. swift development distribution of vaccines have been critical in combating the virus, yet disparities access to administration vaccine highlighted deep-seated inequities at global, regional, national levels. Wealthier nations benefited from early vaccines, while low- middle-income countries (LMICs) faced persistent shortages. Initiatives such as COVAX aimed address these disparities, but challenges persist. Socioeconomic factors, education, ethnic identity, infrastructure play crucial roles equity. For example, lower-income individuals often face barriers poor healthcare, misinformation, logistical challenges, particularly rural areas. Addressing requires a multifaceted approach, integrating policies local strategies enhance vaccines' accessibility, counter ensure equitable distribution. Collaborative efforts all levels are essential promote equity effectively control ensuring that populations fair life-saving vaccines. This review explores complex issues, offering insights into facilitators providing recommendations more effective vaccination programs. With focus on different which planned implemented, text provides guidelines steer strategies, emphasizing role international cooperation policy frameworks keys achieving coverage.
Язык: Английский
Процитировано
5
Infectious Diseases and Therapy, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Vaccination represents a core preventive strategy for public health, with interrelated and multifaceted effects across health socioeconomic domains. Beyond immediate disease prevention, immunization positively influences downstream outcomes by mitigating complications of preexisting comorbidities promoting healthy aging. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza virus, syncytial virus (RSV) are common viruses responsible broad societal cost substantial morbidity mortality, particularly among at-risk individuals, including older adults people frailty or certain comorbid conditions. In this narrative review, we summarize the overall impact vaccination these 3 viruses, focusing on mRNA vaccines, each which exhibits unique patterns infection, risk, transmission dynamics, but collectively represent target strategies. Vaccines COVID-19 (caused SARS-CoV-2) effective against most severe outcomes, such as hospitalization death; vaccines potent cost-effective interventions protection population individual influenza, those Based promising results efficacy prevention RSV-associated lower tract disease, first RSV were approved in 2023. Immunization strategies should account various factors leading to poor uptake, vaccine hesitancy, barriers access, cultural beliefs, lack knowledge states. Coadministration combination multicomponent offer potential advantages logistics delivery, thus improving uptake reducing adoption new vaccines. The success platform was powerfully demonstrated during pandemic; other approaches show promise means overcome existing challenges development sustain viral changes over time.A graphical abstract video is available article.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 8, 2025
The outbreak of novel infectious diseases presents major public health challenges, highlighting the urgency accelerating vaccination efforts to reduce morbidity and mortality. Vaccine allocation has become a crucial societal concern. This paper introduces dynamic vaccine model that considers demand uncertainty willingness, focusing on trade-off between fairness efficiency. We develop multi-period model, evaluating optimal strategies over different periods. addresses structural differences among groups, strategy selection, demand, willingness. Our findings suggest prioritizing efficiency in initial stages may lead inequitable distribution, causing adverse social impacts, while overemphasizing can undermine overall utility. Therefore, we propose optimization-based balancing at pandemic stages. results indicate should shift from as evolves enhance Additionally, macro-level interventions like reducing free-rider behavior increasing convenience improve total study offers new perspectives methodologies for allocation, efficiency, providing insights policy formulation response.
Язык: Английский
Процитировано
0
BMJ Global Health, Год журнала: 2025, Номер 10(1), С. e015693 - e015693
Опубликована: Янв. 1, 2025
Gross domestic product (GDP) has been shown to affect government spending on various budget heads including healthcare and the purchase distribution of vaccines. This vulnerable situation exacerbated by COVID-19 pandemic which disrupted exposed fragile nature equitable access vaccines for childhood immunisation globally. A systematic review meta-analysis assess association country income status GDP with vaccination coverage other major infectious diseases around globe will inform global national policy equity in living standards vaccine uptake. study was carried out identify factors influenced that access, distribution, uptake world using a approach. Data were extracted burden programmes, affecting vaccines, procurement platforms, percentage used Factors influencing rate also assessed. The protocol registered PROSPERO (ID: CRD42022350418) Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines. from 195 countries showed following had highest burden; human papillomavirus (HPV), measles, Ebola yellow fever. Low-income some lower-middle-income (LMICs) COVAX UNICEF while high-income (HICs) preferred regional public tenders. Global tuberculosis, diphtheria/tetanus/pertussis, hepatitis B, Haemophilus influenzae type b, polio, meningitis HPV significantly higher than COVID-19. Being an HIC having data collected 1985 2015 as most current associated high coverage. spent did not influence LMICs should prioritise research improve development capacity. Countries worldwide share expenditure, coverage, introduction new technologies facilitate access.
Язык: Английский
Процитировано
0
BMC Health Services Research, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15
Опубликована: Фев. 17, 2025
Background Most children in Argentina received only the initial COVID-19 vaccine series, with presumed hybrid immunity after multiple Omicron waves. However, durability of immune memory, particularly immunocompromised (IC) children, remains poorly studied. Methods A cohort IC (n=45) and healthy (HC, n=79) was assessed between 13 to 17 months receiving two or three doses BBIBP-CorV and/or BNT162b2. Plasma anti-spike IgG, neutralizing activity antigen-specific CD4+ CD8+ T cells against Wuhan BA.5 variants were assessed. Results remained seropositive doses, but compared HC, exhibited lower titers both BA.5, those vaccinated BBIBP-CorV. Even showed weaker antibody response, cell responses IFN-γ production HC. Integrated analysis antibodies, memory CD4 + , CD8 revealed a weak among an important compromise responses. Conclusions Immunity can last up months, reduced effectiveness new highlights need for updated vaccines, especially children. Additional efforts are essential enhance vaccination coverage protect this vulnerable population.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106813 - 106813
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Public Health, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Abstract Background The World Health Organization’s convention, agreement or other international instrument on pandemic prevention, preparedness, and response, often referred to as the ‘pandemic treaty’, was established with principles guide implementation. treaty’s underlying ethic cosmopolitan in intent, emphasizing equal value of all people obligations stemming from shared humanity. Methods working draft 13 July 2022 proposed 22 April 2024 were compared by textual analysis for content sequence. Changes analysed using ethical framework cosmopolitanism associated public health implications identified. Results Compared draft, consolidated such solidarity reduced specific obligations, weakening demands. Sovereignty elevated cardinal principle, while tied equity human rights less specific, reflecting a shift intentions emphasis cooperation goals. Conclusions made through treaty negotiation process suggest amnesia, undermining global equity, justice, consequences preparedness. Strengthening text is essential embed collective motivation necessary effective before next pandemic.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106940 - 106940
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0