Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Год журнала: 2025, Номер 15(2), С. 270 - 270

Опубликована: Фев. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Язык: Английский

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Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 289, С. 138633 - 138633

Опубликована: Дек. 13, 2024

Язык: Английский

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In vitro gastrointestinal digestion and colonic fermentation of Mangiferin: Impacts on gut microbiota and metabolite profiles

Journal of Functional Foods, Год журнала: 2025, Номер 124, С. 106667 - 106667

Опубликована: Янв. 1, 2025

Язык: Английский

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Protective role of short-chain fatty acids on intestinal oxidative stress induced by TNF-α

Cell Stress and Chaperones, Год журнала: 2024, Номер 29(6), С. 769 - 776

Опубликована: Ноя. 14, 2024

Inflammatory bowel diseases (IBDs) are driven by an exaggerated inflammatory response, which leads to a marked increase in oxidative stress. This, turn, exacerbates the process and causes significant cellular tissue damage. Intestinal dysbiosis, common observation IBD patients, alters production of bacterial metabolites, including short-chain fatty acids (SCFAs), key by-products dietary fiber fermentation. While role SCFAs intestinal physiology is still being elucidated, this study aimed investigate their effects on stress, particularly under conditions induced proinflammatory mediator tumor necrosis factor alpha (TNF-α). The Caco-2/TC7 cell line was employed as vitro model epithelium, cells were treated with range SCFAs, acetate, propionate, butyrate. levels protein lipid oxidation quantified, well activity antioxidant enzymes. Our findings demonstrate that microbiota-derived can effectively mitigate TNF-α-induced stress modulating enzyme activity. TNF-α induces peroxidation inhibiting catalase glutathione peroxidase activities. able upregulate restore levels. These results underscore critical gut microbiota maintaining homeostasis highlight therapeutic potential managing stress-related pathologies.

Язык: Английский

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Peonidin-3-O-(3,6-O-dimalonyl-β-D-glucoside), a polyacylated anthocyanin isolated from the black corncobs, alleviates colitis by modulating gut microbiota in DSS-induced mice

Food Research International, Год журнала: 2025, Номер 202, С. 115688 - 115688

Опубликована: Янв. 7, 2025

Язык: Английский

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Gut microbiota and atrial cardiomyopathy

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 4, 2025

Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria closely associated with atrial fibrillation its complications. Its etiology involves number factors, including genetic, infectious, immunologic, metabolic factors. Recent research has highlighted critical role gut microbiota in pathogenesis cardiomyopathy, this consistent gut–heart axis having major implications for cardiac health. The aim work to bridge knowledge gap regarding interactions between particular focus on elucidating mechanisms which dysbiosis may induce remodeling dysfunction. This article provides an overview changes composition effects metabolites. We also discuss how diet exercise affect influencing microbiota, as well possible future therapeutic approaches targeting axis. A healthy can prevent disease, but ecological lead variety symptoms, induction disease. pathophysiological aspects impact structure function, strategies exploring modulation treatment cardiomyopathy. Finally, we fecal transplantation oral probiotics or prebiotics. Our study highlights importance homeostasis cardiovascular health suggests that targeted interventions pave way innovative preventive

Язык: Английский

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Nanotechnology-driven EGCG: bridging antioxidant and therapeutic roles in metabolic and cancer pathways

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Фев. 9, 2025

Epigallocatechin-3-gallate (EGCG), the primary polyphenol in green tea, is renowned for its potent antioxidant properties. EGCG interacts with various cellular targets, inhibiting cancer cell proliferation through apoptosis and cycle arrest induction, while also modulating metabolic pathways. Studies have demonstrated potential addressing development, obesity, diabetes. Given rising prevalence of diseases cancers, increasingly recognized as a promising therapeutic agent. This review provides comprehensive overview latest findings on effects both free nano-encapsulated mechanisms involved management prevention hyperlipidemia, diabetes, gastrointestinal (GI) cancers. The highlights role key signaling pathways, enhancing bioavailability nano-formulations, applications clinical settings.

Язык: Английский

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Alleviating effect of Lactobacillus fermentum E15 on hyperlipidemia and hepatic lipid metabolism in zebrafish fed by a high-fat diet through the production of short-chain fatty acids

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 3, 2025

Introduction Hyperlipidemia is regarded as one of the crucial factors leading to atherosclerosis and other cardiovascular diseases. Gut microbiota plays an important role in regulating host lipid metabolism. Nevertheless, exact mechanisms behind this remain unclear. Methods In present study, a hyperlipidemic zebrafish model was established using high-cholesterol diet (HCD) evaluate anti-hyperlipidemic effects Lactobacillus fermentum E15 ( L. E15). Results showed that effectively reduced accumulation blood vessels liver HCD-fed larvae. Meanwhile, improved abnormal levels, normalized enzyme activity. Real-time quantitative polymerase chain reaction (RT-qPCR) analysis revealed downregulated expression sterol regulatory element-binding factor (SREBP-1), peroxisome proliferator-activated receptor-gamma (PPAR- γ ), fatty acid synthase (Fasn), while upregulated receptor-alpha α ). Additionally, metabolomic produced series short-chain acids (SCFAs), including acetic acid, propionic butyric isovaleric acid. Notably, contributed reduction droplet contrast, blocking G-protein coupled receptor 43 (GPR43) with pertussis toxin (PTX) abolished on reducing RT-qPCR results further suggested both promoted GPR43 leptin A, which inhibited by PTX. Conclusion These findings alleviates HCD-induced hyperlipidemia activating through SCFAs.

Язык: Английский

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Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 13, 2025

As a critical juncture in the pathological continuum from gastritis to gastric cancer, precancerous lesions of cancer (PLGC) are increasingly prevalent, significantly undermining health global population. The primary constituents bile, specifically bile acids (BAs), disrupt equilibrium hormone secretion and compromise structural integrity mucosa, thereby facilitating oncogenesis. Moreover, gut microbiota modulate host physiological processes through immune response regulation, metabolic pathway interference, direct interaction with tumor cells. Extensive research has elucidated that dysregulation BAs microbiota, concert resultant impairment central pathogenesis PLGC. In anticipation future clinical preventive therapeutic strategies, this review collates recent insights into roles bacteria PLGC, examining their interplay significance pathogenic mechanism

Язык: Английский

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Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma

Cells, Год журнала: 2025, Номер 14(6), С. 466 - 466

Опубликована: Март 20, 2025

Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The microbiome interacts with the via a bidirectional relationship gut–liver axis. Microbial metabolites, sirtuins, responses pivotal in different metabolic diseases. This extensive review explores complex multifaceted interrelationship between sirtuins microbiota, highlighting their importance health disease, particularly hepatocellular carcinoma (HCC). Sirtuins (SIRTs), classified as group of NAD+-dependent deacetylases, serve crucial modulators wide spectrum cellular functions, including pathways, inflammatory response, process senescence. Their subcellular localization diverse functions link them various conditions, NAFLD cancer. Concurrently, comprising microorganisms, significantly influences host metabolism responses. Recent findings indicate modulate microbiota composition function, while can affect sirtuin activity. is relevant disorders, where dysbiosis contributes progression. highlights recent on roles specific maintaining implications HCC development. Understanding these interactions offers potential therapeutic avenues for managing diseases linked dysregulation pathology.

Язык: Английский

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