Transcription regulation by the Mediator complex

Nature Reviews Molecular Cell Biology, Год журнала: 2017, Номер 19(4), С. 262 - 274

Опубликована: Дек. 6, 2017

Язык: Английский

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Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

World Psychiatry, Год журнала: 2018, Номер 17(3), С. 243 - 257

Опубликована: Сен. 7, 2018

This paper reviews the research evidence concerning intergenerational transmission of trauma effects and possible role epigenetic mechanisms in this transmission. Two broad categories epigenetically mediated are highlighted. The first involves developmentally programmed effects. These can result from influence offspring's early environmental exposures, including postnatal maternal care as well utero exposure reflecting stress during pregnancy. second includes changes associated with a preconception parents that may affect germline, impact fetoplacental interactions. Several factors, such sex-specific following parental developmental stage at time exposure, explain different paternal trauma. most compelling work to date has been done animal models, where opportunity for controlled designs enables clear interpretations transmissible Given paucity human studies methodological challenges conducting studies, it is not attribute humans single set biological or other determinants time. Elucidating through prospective, multi-generational ultimately yield cogent understanding how individual, cultural societal experiences permeate our biology.

Язык: Английский

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Physiological and Transcriptome Analyses Reveal Short-Term Responses and Formation of Memory Under Drought Stress in Rice

Frontiers in Genetics, Год журнала: 2019, Номер 10

Опубликована: Фев. 7, 2019

In some plants, exposure to stress can induce a memory response, which appears play an important role in adaptation recurrent environments. However, whether rice exhibits drought and the molecular mechanisms that might underlie this process have remained unclear. Here, we ensured was established after cycles of mild re-watering treatment, studied gene expression by whole-transcriptome strand-specific RNA sequencing (ssRNA-seq). We detected 6,885 transcripts 238 lncRNAs involved grouped into 16 distinct patterns. Notably, identified genes dosage generally did not respond initial treatment. Our results demonstrate be developed under appropriate water deficient stress, lncRNA, DNA methylation endogenous phytohormones (especially abscisic acid) participate short-term memory, possibly acting as factors activate drought-related pathways such photosynthesis proline biosynthesis, subsequent stresses.

Язык: Английский

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Histone H3 lysine K4 methylation and its role in learning and memory

Epigenetics & Chromatin, Год журнала: 2019, Номер 12(1)

Опубликована: Янв. 7, 2019

Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying the underlying genomic sequence. A number of studies animal models have shown that dysregulation various components epigenetic machinery causes cognitive deficits at behavioral level, suggesting proper control is necessary for fundamental processes learning and memory. Histone H3 lysine K4 (H3K4) comprises one component control, global levels this mark are increased hippocampus during memory formation. Modifiers H3K4 needed formation, through studies, many same modifiers mutated human diseases. Indeed, all known methyltransferases four six demethylases been associated with impaired cognition a neurologic or psychiatric disorder. Cognitive impairment patients often manifests intellectual disability, consistent role As modification quintessentially, but not exclusively, transcriptional activity, provides unique insights into regulatory complexity writing, reading, erasing marks within an activated neuron. The following review will discuss connect it to events required developed nervous system. This include initial discussion most recent advances developing methodology analyze methylation, namely mass spectrometry deep sequencing, well how these methods can be applied more deeply understand biology brain. We then introduce core enzymatic mediating addition removal resulting signatures throughout neuronal genome. next foray brain, discussing changes formation retrieval, correlates methyltransferase deficiency region. Finally, we diseases connected each modulator summarize drugs target them.

Язык: Английский

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Chromatin‐based mechanisms of temperature memory in plants

Plant Cell & Environment, Год журнала: 2018, Номер 42(3), С. 762 - 770

Опубликована: Июнь 19, 2018

Abstract For successful growth and development, plants constantly have to gauge their environment. Plants are capable monitor current environmental conditions, they also able integrate conditions over time store the information induced by cues. In a developmental context, such an memory is used align transitions with favourable conditions. One temperature‐related example of this transition flowering after experiencing winter that is, vernalization. context adaptation stress, improve stress even when cues intermittent. A somatic has now been described for various stresses, including extreme temperatures, drought, pathogen infection. At molecular level, environment often mediated epigenetic chromatin modifications. Histone modifications in particular play important role. review, we will discuss compare different types temperature histone modifications, as well reader, writer, eraser proteins involved.

Язык: Английский

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Epigenomics

Circulation Research, Год журнала: 2018, Номер 122(9), С. 1191 - 1199

Опубликована: Апрель 26, 2018

The advent of high-throughput epigenome mapping technologies has ushered in a new era multiomics where powerful tools can now delineate and record different layers genomic output. Integrating various components the from these measurements allows interrogation cellular heterogeneity addition to discovery molecular connectivity maps between genome its functional Mapping chromatin accessibility dynamics higher-order structure enabled levels understanding cell fate decisions, identity, function normal development, physiology, disease. We provide perspective on progress epigenomics field applications anticipate an even greater revolution our human for years come.

Язык: Английский

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Root endophyte induced plant thermotolerance by constitutive chromatin modification at heat stress memory gene loci

EMBO Reports, Год журнала: 2021, Номер 22(3)

Опубликована: Янв. 10, 2021

Abstract Global warming has become a critical challenge to food security, causing severe yield losses of major crops worldwide. Conventional and transgenic breeding strategies enhance plant thermotolerance are laborious expensive. Therefore, the use beneficial microbes could be an alternative approach. Here, we report that root endophyte Enterobacter sp. SA187 induces in wheat laboratory as well open‐field agriculture. To unravel molecular mechanisms, used Arabidopsis thaliana model plant. reprogramed transcriptome via HSFA2 ‐dependent enhancement H3K4me3 levels at heat stress memory gene loci. Unlike thermopriming, SA187‐induced is mediated by ethylene signaling transcription factor EIN3 . In contrast transient chromatin modification constitutive genes, generating robust plants. Importantly, microbial community composition plants agriculture not influenced SA187, indicating can powerful tool sustainable manner.

Язык: Английский

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Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression

Molecular Cell, Год журнала: 2019, Номер 77(1), С. 67 - 81.e7

Опубликована: Ноя. 26, 2019

Язык: Английский

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Stress Memory in Seagrasses: First Insight Into the Effects of Thermal Priming and the Role of Epigenetic Modifications

Frontiers in Plant Science, Год журнала: 2020, Номер 11

Опубликована: Апрель 28, 2020

While thermal priming and the relative role of epigenetic modifications have been widely studied in terrestrial plants, their roles remain unexplored seagrasses so far. Here, we experimentally compared ability two different functional types seagrass species, dominant Southern hemisphere, climax species Posidonia australis pioneer Zostera muelleri, to acquire thermal-stress memory better survive successive stressful events. To this end, a two-heatwave experimental design was conducted mesocosm setup. Findings across levels biological organization including molecular (gene expression), physiological (photosynthetic performances pigments content) organismal (growth) provided first evidence seagrasses. Non-preheated plants suffered significant reduction photosynthetic capacity, leaf growth chlorophyll content, while preheated were able cope with recurrent event. Gene expression results demonstrated regulation methylation-related genes response stress, suggesting that could play central stress memory. In addition, revealed some interspecific differences responses between species. These provide insights into paving way for more comprehensive forecasting management these marine foundation an era rapid environmental change.

Язык: Английский

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Functional mechanisms and abnormalities of the nuclear lamina

Nature Cell Biology, Год журнала: 2021, Номер 23(2), С. 116 - 126

Опубликована: Фев. 1, 2021

Язык: Английский

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