The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response DOI Creative Commons

Tania Veuthey,

Jeremy Florman, Sebastián Giunti

и другие.

PLoS Biology, Год журнала: 2025, Номер 23(1), С. e3002997 - e3002997

Опубликована: Янв. 28, 2025

The DAF-2/insulin/insulin-like growth factor signaling (IIS) pathway plays an evolutionarily conserved role in regulating reproductive development, life span, and stress resistance. In Caenorhabditis elegans , DAF-2/IIS is modulated by extensive array of insulin-like peptides (ILPs) with diverse spatial temporal expression patterns. However, the release dynamics specific functions these ILPs adapting to different environmental conditions remain poorly understood. Here, we show that ILP, insulin-3 (INS-3), a crucial modulating response various stressors C. . ins-3 mutants display increased resistance heat, oxidative stress, starvation; however, this advantage countered slower development under favorable conditions. We find downregulated stressors, whereas, neurohormone tyramine, which released during acute flight response, increases expression. tyramine induces intestinal calcium (Ca 2+ ) transients through activation TYRA-3 receptor. Our data support model negatively impacts stimulating INS-3 from intestine via TYRA-3-G α q -IP3 pathway. systemically activates DAF-2 pathway, resulting inhibition cytoprotective mechanisms mediated DAF-16/FOXO. These studies offer mechanistic insights into brain–gut communication weighs adaptive strategies respond long-term stressors.

Язык: Английский

Carbon catabolite repression: not only for glucose DOI

Kobi J. Simpson-Lavy,

Martin Kupiec

Current Genetics, Год журнала: 2019, Номер 65(6), С. 1321 - 1323

Опубликована: Май 22, 2019

Язык: Английский

Процитировано

26
The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses DOI Creative Commons
Marco Caligaris, Belém Sampaio‐Marques, Riko Hatakeyama

и другие.

Journal of Fungi, Год журнала: 2023, Номер 9(8), С. 787 - 787

Опубликована: Июль 26, 2023

Yeast cells are equipped with different nutrient signaling pathways that enable them to sense the availability of various nutrients and adjust metabolism growth accordingly. These part an intricate network since most cross-regulated subject feedback regulation at levels. In yeast, a central role is played by Sch9, protein kinase functions as proximal effector conserved growth-regulatory TORC1 complex mediate information on free amino acids. However, recent studies established Sch9 more than TORC1-effector its activity tuned several other kinases. This allows function integrator aligns input signals achieve accuracy in metabolic responses stress-related molecular adaptations. this review, we highlight latest findings structure well nutrient-responsive hub impacts longevity yeast cells. Given key players impinging well-conserved, also discuss how can be instrumental further elucidate mechanisms underpinning healthy aging mammalians.

Язык: Английский

Процитировано

9
Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control DOI Creative Commons

Leah E. Escalante,

James Hose,

Hollis Howe

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 23, 2024

Premature aging is a hallmark of Down syndrome, caused by trisomy human chromosome 21, but the reason unclear and difficult to study in humans. We used an aneuploid model wild yeast show that amplification disrupts nutrient-induced cell-cycle arrest, quiescence entry, healthy aging, across genetic backgrounds amplified chromosomes. discovered these defects are due part aneuploidy-induced dysfunction Ribosome Quality Control (RQC). Compared euploids, aneuploids entering display aberrant ribosome profiles, accumulate RQC intermediates, harbor increased load protein aggregates. Although they have normal proteasome capacity, signs ubiquitin dysregulation, which impacts cyclin abundance disrupt arrest. Remarkably, inducing stalling euploids produces similar aberrations, while up-regulating limiting subunits or proteins metabolism alleviates many defects. Our results provide implications for other aneuploidy disorders including syndrome.

Язык: Английский

Процитировано

3
Glucosinolates from Seed-Press Cake of Camelina sativa (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration DOI Creative Commons
Francesco Abbiati, Ivan Orlandi, Stefania Pagliari

и другие.

Antioxidants, Год журнала: 2025, Номер 14(1), С. 80 - 80

Опубликована: Янв. 11, 2025

Glucosinolates (GSLs) are nitrogen/sulfur-containing glycosides widely present in the order of Brassicales, particularly Brassicaceae family. Camelina (Camelina sativa (L.) Crantz) is an oilseed plant belonging to this Its seeds, addition a distinctive fatty acid composition, contain three aliphatic GSLs: glucoarabin, glucocamelinin, and homoglucocamelinin. Our study explored impact these GSLs purified from press cake, by-product oil production, on yeast chronological aging, which established model for simulating aging post-mitotic quiescent mammalian cells. Supplementing cells with extends lifespan (CLS) dose-dependent manner. This enhancement relies improved mitochondrial respiration efficiency, resulting drastic decrease superoxide anion levels increase ATP production. Furthermore, GSL supplementation affects carbon metabolism. In particular, support pro-longevity preservation TCA cycle enzymatic activities enhanced glycerol catabolism. These changes contribute positively phosphorylating trehalose storage: both longevity-promoting prerequisites.

Язык: Английский

Процитировано

0
The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response DOI Creative Commons

Tania Veuthey,

Jeremy Florman, Sebastián Giunti

и другие.

PLoS Biology, Год журнала: 2025, Номер 23(1), С. e3002997 - e3002997

Опубликована: Янв. 28, 2025

The DAF-2/insulin/insulin-like growth factor signaling (IIS) pathway plays an evolutionarily conserved role in regulating reproductive development, life span, and stress resistance. In Caenorhabditis elegans , DAF-2/IIS is modulated by extensive array of insulin-like peptides (ILPs) with diverse spatial temporal expression patterns. However, the release dynamics specific functions these ILPs adapting to different environmental conditions remain poorly understood. Here, we show that ILP, insulin-3 (INS-3), a crucial modulating response various stressors C. . ins-3 mutants display increased resistance heat, oxidative stress, starvation; however, this advantage countered slower development under favorable conditions. We find downregulated stressors, whereas, neurohormone tyramine, which released during acute flight response, increases expression. tyramine induces intestinal calcium (Ca 2+ ) transients through activation TYRA-3 receptor. Our data support model negatively impacts stimulating INS-3 from intestine via TYRA-3-G α q -IP3 pathway. systemically activates DAF-2 pathway, resulting inhibition cytoprotective mechanisms mediated DAF-16/FOXO. These studies offer mechanistic insights into brain–gut communication weighs adaptive strategies respond long-term stressors.

Язык: Английский

Процитировано

0