Protein acetylation regulates xylose metabolism during adaptation of Saccharomyces cerevisiae DOI Creative Commons

Yong-Shui Tan,

Li Wang, Yingying Wang

и другие.

Biotechnology for Biofuels, Год журнала: 2021, Номер 14(1)

Опубликована: Дек. 17, 2021

As the second most abundant polysaccharide in nature, hemicellulose can be degraded to xylose as feedstock for bioconversion fuels and chemicals. To enhance conversion, engineered Saccharomyces cerevisiae with metabolic pathway is usually adapted carbon source laboratory. However, mechanism under adaptation phenomena of strain still unclear.In this study, xylose-utilizing S. was constructed used study. It found that consumption rate increased 1.24-fold incubation yYST12 synthetic complete-xylose medium compared first incubation. The study figured out it observed at single-cell level stagnation time utilization reduced after microfluidic device. Such transient memory metabolism medium, named "xylose memory", strains both isomerase reductase xylitol dehydrogenase pathways. In further, proteomic acetylation before investigated, revealed H4K5 one differential sites related cerevisiae. We tested 8 genes encoding acetylase or deacetylase, knockout GCN5 HPA2 acetylases enhanced memory.The behavior successfully induced adaptation. H4K5Ac two are during This provides valuable insights into

Язык: Английский

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds DOI Creative Commons
Michael Levin

Frontiers in Systems Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Март 24, 2022

Synthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved designed material software. These advances are disrupting familiar concepts philosophy mind, require new ways thinking about comparing truly diverse intelligences, whose composition origin not like any available natural model species. In this Perspective, I introduce TAME-Technological Approach Mind Everywhere-a framework for understanding manipulating cognition unconventional substrates. TAME formalizes non-binary (continuous), empirically-based approach strongly agency. provides way think animal sentience an instance collective intelligence cell groups, arising from dynamics that manifest similar numerous other When applied regenerating/developmental systems, suggests perspective on morphogenesis example basal cognition. The deep symmetry between problem-solving anatomical, physiological, transcriptional, 3D (traditional behavioral) spaces drives specific hypotheses by which capacities can increase during evolution. An important medium exploited evolution joining active subunits into greater agents is developmental bioelectricity, implemented pre-neural use ion channels gap junctions scale up cell-level feedback loops anatomical homeostasis. This architecture multi-scale competency biological has implications plasticity bodies minds, greatly potentiating evolvability. Considering classical recent data perspectives computational science, evolutionary biology, cognition, reveals rich research program with many regenerative medicine, artificial intelligence.

Язык: Английский

Процитировано

127

Histone Methylation and Memory of Environmental Stress DOI Creative Commons
Paola Fabrizio, Steve Garvis, Francesca Palladino

и другие.

Cells, Год журнала: 2019, Номер 8(4), С. 339 - 339

Опубликована: Апрель 10, 2019

Cellular adaptation to environmental stress relies on a wide range of tightly controlled regulatory mechanisms, including transcription. Changes in chromatin structure and organization accompany the transcriptional response stress, some cases, can impart memory exposure subsequent generations through mechanisms epigenetic inheritance. In budding yeast Saccharomyces cerevisiae, histone post-translational modifications, particular methylation, have been shown confer conditions mitotic divisions. Recent evidence from Caenorhabditis elegans also implicates methylation transgenerational inheritance responses, suggesting more widely conserved role memory.

Язык: Английский

Процитировано

68

Unexplored power of CRISPR-Cas9 in neuroscience, a multi-OMICs review DOI
Mohammad Banazadeh, Ardavan Abiri,

Mohammad Mahdi Poortaheri

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 263, С. 130413 - 130413

Опубликована: Фев. 24, 2024

Язык: Английский

Процитировано

8

Exposure to sublethal doses of insecticide and their effects on insects at cellular and physiological levels DOI
Alexandre Bantz,

Jérémy Camon,

Josy‐Anne Froger

и другие.

Current Opinion in Insect Science, Год журнала: 2018, Номер 30, С. 73 - 78

Опубликована: Сен. 27, 2018

Язык: Английский

Процитировано

58

Stress sharing as cognitive glue for collective intelligences: A computational model of stress as a coordinator for morphogenesis DOI Creative Commons

Lakshwin Shreesha,

Michael Levin

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 731, С. 150396 - 150396

Опубликована: Июль 14, 2024

Individual cells have numerous competencies in physiological and metabolic spaces. However, multicellular collectives can reliably navigate anatomical morphospace towards much larger, reliable endpoints. Understanding the robustness control properties of this process is critical for evolutionary developmental biology, bioengineering, regenerative medicine. One mechanism that has been proposed enabling individual to coordinate toward specific morphological outcomes sharing stress (where a parameter reflects current amount error context homeostatic loop). Here, we construct analyze multiscale agent-based model morphogenesis which quantitatively examine impact on ability reach target morphology. We found improves morphogenetic efficiency collectives; populations with reached targets faster. Moreover, influenced future fate distant multi-cellular collective, enhancing cells' movement their radius influence, consistent hypothesis works increase cohesiveness collectives. During development, goal states could not be inferred from observation states, revealing limitations knowledge goals by an extern observer outside system itself. Taken together, our analyses support important role natural engineered systems seek robust large-scale behaviors emerge activity competent components.

Язык: Английский

Процитировано

6

Epigenetic response profiles into environmental epigenotoxicant screening and health risk assessment: A critical review DOI
Junjie Hu, Yingxin Yu

Chemosphere, Год журнала: 2019, Номер 226, С. 259 - 272

Опубликована: Март 18, 2019

Язык: Английский

Процитировано

40

Innate Immune Memory in Hematopoietic Stem/Progenitor Cells: Myeloid-Biased Differentiation and the Role of Interferon DOI Creative Commons
Lili Chen, Keiko Ozato

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Март 29, 2021

Innate immune memory was first described for monocytes and other myeloid cells. This is designated Immune Training , in which the host animals that had experienced pathogen infection earlier acquire improved resistance to a second infection. mediated by an epigenetic mechanism traced transcriptional conserved throughout evolution has been selected ability mount adaptive response shifting environments. Accumulating evidence shows not only peripheral cells but hematopoietic stem/progenitor (HSCs/HSPCs) can upon exposure. Systemic causes HSCs exit from quiescence facilitate myeloid-biased differentiation leads efficient defense. sequence of events common HSC generation, triggered different stimuli. Recent studies show pathogens stimuli such as metabolic stress generate HSCs. review summarizes recent publications relevant memory. We discuss current understanding initial sensors, soluble mediators/cytokines involved formation, including Type I II interferons along with future implications.

Язык: Английский

Процитировано

31

Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases DOI Creative Commons
Katarzyna Kaczmarek Michaels,

Salwa Mohd Mostafa,

Julia Ruiz Capella

и другие.

Nucleic Acids Research, Год журнала: 2020, Номер 48(10), С. 5407 - 5425

Опубликована: Апрель 18, 2020

Abstract Adjusting DNA structure via epigenetic modifications, and altering polyadenylation (pA) sites at which precursor mRNA is cleaved polyadenylated, allows cells to quickly respond environmental stress. Since occurs co-transcriptionally, specific patterns of nucleosome positioning chromatin modifications correlate with pA site usage, factors potentially affect alternative (APA). We report that the histone H3K4 methyltransferase Set1, H3K36 Set2, control choice in Saccharomyces cerevisiae, a powerful model for studying evolutionarily conserved eukaryotic processes. Deletion SET1 or SET2 causes an increase serine-2 phosphorylation within C-terminal domain RNA polymerase II (RNAP II) recruitment cleavage/polyadenylation complex, both could cause observed switch usage. Chemical inhibition TOR signaling, nutritional stress, results Set1- Set2-dependent APA. In addition, Set1 Set2 decrease efficiency using single sites, occupancy around sites. Overall, our study suggests methyltransferases regulate APA induced by RNAP Ser2, 3′ end processing machinery vicinity

Язык: Английский

Процитировано

27

Environmental Adaptation of Genetically Uniform Organisms with the Help of Epigenetic Mechanisms—An Insightful Perspective on Ecoepigenetics DOI Creative Commons
Günter Vogt

Epigenomes, Год журнала: 2022, Номер 7(1), С. 1 - 1

Опубликована: Дек. 26, 2022

Organisms adapt to different environments by selection of the most suitable phenotypes from standing genetic variation or phenotypic plasticity, ability single genotypes produce in environments. Because near identity, asexually reproducing populations are particularly for investigation potential and molecular underpinning latter alternative depth. Recent analyses on whole-genome scale differently adapted clonal animals plants demonstrated that epigenetic mechanisms such as DNA methylation, histone modifications non-coding RNAs among pathways supporting plasticity is used stably Case studies revealed habitat-specific fingerprints were maintained over subsequent years pointing at existence ecotypes. Environmentally induced epimutations corresponding gene expression changes provide an ideal means fast directional adaptation changing new conditions, because they can synchronously alter many population members. microorganisms inclusive human pathogens also exploit epigenetically mediated environmental adaptation, this phenomenon considered a universal biological principle. The production same sequence response cues provides mechanistic explanation “general-purpose genotype hypothesis” “genetic paradox invasions”.

Язык: Английский

Процитировано

16

Antioxidant system alterations and oxidative stress caused by polyfluoroalkyl substances (PFAS) in exposed biota: a review DOI
Lorena Oliveira Souza Soares, Gabriel de Farias Araújo,

Thais Braga Gomes

и другие.

The Science of The Total Environment, Год журнала: 2025, Номер 977, С. 179395 - 179395

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

0