Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

Frontiers in Systems Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: March 24, 2022

Synthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved designed material software. These advances are disrupting familiar concepts philosophy mind, require new ways thinking about comparing truly diverse intelligences, whose composition origin not like any available natural model species. In this Perspective, I introduce TAME-Technological Approach Mind Everywhere-a framework for understanding manipulating cognition unconventional substrates. TAME formalizes non-binary (continuous), empirically-based approach strongly agency. provides way think animal sentience an instance collective intelligence cell groups, arising from dynamics that manifest similar numerous other When applied regenerating/developmental systems, suggests perspective on morphogenesis example basal cognition. The deep symmetry between problem-solving anatomical, physiological, transcriptional, 3D (traditional behavioral) spaces drives specific hypotheses by which capacities can increase during evolution. An important medium exploited evolution joining active subunits into greater agents is developmental bioelectricity, implemented pre-neural use ion channels gap junctions scale up cell-level feedback loops anatomical homeostasis. This architecture multi-scale competency biological has implications plasticity bodies minds, greatly potentiating evolvability. Considering classical recent data perspectives computational science, evolutionary biology, cognition, reveals rich research program with many regenerative medicine, artificial intelligence.

Language: Английский

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Histone Methylation and Memory of Environmental Stress

Cells, Journal Year: 2019, Volume and Issue: 8(4), P. 339 - 339

Published: April 10, 2019

Cellular adaptation to environmental stress relies on a wide range of tightly controlled regulatory mechanisms, including transcription. Changes in chromatin structure and organization accompany the transcriptional response stress, some cases, can impart memory exposure subsequent generations through mechanisms epigenetic inheritance. In budding yeast Saccharomyces cerevisiae, histone post-translational modifications, particular methylation, have been shown confer conditions mitotic divisions. Recent evidence from Caenorhabditis elegans also implicates methylation transgenerational inheritance responses, suggesting more widely conserved role memory.

Language: Английский

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Unexplored power of CRISPR-Cas9 in neuroscience, a multi-OMICs review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130413 - 130413

Published: Feb. 24, 2024

Language: Английский

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Exposure to sublethal doses of insecticide and their effects on insects at cellular and physiological levels

Current Opinion in Insect Science, Journal Year: 2018, Volume and Issue: 30, P. 73 - 78

Published: Sept. 27, 2018

Language: Английский

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Stress sharing as cognitive glue for collective intelligences: A computational model of stress as a coordinator for morphogenesis

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 731, P. 150396 - 150396

Published: July 14, 2024

Individual cells have numerous competencies in physiological and metabolic spaces. However, multicellular collectives can reliably navigate anatomical morphospace towards much larger, reliable endpoints. Understanding the robustness control properties of this process is critical for evolutionary developmental biology, bioengineering, regenerative medicine. One mechanism that has been proposed enabling individual to coordinate toward specific morphological outcomes sharing stress (where a parameter reflects current amount error context homeostatic loop). Here, we construct analyze multiscale agent-based model morphogenesis which quantitatively examine impact on ability reach target morphology. We found improves morphogenetic efficiency collectives; populations with reached targets faster. Moreover, influenced future fate distant multi-cellular collective, enhancing cells' movement their radius influence, consistent hypothesis works increase cohesiveness collectives. During development, goal states could not be inferred from observation states, revealing limitations knowledge goals by an extern observer outside system itself. Taken together, our analyses support important role natural engineered systems seek robust large-scale behaviors emerge activity competent components.

Language: Английский

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Epigenetic response profiles into environmental epigenotoxicant screening and health risk assessment: A critical review

Chemosphere, Journal Year: 2019, Volume and Issue: 226, P. 259 - 272

Published: March 18, 2019

Language: Английский

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Innate Immune Memory in Hematopoietic Stem/Progenitor Cells: Myeloid-Biased Differentiation and the Role of Interferon

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: March 29, 2021

Innate immune memory was first described for monocytes and other myeloid cells. This is designated Immune Training , in which the host animals that had experienced pathogen infection earlier acquire improved resistance to a second infection. mediated by an epigenetic mechanism traced transcriptional conserved throughout evolution has been selected ability mount adaptive response shifting environments. Accumulating evidence shows not only peripheral cells but hematopoietic stem/progenitor (HSCs/HSPCs) can upon exposure. Systemic causes HSCs exit from quiescence facilitate myeloid-biased differentiation leads efficient defense. sequence of events common HSC generation, triggered different stimuli. Recent studies show pathogens stimuli such as metabolic stress generate HSCs. review summarizes recent publications relevant memory. We discuss current understanding initial sensors, soluble mediators/cytokines involved formation, including Type I II interferons along with future implications.

Language: Английский

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Antioxidant system alterations and oxidative stress caused by polyfluoroalkyl substances (PFAS) in exposed biota: a review

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 977, P. 179395 - 179395

Published: April 16, 2025

Language: Английский

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Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases

Nucleic Acids Research, Journal Year: 2020, Volume and Issue: 48(10), P. 5407 - 5425

Published: April 18, 2020

Abstract Adjusting DNA structure via epigenetic modifications, and altering polyadenylation (pA) sites at which precursor mRNA is cleaved polyadenylated, allows cells to quickly respond environmental stress. Since occurs co-transcriptionally, specific patterns of nucleosome positioning chromatin modifications correlate with pA site usage, factors potentially affect alternative (APA). We report that the histone H3K4 methyltransferase Set1, H3K36 Set2, control choice in Saccharomyces cerevisiae, a powerful model for studying evolutionarily conserved eukaryotic processes. Deletion SET1 or SET2 causes an increase serine-2 phosphorylation within C-terminal domain RNA polymerase II (RNAP II) recruitment cleavage/polyadenylation complex, both could cause observed switch usage. Chemical inhibition TOR signaling, nutritional stress, results Set1- Set2-dependent APA. In addition, Set1 Set2 decrease efficiency using single sites, occupancy around sites. Overall, our study suggests methyltransferases regulate APA induced by RNAP Ser2, 3′ end processing machinery vicinity

Language: Английский

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Environmental Adaptation of Genetically Uniform Organisms with the Help of Epigenetic Mechanisms—An Insightful Perspective on Ecoepigenetics

Epigenomes, Journal Year: 2022, Volume and Issue: 7(1), P. 1 - 1

Published: Dec. 26, 2022

Organisms adapt to different environments by selection of the most suitable phenotypes from standing genetic variation or phenotypic plasticity, ability single genotypes produce in environments. Because near identity, asexually reproducing populations are particularly for investigation potential and molecular underpinning latter alternative depth. Recent analyses on whole-genome scale differently adapted clonal animals plants demonstrated that epigenetic mechanisms such as DNA methylation, histone modifications non-coding RNAs among pathways supporting plasticity is used stably Case studies revealed habitat-specific fingerprints were maintained over subsequent years pointing at existence ecotypes. Environmentally induced epimutations corresponding gene expression changes provide an ideal means fast directional adaptation changing new conditions, because they can synchronously alter many population members. microorganisms inclusive human pathogens also exploit epigenetically mediated environmental adaptation, this phenomenon considered a universal biological principle. The production same sequence response cues provides mechanistic explanation “general-purpose genotype hypothesis” “genetic paradox invasions”.

Language: Английский

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