The Science of The Total Environment, Год журнала: 2022, Номер 833, С. 155127 - 155127
Опубликована: Апрель 11, 2022
Язык: Английский
Annals of Global Health, Год журнала: 2020, Номер 86(1), С. 151 - 151
Опубликована: Дек. 3, 2020
Background: Pollution – unwanted waste released to air, water, and land by human activity is the largest environmental cause of disease in world today. It responsible for an estimated nine million premature deaths per year, enormous economic losses, erosion capital, degradation ecosystems. Ocean pollution important, but insufficiently recognized inadequately controlled component global pollution. poses serious threats health well-being. The nature magnitude these impacts are only beginning be understood. Goals: (1) Broadly examine known potential ocean on health. (2) Inform policy makers, government leaders, international organizations, civil society, public threats. (3) Propose priorities interventions control prevent seas safeguard Methods: Topic-focused reviews that effects health, identify gaps knowledge, project future trends, offer evidence-based guidance effective intervention. Environmental Findings: oceans widespread, worsening, most countries poorly controlled. a complex mixture toxic metals, plastics, manufactured chemicals, petroleum, urban industrial wastes, pesticides, fertilizers, pharmaceutical agricultural runoff, sewage. More than 80% arises from land-based sources. reaches through rivers, atmospheric deposition direct discharges. often heaviest near coasts highly concentrated along low- middle-income countries. Plastic rapidly increasing visible pollution, 10 metric tons plastic enter each year. Mercury metal pollutant greatest concern oceans; it two main sources coal combustion small-scale gold mining. Global spread industrialized agriculture with use chemical fertilizer leads extension Harmful Algal Blooms (HABs) previously unaffected regions. Chemical pollutants ubiquitous contaminate marine organisms high Arctic abyssal depths. Ecosystem has multiple negative ecosystems, exacerbated climate change. Petroleum-based reduce photosynthesis microorganisms generate oxygen. Increasing absorption carbon dioxide into causes acidification, which destroys coral reefs, impairs shellfish development, dissolves calcium-containing at base food web, increases toxicity some pollutants. threatens mammals, fish, seabirds accumulates large mid-ocean gyres. breaks down microplastic nanoplastic particles containing chemicals can tissues organisms, including species consumed humans. Industrial releases, sewage increase frequency severity HABs, bacterial anti-microbial resistance. sea surface warming triggering poleward migration dangerous pathogens such as Vibrio species. discharges, contribute declines fish stocks. Human Health Methylmercury PCBs whose best Exposures infants in utero maternal consumption contaminated seafood damage developing brains, IQ children's risks autism, ADHD learning disorders. Adult exposures methylmercury cardiovascular dementia. Manufactured phthalates, bisphenol A, flame retardants, perfluorinated many them disrupt endocrine signaling, male fertility, nervous system, risk cancer. HABs produce potent toxins accumulate shellfish. When ingested, severe neurological impairment rapid death. HAB also become airborne respiratory disease. Pathogenic bacteria gastrointestinal diseases deep wound infections. With change infections, cholera, will extend new areas. All fall disproportionately vulnerable populations South injustice planetary scale. Conclusions: problem. crosses national boundaries. consequence reckless, shortsighted, unsustainable exploitation earth's resources. endangers impedes production Its great growing, still incompletely costs counted. prevented. Like all forms deploying data-driven strategies based law, policy, technology, enforcement target priority Many have used tools air water now applying Successes achieved date demonstrate broader feasible. Heavily polluted harbors been cleaned, estuaries rejuvenated, reefs restored. Prevention creates benefits. boosts economies, tourism, helps restore fisheries, improves advances Sustainable Development Goals (SDG). These benefits last centuries. Recommendations: World leaders who recognize gravity acknowledge its growing dangers, engage society public, take bold, action stop source critical preventing safeguarding key. Eliminating banning uses mercury Bans single-use better management persistent organic (POPs) reduced DDT. Control treatment sewage, applications fertilizers mitigated coastal reducing HABs. National, regional programs adequately funded backed strong shown effective. Robust monitoring essential track progress. Further hold promise include wide-scale transition renewable fuels; circular economy little focuses equity rather endless growth; embracing principles green chemistry; building scientific capacity Designation Marine Protected Areas (MPAs) protect stocks, enhance Creation MPAs important manifestation commitment protecting seas.
Язык: Английский
Процитировано
571
Reviews in Endocrine and Metabolic Disorders, Год журнала: 2019, Номер 21(1), С. 127 - 147
Опубликована: Дек. 3, 2019
Язык: Английский
Процитировано
536
Toxics, Год журнала: 2022, Номер 10(7), С. 365 - 365
Опубликована: Июль 1, 2022
In the last decade or so, polychlorinated biphenyls (PCBs) garnered renewed attention in scientific community due to new evidence pointing at their continued presence environment and workplaces potential human risks related presence. PCBs move from humans through different routes; dominant pathway is ingestion of contaminated foods (fish, seafood dairy products), followed by inhalation (both indoor outdoor air), and, a lesser extent, dust dermal contact. Numerous studies reported environmental occupational exposure these pollutants, deriving building materials (flame-retardants, plasticizers, paints, caulking compounds, sealants, fluorescent light ballasts, etc.) electrical equipment. The highest contaminations were detected e-waste recycling sites, suggesting need for implementation remediation strategies such polluted areas safeguard health workers local populations. Furthermore, significant correlation between PCB increased blood concentrations was observed people working PCB-contaminated workplaces. Several epidemiological suggest that high associated with outcomes, as neuropsychological neurobehavioral deficits, dementia, immune system dysfunctions, cardiovascular diseases cancer. addition, recent indicate bioaccumulation can reduce fertility, harmful effects on reproductive be passed offspring. near future, further are needed assess real low prolonged specific environments.
Язык: Английский
Процитировано
151
Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 78(3), С. 909 - 922
Опубликована: Сен. 23, 2020
Язык: Английский
Процитировано
144
The Science of The Total Environment, Год журнала: 2021, Номер 805, С. 150270 - 150270
Опубликована: Сен. 11, 2021
Язык: Английский
Процитировано
123
Ecotoxicology and Environmental Safety, Год журнала: 2022, Номер 243, С. 113972 - 113972
Опубликована: Авг. 24, 2022
Parkinson's disease (PD) is a neurodegenerative disorder which mainly targets motor symptoms such as tremor, rigidity, bradykinesia and postural instability. The physiological changes occur due to dopamine depletion in basal ganglia region of the brain. PD aetiology not yet elucidated clearly but genetic environmental factors play prominent role occurrence. Despite various factors, pesticides exposure has been convicted major candidate pathogenesis. Among 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) widely investigated following with paraquat (PQ), maneb (MB), organochlorines (OC) rotenone. Effect these suggested be involved oxidative stress, alterations transporters, mitochondrial dysfunction, α-synuclein (αSyn) fibrillation, neuroinflammation PD. present review discusses influence neurodegeneration its related epidemiological studies conducted Furthermore, we have deliberated common associated probable mechanism them behind Hence, conclude that pathogenesis advance research needed investigate mechanistic aspects
Язык: Английский
Процитировано
77
International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(3), С. 1013 - 1013
Опубликована: Фев. 4, 2020
Despite being banned from production for decades, polychlorinated biphenyls (PCBs) continue to pose a significant risk human health. This is due not only the continued release of legacy PCBs PCB-containing equipment and materials manufactured prior ban on PCB production, but also inadvertent as byproducts contemporary pigment dye production. Evidence animal studies clearly identifies developmental neurotoxicity primary endpoint concern associated with exposures. However, relative role(s) specific congeners in mediating adverse effects developing nervous system, mechanism(s) by which disrupt typical neurodevelopment remain outstanding questions. New questions are emerging regarding potential lower chlorinated that were present commercial mixtures, constitute proportion Here, we review behavioral mechanistic data obtained experimental models well recent epidemiological suggest non-dioxin-like (NDL) primarily responsible PCBs. We discuss demonstrating non-legacy, cause neurodevelopmental outcomes. Molecular targets, relevance interactions these targets disorders, critical gaps addressed well.
Язык: Английский
Процитировано
102
Chemosphere, Год журнала: 2023, Номер 332, С. 138877 - 138877
Опубликована: Май 8, 2023
Язык: Английский
Процитировано
25
Maturitas, Год журнала: 2024, Номер 185, С. 107981 - 107981
Опубликована: Март 30, 2024
Язык: Английский
Процитировано
17
The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171291 - 171291
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
15